Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity

Zhao, Gui-Jun; Li, Xia; Chen, Wansheng; Xi, Zhong-Xin; Sun, Lianna

doi:10.1016/j.fitote.2012.09.007

Cited by 48 publications

(28 citation statements)

References 22 publications

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“…Daun T. diversifolia mengandung senyawa alkaloid, terpenoid, flavonoid, saponin, tanin, polifenol, dan golongan seskuiterpen (Jamal & Agusta, 1999). T. diversifolia merupakan tanaman yang digunakan masyarakat China untuk antidiabetes (Zhao et al, 2012). Dosis penggunaan daun T. diversifolia oleh masyarakat adalah 5 lembar setara 2 g.…”

Section: Pendahuluanunclassified

“…T. diversifolia juga memiliki komponen yang disebut seskuiterpen yang berfungsi mengurangi ketidaksensitifan terhadap insulin (Miura et al, 2002). Seskuiterpen secara signifikan mampu meningkatkan metabolisme glukosa tanpa efek toksik pada adiposit (Zhao et al, 2012). Seskuiterpen dapat menghambat faktor inflamasi pada sel mesangial ginjal manusia dalam kondisi hiperglikemik (Wang et al, 2010).…”

Section: Pengaruh Ekstrak Daun Kembang Bulan Terhadap Penurunan Kadarunclassified

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Efek Ekstrak Daun Kembang Bulan (Tithonia diversifolia) terhadap Kadar Glukosa Darah Tikus Wistar (Rattus norvegicus) yang Diinduksi Alloxan

et al. 2017

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Diabetes Mellitus is a metabolic disease marked increase in blood sugar or hyperglycemia. Hyperglycemia occurs due to abnormalities in insulin secretion or insulin action. Alloxan induced diabetes with damaging cells of the pancreas and initiate the occurrence of hyperglycemia. One of the plants that have medicinal potential to decreasing of blood glucose its a Tithonia diversifolia leaves, which contains flavonoids and sesquiterpenes. The purpose of this research are (1) Analyzing the effect of Tithonia diversifolia leaves extract to decreasing blood glucose Wistar rats induced with alloxan; (2) Determining the effective dose of Tithonia diversifolia leaves extract in decreasing blood glucose Wistar rats. This is a True Experimental-Post Test Only Control Group Design referenced to Sambrook & Russel. The samples used were twenty-five Wistar rats divided into 5 groups and 5 repetitions ie P1 (control), P2 (alloxan only), P3 (alloxan and dose of 1.28 ml/200g BW), P4 (alloxan and dose of 2,57 ml/200g BB) and P5 (alloxan and dose of 5.14 ml/200g BB). The data analysis technique used One-way ANOVA followed by Duncan test.The research showed that there was an effect of Tithonia diversifolia leaves extract to decrease blood glucose levels of Wistar rats. It is concluded that Tithonia diversifolia leaves extract at dose 5,14 ml/200g BB has antidiabetic effect. Key Words : diabetes mellitus, tithonia, alloxan, flavonoid AbstrakDiabetes Mellitus merupakan penyakit metabolik yang ditandai kenaikan kadar gula darah atau hiperglikemia yang terjadi karena kelainan sekresi insulin atau kerja insulin. Alloxan menginduksi diabetes dengan merusak sel pankreas dan mengawali terjadinya hiperglikemia. Salah satu tumbuhan yang memiliki potensi penurunan glukosa darah adalah daun Tithonia diversifolia karena mengandung senyawa flavonoid dan seskuiterpen. Tujuan penelitian ini adalah (1) menganalisis efek ekstrak daun kembang bulan terhadap penurunan kadar glukosa darah tikus Wistar; dan (2) menentukan pemberian ekstrak daun kembang bulan yang memiliki pengaruh efektif dalam penurunan kadar glukosa darah tikus Wistar. Rancangan yang digunakan adalah True Experimental-Post Test Only Control Group Design mengacu pada Sambrook & Russel. Sampel yang digunakan adalah tikus Wistar sebanyak 25 ekor yang terbagi dalam 5 kelompok perlakuan dan 5 kali pengulangan yaitu P1 (kontrol), P2 (hanya alloxan), P3 (alloxan dan dosis 1,28 ml/200g BB), P4 (aloxan dan dosis 2,57 ml/200g BB), dan P5 (alloxan dan dosis 5,14 ml/200g BB). Analisis data menggunakan One-way ANOVA yang dilanjutkan uji Duncan. Hasil penelitian menunjukkan bahwa ada efek ekstrak daun kembang bulan terhadap penurunan kadar glukosa darah tikus Wistar. Daun kembang bulan memiliki efek antidiabetes atau berperan sebagai antihiperglikemik pada pemberian dosis sebesar 5,14 ml/200g BB.

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Section: Pendahuluanunclassified

Section: Pengaruh Ekstrak Daun Kembang Bulan Terhadap Penurunan Kadarunclassified

Efek Ekstrak Daun Kembang Bulan (Tithonia diversifolia) terhadap Kadar Glukosa Darah Tikus Wistar (Rattus norvegicus) yang Diinduksi Alloxan

et al. 2017

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“…Furthermore, through in vitro studies using HepG2 cells, it is known that the compounds of the sesquiterpene lactone, thyrotundin and tagitinin A, can increase the activity of peroxisome proliferator-activated receptors (PPARs) γ which is to increase insulin sensitivity (Lin, 2012). Sesquiterpene lactones from Tithonia diversifolia plant also proved to increase glucose uptake in 3T3-L1 adipocyte cell cultures with glucose exposure (Zhao, Li, Chen, Xi, & Sun, 2012). The glucose that moves in the cell prevents lipolysis on adipose tissue, so there is no breaking of the fatty period, and the weight of the diabetic rat can gradually improve (Krauss, 2004).…”

Section: Resultsmentioning

confidence: 99%

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats

Fauziyah¹,

Sunarti²,

Hanoum³

et al. 2018

Molekul

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Diabetes mellitus is a state of chronic hyperglycemia which causes various complications. Traditionally, The Tithonia diversifolia (Hemsley) A Gray leaf has long been used for the treatment of diabetes. The aim of this study is to investigate the effect of the T. diversifolia leaf on blood glucose, polyphagia, and weight loss in a diabetic rat model. Rats were made diabetic with intraperitonial injection of Nicotinamide and Streptozotocin and divided into 5 groups. Group 1 were healthy rats, group 2 were diabetic rats, while groups 3, 4, and 5 were diabetic rats treated with 25, 50, and 100 mg/kg body weight of 70% ethanol extract of Tithonia diversifolia leaf respectively for 28 days. Blood was taken after treatment for measuring glucose. The ethanol extract of T. diversifolia leaf decreased blood glucose in diabetic rats (P<0.05). The ethanol extract of T. diversifolia leaf significantly suppresses polyphagia and improves diabetic rat weight (P <0.05). In conclusion, Tithonia diversifolia ethanolic extract has anti-hyperglycemic effect and ameliorated the effect of diabetes mellitus symptoms, namely polyphagia and weight loss.

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“…T. diversifolia contain many compounds. [77] found about 16 compounds while [78] review about 150 compounds of Tithonia and 150 compounds of Tithonia diversifolia. Some of them are shown in Figure 4.…”

Section: Tithonia Diversifoliamentioning

confidence: 99%

The Potential of Using Indigenous Pesticidal Plants for Insect Pest Control to Small Scale Farmers in Africa

Mkindi¹,

Mtei²,

Njau³

et al. 2015

AJPS

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Pesticidal plants are scientifically proven for their effectiveness in controlling insect pests. Their activity is enhanced by active compounds contained, which are known for their repellant and antifeedant potentials to the insects. Use of pesticidal plants by local small scale farmers has been a point of concern following information that majority of farmers do not widely use pesticidal plants despite of an indigenous knowledge that they possess. Improvement of the technologies used by local farmers in previous times, that are easy and effective need to help farmers abstain from the use of synthetic pesticides that are detrimental to the environment and to their own health. This paper reviews the potentiality of pesticidal plants to small holder farmers. It also gives the status of pesticidal plants use, their possible effectiveness against insect pests, persistence as well as the knowledge that indigenous people possess in their use. Again, the paper suggests the need for more instrumental research on practical improvement of indigenous knowledge on the use of pesticidal plants with scientific evidences.

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Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity

Cited by 48 publications

References 22 publications

Efek Ekstrak Daun Kembang Bulan (Tithonia diversifolia) terhadap Kadar Glukosa Darah Tikus Wistar (Rattus norvegicus) yang Diinduksi Alloxan

Efek Ekstrak Daun Kembang Bulan (Tithonia diversifolia) terhadap Kadar Glukosa Darah Tikus Wistar (Rattus norvegicus) yang Diinduksi Alloxan

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats

The Potential of Using Indigenous Pesticidal Plants for Insect Pest Control to Small Scale Farmers in Africa

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