Three new mixed‐ligand copper(II) complexes containing glycyl‐l‐valine and N,N‐aromatic heterocyclic compounds: Synthesis, characterization, DNA interaction, cytotoxicity and antimicrobial activity

Abstract

Three novel copper(II) complexes, [Cu(Gly‐l‐Val)(HPBM)(H2O)]·ClO4·H2O (1), [Cu(Gly‐l‐Val)(TBZ)(H2O)]·ClO4 (2) and [Cu(Gly‐l‐Val)(PBO)(H2O)]·ClO4 (3) (Gly‐l‐Val = glycyl‐l‐valine anion, HPBM = 5‐methyl‐2‐(2′‐pyridyl)benzimidazole, TBZ = 2‐(4′‐thiazolyl)benzimidazole, PBO = 2‐(2′‐pyridyl)benzoxazole), have been prepared and characterized with elemental analyses, conductivity measurements as well as various spectroscopic techniques. The interactions of these copper complexes with calf thymus DNA were explored using UV–visible, fluorescence, circular dichroism, thermal denaturation, viscosity and docking analyses methods. The experimental results showed that all three complexes could bind to DNA via an intercalative mode. Moreover, the cytotoxic effects were evaluated using the MTT method, and the antimicrobial activity of these complexes was tested against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results showed that the activities are consistent with their DNA binding abilities, following the order of 1 > 2 > 3.

Synthesis, structural studies, interaction with DNA/HSA and antitumor evaluation of new Cu(ii) complexes containing 2-(1H-imidazol-2-yl)pyridine and amino acids

“…10–12 In addition, l -amino acids are important biological metabolites with high biocompatibility, and they can greatly improve the hydrophilicity of metal complexes after coordination with metal ions, which is conducive to the dissolution and diffusion of the complexes in organisms. 13,14 It is beneficial to further regulate the lipophilicity, bioactivity and bioavailability of the complexes. 15…”

Sparfloxacin – Cu(ii) – aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

“…Molecular docking was used to visualize the interaction between the complexes and DNA, in which the double-stranded DNA sequences d(5′-G-dIU-TGCAAC-3′) (PDB ID: ) were selected. 37,38 As shown in Fig. 5, the GC/GC base cavity positions were mainly occupied by the complexes.…”

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

“…The authors mention that the results obtained were consistent with their DNA binding abilities. A change in the properties of the substituent and in the binding sites of the ligand can originate certain modifications in the spatial configuration and density distribution of the electron cloud of the complexes, causing differences in the DNA-binding properties or in the bioactivity [87].…”