Synthesis, structural studies, interaction with DNA/HSA and antitumor evaluation of new Cu(ii) complexes containing 2-(1H-imidazol-2-yl)pyridine and amino acids

Abstract

Copper complexes are considered as potential candidates for anticancer therapy and medical applications. In this paper, three new Cu(II) complexes, [Cu(IPY)2](ClO4)2·H2O (CuI1), [Cu(IPY)(L-Phe)H2O]ClO4·0.5H2O (CuI2) and [Cu(IPY)(L-Val)H2O]ClO4 (CuI3) (where IPY =...

Membrane Vesicles of Toxigenic Clostridioides difficile Affect the Metabolism of Liver HepG2 Cells

“…Although we observed a decrease in MMP after incubation with toxigenic and non-toxigenic C. difficile -derived MVs, only those MVs from toxigenic C. difficile resulted in increased cellular stress through intracellular ROS generation. This mechanism of action, the elevation of intracellular ROS and loss of MMP, has already been described for other molecules [ 52 ]. The decrease found in MMP may imply that the process that damages the mitochondria exceeds the capacity to fix/remove the damaged ones [ 53 ] and could trigger a mitochondrial degradation [ 54 ].…”

Noncovalent interactions of antitumor cycloplatinated complexes containing trifluoroacetate ligands as the leaving group with bovine serum albumin. Implications for drug design

“…Even so, at fixed Δ λ = 15 nm, while the quenching was observed by increasing concentrations of Pt compounds, the maximum emission wavelength remained almost unchanged. These observations signify that the microenvironment in near Tyr residues did not show main change 57,69 and only tryptophan residues are likely involved in the binding process.…”

“…Even so, at fixed Dl = 15 nm, while the quenching was observed by increasing concentrations of Pt compounds, the maximum emission wavelength remained almost unchanged. These observations signify that the microenvironment in near Tyr residues did not show main change 57,69 and only tryptophan residues are likely involved in the binding process. This is in contrast to the data obtained for cisplatin, where during the interaction with SA proteins, the maximum emission wavelength red-shifted and cisplatin interacted with SA-proteins mostly by covalent interactions.…”

Facile synthesis of novel NNO-tethered copper(ii) complexes: characterization details, theoretical studies, promising enzyme-like activities, and biomolecular interactions

“…Copper-based anticancer drugs provide a broad therapeutic window against a wide range of cancer cell lines, with reduced off-target toxicity and fewer side effects, allowing them to circumvent the difficulties associated with platinum-based treatment options. 54–56 Therefore, systematic studies of circulating tumor (ct)DNA interactions with novel copper( ii ) complexes are crucial.…”