Three new megastigmanes from the leaves of Annona muricata

Abstract

Three new megastigmanes (1-3), named annoionols A and B (1, 2) and annoionoside (3), were isolated from the leaves of Annona muricata L. (Annonaceae) together with 14 known compounds (4-17). Among the known compounds, annoionol C (4) was isolated from a natural source for the first time. The structures of all compounds were elucidated by spectroscopic and chemical analyses.

Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds

“…1A). Indeed, these two compounds were already identified in this species (Matsushige et al, 2012b;Nawwar et al, 2012). Fig.…”

Review of Phytochemical and Medical Applications of Annona Muricata Fruits

“…These compounds are called Annonaceous acetogenins (AGEs), which were shown to induce cell cytotoxicity by inhibiting the mitochondrial complex I [40]. Other studies have also suggested the presence of compounds such as megastigmanes [41], cyclopeptides and essential oils [42,43], as well as essential minerals, such as K, Ca, Na, Cu, Fe, and Mg [44].…”

Annona muricata Extract Reduces Inflammation via Inactivation of NALP3 Inflammasome

“…Annona species, especially Annona muricata (AM), have been wellknown for their richness in Annonaceous Acetogenin compounds (AGEs) 4 . Phytochemical estimation of AM leaves revealed the existence of alkaloids 5,6 , flavonol triglycosides 7 , megastigmanes 8 , cyclopeptides 9 and phenolic compounds 10 . In addition, AM leaves contain numerous minerals such as K, Na, Ca, Mg and Cu and Mg that are essential for human health.…”