Three-layer structure graphene/mesoporous silica composites incorporated with C8-modified interior pore-walls for residue analysis of glucocorticoids in milk by liquid chromatography–tandem mass spectrometry

A C₈-Modified Graphene@mSiO₂ Composites Based Method for Quantification of Gallic Acid in Rat Plasma after Oral Administration of Changtai Granule and Its Application to Pharmacokinetics

“…Validation of C 8 -Modified Graphene@mSiO 2 Composites By using the facile one-pot-sol-gel approach, the C 8 -modified graphene@mSiO 2 composites were synthesized through the simultaneous condensation of TEOS and C 8 TES in the presence of graphene as the seeds and CTAB as the template. According to our previous work, [26][27][28] the mesopore channels in the shell are perpendicular to the surface of the as-prepared composites, and the pore size is about 3.0 nm with narrow pore size distribution. Theoretically, these mesopores on the surface of the composites can prevent irreversible adsorption of the proteins from the sample matrix due to size exclusion effect.…”

“…We hypothesized that the combination of graphene nanosheets and mesoporous silica would generate a hybrid nanomaterial that could improve the interfacial properties of graphene and integrate the advantages of both components. 26,27) Recently, our group has done a good deal of work to synthesize magnetic mesoporous silica microspheres for sample preparation. [21][22][23][24] Liu's team has reported the application of C 8 -modified composites in the extraction of glucocorticoid drugs from milk, 28) which shows the possibility of drug extraction from plasma samples by such composites.…”

Determination of Tetracyclines in Milk by Graphene-Based Solid-Phase Extraction and High-Performance Liquid Chromatography

“…In previous reports, graphene, amine modified graphene, and carboxyl graphene have been used to purify various analytes (Chen et al 2010;Liu et al 2011aLiu et al , 2011bWu et al 2011;Zhang, Low, and Lee 2012;Bai et al 2013;Chen et al 2013;Guan et al 2013;Tabani et al 2013;Shi et al 2014;Yan et al 2014;Liu et al 2015). In the present study, these materials were used to prepare SPE columns, and the performance for tetracyclines was compared.…”

“…In recent years, graphene has been used to develop SPE procedures for pesticides (Tabani et al 2013;Shi et al 2014), organic contaminants (Chen et al 2013;Liu et al 2011b;Zhang, Low, and Lee 2012), metal ions , and veterinary drugs (Yan et al 2014;Liu et al 2015). Other graphene-based methods have also been developed, such as dispersive solid phase extraction (Wu et al 2011;Bai et al 2013;Guan et al 2013), solid phase microextraction (Chen et al 2010), and matrix solid phase dispersion (Liu et al 2011a).…”

Microwave-assisted enzymatic hydrolysis followed by extraction with restricted access nanocomposites for rapid analysis of glucocorticoids residues in liver tissue

“…RAM-dSPE employs porous silica materials for the separation of low-molecular-weight analytes from matrix components by a combination of size exclusion and conventional adsorption chromatography. In our previous works [22], various graphene-based mesoporous silica materials were synthesized as the RAM-dSPE adsorbents. In this work, sandwich-structured graphene/mesoporous silica composites with C8-modified porewalls (denoted as C) were successfully prepared via a simple route utilized to extract glucocorticoids released from liver tissues.…”