Three-Dimensional Visualization in Medicine and Biology

Robb, Richard A.

doi:10.1016/b978-012077790-7/50049-7

Cited by 34 publications

(21 citation statements)

References 45 publications

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“…The main focus has primarily been to gain anatomical, physiological, and functional information in order to understand their relationship to each other [34] and to detect and treat disease. The collected information is typically retrievable in a database [35] or atlas [23,36].…”

Section: Data Processingmentioning

confidence: 99%

Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry

Crecelius

Cornett

Caprioli

et al. 2005

J. Am. Soc. Mass Spectrom.

151

149

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We have developed a method to visualize matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI IMS) data aligned with optically determinable tissue structures in three dimensions. Details of the methodology are exemplified using the 3-D reconstruction of myelin basic protein (MBP) in the corpus callosum of a mouse brain. In this procedure, optical images obtained from serial coronal sections are first aligned to each other to reconstruct a surface of the corpus callosum from segmented contours of the aligned images. The MALDI IMS data are then coregistered to the optical images and superimposed into the surface to create the final 3-D visualization. Correlating proteomic data with anatomical structures provides a more comprehensive understanding of healthy and pathological brain functions, and holds promise to be utilized in more complex anatomical arrangements. (J Am Soc Mass Spectrom 2005, 16, 1093-1099

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Section: Data Processingmentioning

confidence: 99%

Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry

Crecelius

Cornett

Caprioli

et al. 2005

J. Am. Soc. Mass Spectrom.

151

149

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“…Each colored region in the multispectral image corresponds to a uniquely segmented anatomical structure. Robb, 2000b) is more compute intensive than parallel rendering. It is especially key for applications such as virtual endoscopy, but is now commonly used for most volume rendering because of the increased performance of inexpensive computers.…”

Section: Algorithm Development and Validation Using The Vhdmentioning

confidence: 99%

Biomedical image visualization research using the Visible Human Datasets

Robb

Hanson

2006

Clinical Anatomy

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The practice of medicine and conduct of research in major segments of the biologic sciences have always relied on visualizations to study the relationship of anatomic structure to biologic function. Traditionally, these visualizations have either been direct, via vivisection and postmortem examination, or have required extensive mental reconstruction. The revolutionary capabilities of 3-D and 4-D medical imaging modalities, together with computer reconstruction and rendering of multidimensional medical and histological volume image data, obviate the need for physical dissection or abstract assembly. The availability of the Visible Human Datasets from the National Library of Medicine, coupled with the development of advanced computer algorithms to accurately and rapidly process, segment, register, measure, and display high resolution 3-D images, has provided a rich opportunity to help advance these important new imaging, visualization, and analysis methodologies from scientific theory to clinical practice.

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“…Se han aplicado a múltiples campos en Medicina y Biología [31]. Entre ellas distinguimos principalmente dos tipos:…”

Section: Técnicas 3dunclassified

Virtopsia: Aplicaciones de un nuevo método de inspección corporal no invasiva en ciencias forenses

Aso¹,

Martínez-Quiñones²,

Aso-Vizán

et al. 2005

Cuad. med. forense

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RESUMENLos modernos métodos de imagen, como la CT y la RNM proporcionan datos reales y tridimensionales de la superficie y las estructuras internas corporales. Esta información se almacena en ficheros DICOM (un protocolo estándar en adquisición de imagen radiológica). Sobre esos ficheros pueden realizarse muchos procedimientos de análisis de imagen, tales como visualización interactiva, morfometría, reconstrucciones tridimensionales, etc. Estas tareas son realizadas de una manera no invasiva y no destructiva, pudiéndose almacenar los resultados para documentación del caso. El presente trabajo describe las bases de los procedimientos de análisis de imagen sobre ficheros DICOM dirigidos a propósitos forenses (la llamada "virtopsia"), enfatizando la utilidad del método en Patología, Traumatología Forense y otros campos.La "virtopsia" debe ser considerada no sólo como un procedimientos post-mortem (complementando pero no sustituyendo a la autopsia tradicional), sino como un modo de examinar partes corporales de una manera interactiva, sea en el fallecido o en el sujeto vivo. Ello amplia su utilidad y hace apropiado el procedimiento siempre que se requiera un examen anatómico forense reproducible, preciso, interactivo y en tiempo real.Palabras clave: Análisis de imagen, Proceso de imagen, ficheros DICOM, Radiología digital, Autopsia, Virtopsia, Radiología cadavérica, Radiología asistida por ordenador. Cuad Med Forense 2005; 11(40):95-106 ABSTRACTModern imaging methods, such as radiological CT/MRI scanning provides real, full 3D data of the body surface and internal structures. This information is stored in DICOM files (a standard protocol in radiology image acquisition). Many image-analysis procedures, such as interactive visualization, morphometry, densitometry, three dimensional reconstruction, etc., can be carried-out on these files. These tasks are performed in a non-invasive and non-destructive manner, and the results can be stored in order to document the case.The present paper describes the basis of imageanalysis procedures on DICOM files directed to forensic purposes (socalled "virtopsy"), emphasizing the utility of the method in Pathology, Forensic Traumatology and other fields.The virtopsy must be considered not only as a postmortem procedure (complementing but not substituting the traditional autopsy), but a way to examine body parts in an interactive manner, whatever the subject is dead or alive. That spreads its utility and makes the method appropriate whenever an accurate, real-time, interactive and reproducible forensic anatomic examination is required.

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Three-Dimensional Visualization in Medicine and Biology

Cited by 34 publications

References 45 publications

Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry

Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry

Biomedical image visualization research using the Visible Human Datasets

Virtopsia: Aplicaciones de un nuevo método de inspección corporal no invasiva en ciencias forenses

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