Three‐dimensional Printing Approaches for the Treatment of Critical‐sized Bone Defects

Salehi, Sara; Naved, Bilal A.; Grayson, Warren L.

doi:10.1002/9781119242642.ch9

Cited by 2 publications

(4 citation statements)

References 139 publications

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“…Ink-based technologies include IJP [153], and aerosol jet printing (AJP) [154]. Comprehensive descriptions of these technologies can be found in [2,[155][156][157], to name a few. However, the operation mechanisms of these techniques and their advantages and limitations are briefly described here.…”

Section: D Printing Technologies Based On Stimulation Usedmentioning

confidence: 99%

Challenges on optimization of 3D-printed bone scaffolds

Bahraminasab

2020

BioMed Eng OnLine

145

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Background Bones in human body are prone to damage due to different causes such as fractures, diseases, and infections. Nevertheless, they have a remarkable capacity to repair and heal themselves after trauma and illness. Large defects, however, are never completely reinstated because their sizes are beyond the limit up to which the bones can repair [1]. In these conditions, therefore, a medical remedy is required to stabilize, align and support the damaged bone region to restore the lost function. Bone autografts are considered the gold standard treatment. However, they have a number of shortcomings including the limited sources and donor site morbidity. Allografts also have the risk of immune rejection and disease transmission [2, 3]. Therefore, the research has headed for other solutions via tissue engineering. Bone tissue engineering provides three-dimensional (3D)

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Section: D Printing Technologies Based On Stimulation Usedmentioning

confidence: 99%

Challenges on optimization of 3D-printed bone scaffolds

Bahraminasab

2020

BioMed Eng OnLine

145

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“… 6 Moreover, the geometric irregularities of bone defects make graft-defect matching extremely challenging. 7 …”

Section: Introductionmentioning

confidence: 99%

“…6 Moreover, the geometric irregularities of bone defects make graft-defect matching extremely challenging. 7 Tissue engineering has emerged as a promising technology that combines biomaterials, stem cells, and bioactive molecules to create synthetic bone tissue substitutes in an attempt to surmount the need for natural bone grafts. A successful tissueengineered bone graft capable of use for clinical application demands safe and biodegradable constructs retaining strong osteoconductive and osteoinductive capabilities that can practically restore relatively large-sized bone defects.…”

Section: Introductionmentioning

confidence: 99%

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Rat Calvarial Bone Regeneration by 3D-Printed β-Tricalcium Phosphate Incorporating MicroRNA-200c

Remy

Akkouch

et al. 2021

ACS Biomater. Sci. Eng.

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Advanced fabrication methods for bone grafts designed to match defect sites that combine biodegradable, osteoconductive materials with potent, osteoinductive biologics would significantly impact the clinical treatment of large bone defects. In this study, we engineered synthetic bone grafts using a hybrid approach that combined three-dimensional (3D-)printed biodegradable, osteoconductive β-tricalcium phosphate (β-TCP) with osteoinductive microRNA(miR)-200c. 3D-printed β-TCP scaffolds were fabricated utilizing a suspension-enclosing projection-stereolithography (SEPS) process to produce constructs with reproducible microarchitectures that enhanced the osteoconductive properties of β-TCP. Collagen coating on 3D-printed β-TCP scaffolds slowed the release of plasmid DNA encoding miR-200c compared to noncoated constructs. 3D-printed β-TCP scaffolds coated with miR-200c -incorporated collagen increased the transfection efficiency of miR-200c of both rat and human BMSCs and additionally increased osteogenic differentiation of hBMSCs in vitro . Furthermore, miR-200c -incorporated scaffolds significantly enhanced bone regeneration in critical-sized rat calvarial defects. These results strongly indicate that bone grafts combining SEPS 3D-printed osteoconductive biomaterial-based scaffolds with osteoinductive miR-200c can be used as superior bone substitutes for the clinical treatment of large bone defects.

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Three‐dimensional Printing Approaches for the Treatment of Critical‐sized Bone Defects

Cited by 2 publications

References 139 publications

Challenges on optimization of 3D-printed bone scaffolds

Challenges on optimization of 3D-printed bone scaffolds

Rat Calvarial Bone Regeneration by 3D-Printed β-Tricalcium Phosphate Incorporating MicroRNA-200c

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