Three-dimensional Optical Coherence Tomographic Findings of Idiopathic Multiple Serous Retinal Pigment Epithelial Detachment

Morphological changes in the retinal pigment epithelium on spectral-domain OCT in the unaffected eyes with idiopathic central serous chorioretinopathy

“…Recently changes in RPE in central serous chorioretinopathy (CSC) have been studied on OCT Fourier/spectral domain [10][11][12][13][14][15]. These studies have looked into the morphological changes occurring at the site of leakage in the symptomatic eye.…”

“…Several reports on fluorescein and indocyanine green angiography and multifocal electroretinography indicate that the disease process in ICSC is more diffuse and shows bilateral retinochoroidal dysfunction, even though the disease may be manifesting clinically only in one eye [4][5][6][7][8]. Though the etiology of ICSC remains unknown, it is postulated that the abnormalities in choroidal circulation make overlying retinal pigment epithelium (RPE) dysfunctional, resulting in the development of serous retinal detachment [7,9,10].…”

Three-dimensional optical coherence tomographic findings in central serous chorioretinopathy

“…OCT-ophthalmoscope (Ophthalmic Technologies, Inc, Toronto, ON, Canada) is a new system that is useful for analyzing structures of the posterior pole [15][16][17]19]. This instrument can capture information about the arbitrary depth of lesions in slices at orientations parallel to the retinal surface (en-face images, or C-scans).…”

Role of Optical Coherence Tomography in Central Serous Chorioretinopathy

“…Two recently published articles confirm the observation of multiple pigment epithelial defects and other retinal pigment epithelium abnormalities on optical coherence tomography in patients with central serous chorioretinopathy. [7] Out of 42 eyes that retinal pigment epithelium abnormality on optical coherence tomography, in 31(73.5%) eyes this retinal pigment epithelium abnormality exactly coincided with leakage points on fundus fluorescein angiography, which shows that it is this retinal pigment epithelium defect through which fluid leaks from choroid into the sub retinal space. Perkin, [8] et al postulated that pigment epithelial defects in central serous chorioretinopathy are a sign that larger areas of compromised retinal pigment epithelium are involved.…”