Three‐dimensional electrospun nanofibrous scaffolds for bone tissue engineering

Abstract

Electrospinning technology has been widely used in the past few decades to prepare nanofibrous scaffolds that mimic extracellular matrices. However, traditional two‐dimensional (2D) electrospun nanofibrous mats still have some inherent disadvantages for bone tissue engineering, such as limited cell infiltration and lack of three‐dimensional (3D) structure. The development of 3D electrospun scaffolds with larger pore sizes and porosity provides new perspectives for electrospinning‐based tissue engineering scaffolds. However, there are still some challenges and areas for improvement. In this review, the applications of 3D electrospun nanofibrous scaffolds in the field of bone tissue engineering from its fabrication methods to bio‐functionalization are summarized, with the aim of providing new insights into the design of electrospinning‐based bone tissue engineering scaffolds.

Nanofibrillar Decellularized Wharton's Jelly Matrix for Segmental Tracheal Repair

“…Therefore, it would be useful to determine the optimal mixing ratio of DWJM/PCL. Furthermore, the construction of a 3D tubular scaffold with controllable lumen diameter and wall thickness from 2D nanofibrous membranes is a technological problem that should be addressed before its further application in trachea tissue engineering 15. At present, limited progress has been achieved in addressing this problem 16.…”

“…Furthermore, the construction of a 3D tubular scaffold with controllable lumen diameter and wall thickness from 2D nanofibrous membranes is a technological problem that should be addressed before its further application in trachea tissue engineering. [15] At present, limited progress has been achieved in addressing this problem. [16] More importantly, no study to date has achieved segmental tracheal defect repair using a 2D DWJM/PCL nanofibrous membrane.…”

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

“…Acknowledging the beneficial features, the electrospun nanofibers offers great possibility in the regeneration of various tissues in the human body as depicted in the Figure 7 [101]. Therefore, to date enormous progress have shown that the electrospun based scaffolds are greatly enhanced the repair/regeneration of different of tissues (e.g., bone, skin, nerve, heart, vascular and muscoskeletal system) due to its inherent properties of large surface area, porosity, stacking/pattering nature, alignment, mechanical strength, complex interface topology and easy functionalization nature [31,47,[102][103][104][105][106][107][108]. Therefore, we evidently discuss potential of electrospun nanofibers in the engineering of various tissues in the following sections.…”

Recent Advances in Applications of Ceramic Nanofibers

“…Nanofibers are 1D nanostructured materials with some distinctive characteristics, such as large surface areas, well-controlled composition, flexibility, tunable porosity, ease of surface functionalization, and high mechanical/thermal properties which make them suitable for a number of different applications such as energy harvesting and storage [1,2], filtration [3,4], sensors [5,6], tissue engineering [7][8][9], wound healing [10,11], drug delivery [12,13], polymer reinforcement [14,15], and so on.…”