Three cases with light-induced retinopathy

Harada, Taishi; Koizumi, E; Saito, Akira; Sugita, Kimiko; Hisada, Hiromoto; Awaya, S

doi:10.1007/bf00154414

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…There are countless reports of light damage resulting from cataract surgery, during which the light illuminating the crystalline lens also exposes the retina; for example, (Boldrey et al 1984, Harada et al 1988, Knox Cartwright et al 2007, McDonald and Irvine. 1983, Menezo et al 2002).…”

Section: Factors Affecting Susceptibility To Phototoxicitymentioning

confidence: 99%

The susceptibility of the retina to photochemical damage from visible light

Hunter

Morgan

Merigan

et al. 2012

Progress in Retinal and Eye Research

307

261

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The photoreceptor/RPE complex must maintain a delicate balance between maximizing the absorption of photons for vision and retinal image quality while simultaneously minimizing the risk of photodamage when exposed to bright light. We review the recent discovery of two new effects of light exposure on the photoreceptor/RPE complex in the context of current thinking about the causes of retinal phototoxicity. These effects are autofluorescence photobleaching in which exposure to bright light reduces lipofuscin autofluorescence and, at higher light levels, RPE disruption in which the pattern of autofluorescence is permanently altered following light exposure. Both effects occur following exposure to visible light at irradiances that were previously thought to be safe. Photopigment, retinoids involved in the visual cycle, and bisretinoids in lipofuscin have been implicated as possible photosensitizers for photochemical damage. The mechanism of RPE disruption may follow either of these paths. On the other hand, autofluorescence photobleaching is likely an indicator of photooxidation of lipofuscin. The permanent changes inherent in RPE disruption might require modification of the light safety standards. AF photobleaching recovers after several hours although the mechanisms by which this occurs are not yet clear. Understanding the mechanisms of phototoxicity is all the more important given the potential for increased susceptibility in the presence of ocular diseases that affect either the visual cycle and/or lipofuscin accumulation. In addition, knowledge of photochemical mechanisms can improve our understanding of some disease processes that may be influenced by light exposure, such as some forms of Leber’s congenital amaurosis, and aid in the development of new therapies. Such treatment prior to intentional light exposures, as in ophthalmic examinations or surgeries, could provide an effective preventative strategy.

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Section: Factors Affecting Susceptibility To Phototoxicitymentioning

confidence: 99%

The susceptibility of the retina to photochemical damage from visible light

Hunter

Morgan

Merigan

et al. 2012

Progress in Retinal and Eye Research

307

261

View full text Add to dashboard Cite

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“…McDonald and Irvine [1] reported light-induced maculopathy caused by the operating microscope in extracapsular cataract extraction. Harada and coworkers [9] described three patients with 'light-induced retinopathy' when a video recording device was used in connection with an operating microscope. Robertson and Feldman [10] demonstrated a cause-and-effect relationship between the light of an operating microscope and macular lesions in human eyes.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative retinal light damage reflected in electrophysiologic data

et al. 1991

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In a series of 30 unilaterally pseudophakic patients, electroretinograms and electrooculograms were recorded 6 months postoperatively. The unoperated on fellow eyes served as controls. High intraoperative retinal light exposure (3.4-7.3 mW/cm2, Zeiss OPMI6 operating microscope) caused a substantial reduction of electrophysiologic potentials. Light protection prevented deterioration of electroretinogram and electro-oculogram potentials; reducing the bulb voltage, tilting the axis of illumination, filtering short wavelengths and the use of light shields resulted in 4-log-unit lower intensities (0.8-3.7 microW/cm2).

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“…gov.uk). Excessive exposure to light has been shown to cause damage to the retina in animal models (Albert et al 2010) and case reports of operating light exposure (Harada et al 1988). Epidemiological studies, however, have failed to show a significant association between cumulative light exposure and AMD (Tomany et al 2004;Khan et al 2006).…”

Section: Referencesmentioning

confidence: 99%