Intraoperative retinal light damage reflected in electrophysiologic data

Lessel, M. R.; Thaler, A.; Heilig, P.; Jantsch, W.; Scheiber, V.

doi:10.1007/bf00142670

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…On the other hand, the visual loss and retinal scarring observed in 18 patients that viewed a solar eclipse required weeks to months to heal, and often produced permanent damage (MacFaul, 1969). Retinal light damage produced by the illumination used during eye surgeries such as cataract removal (Knox Cartwright et al, 2007; Lessel et al, 1991) can produce long lasting defects in focal electroretinogram or visual perimetry, although loss following threshold laser photocoagulation in human subjects (Roider et al, 1999) often resolved from one week to a few months after treatment. The success of high-resolution OCT in examining retinal cellular structure in this study suggests that this method may be effective for detecting outer retinal damage in humans.…”

Section: Discussionmentioning

confidence: 99%

Focal damage to macaque photoreceptors produces persistent visual loss

Strazzeri

Hunter

Masella

et al. 2014

Experimental Eye Research

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Insertion of light-gated channels into inner retina neurons restores neural light responses, light evoked potentials, visual optomotor responses and visually-guided maze behavior in mice blinded by retinal degeneration. This method of vision restoration bypasses damaged outer retina, providing stimulation directly to retinal ganglion cells in inner retina. The approach is similar to that of electronic visual protheses, but may offer some advantages, such as avoidance of complex surgery and direct targeting of many thousands of neurons. However, the promise of this technique for restoring human vision remains uncertain because rodent animal models, in which it has been largely developed, are not ideal for evaluating visual perception. On the other hand, psychophysical vision studies in macaque can be used to evaluate different approaches to vision restoration in humans. Furthermore, it has not been possible to test vision restoration in macaques, the optimal model for human-like vision, because there has been no macaque model of outer retina degeneration. In this study, we describe development of a macaque model of photoreceptor degeneration that can in future studies be used to test restoration of perception by visual prostheses. Our results show that perceptual deficits caused by focal light damage are restricted to locations at which photoreceptors are damaged, that optical coherence tomography (OCT) can be used to track such lesions, and that adaptive optics retinal imaging, which we recently used for in vivo recording of ganglion cell function, can be used in future studies to examine these lesions.

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Section: Discussionmentioning

confidence: 99%

Focal damage to macaque photoreceptors produces persistent visual loss

Strazzeri

Hunter

Masella

et al. 2014

Experimental Eye Research

View full text Add to dashboard Cite

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“…A retinal photochemical hazard appears critical without appropriate filters, permitting only short exposure time (Michael et al 2004). After light exposure of the retina during cataract surgery amplitude decrease of electroretinogram and electro-oculogram (EOG) could be observed (Lessel et al 1991), the EOG particularly reflecting the phototoxic damages at the level of the RPE.…”

Section: Discussionmentioning

confidence: 99%