Thiouracil Treatment of Angina Pectoris

Additive Effects of Iodine and Thiourea in the Treatment of Hyperthyroidism 1

“…There certainly is a time as well as a dosage factor involved in the action of the drug. The experience with thiouracil in normal subjects is interesting in this respect, since it required weeks or months to induce hypothyroidism, even with large doses (18,19).…”

Myocardial Metabolism in the Pathogenesis and Treatment of Angina Pectoris

“…The thyroid hormone affects the myocardial metabolism by markedly potentiating the hypoxia-producing calorigenic and toxic action of the adreno-sympathogenic catecholamines (36,44,60), possibly also by intensifying the intramyocardial liberation of epinephrine from local chromaffine elements (24). Conversely, thyroid inactivation protects the heart muscle against these chemical effects and diminishes the cardiac sensitivity to the catecholamines (12,24,44,57,61,62).…”

“…Conversely, thyroid inactivation protects the heart muscle against these chemical effects and diminishes the cardiac sensitivity to the catecholamines (12,24,44,57,61,62). The recently discovered fact that the thyroid hormone reduces the available amine oxidase which destroys the sympathomimetic catecholamines (7 a, 63 a) suggests that the "potentiation" of these catecholamines is es sentially due to a delay in their enzymatic inactivation.…”

Thiouracil in hyperthyroidism**Formerly, Director of Technical Service, Pharmaceutical Dept., Calco Chemical Division.

“…More recently, another investigator (28) has suggested that the therapeutic efficacy of thiouracil, in seven out of a series of 10 patients with angina pectoris, makes the drug appear as a valuable and preferable substitute for thyroidectomy. For instance, one report (12) mentions that the drug may be useful in very severe chronic congestive heart failure.…”