Myocardial Metabolism in the Pathogenesis and Treatment of Angina Pectoris

Raab, W.

doi:10.1159/000165291

Cited by 17 publications

(3 citation statements)

References 3 publications

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“…However, while most other pharmacological groups tried to increase the oxygen supply to the heart -in particular with substances that dilate the blood vessels -, Black instead looked for a substance that lowered the cardial oxygen consumption. This strategy coincided with the proposal of Wilhelm Raab that the release of adrenergic substances leads to an oxygen consumption of the heart that is much higher than required by the cardiac work alone (Raab 1953). Again, until the first administration of pronethalol to a patient, this therapeutic hypothesis, even though based on a number of observations, was very much that: a hypothesis (Black 1989, Stapleton 1997, Vos, 1991.…”

Section: Rationality Experiments and Hypothesesmentioning

confidence: 53%

Integrating research and development: the emergence of rational drug design in the pharmaceutical industry

Adam

2005

Studies in History and Philosophy of Science Part C: Studies in

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Appears in Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2005). AbstractRational drug design is a method for developing new pharmaceuticals that typically involves the elucidation of fundamental physiological mechanisms. It thus combines the quest for a scientific understanding of natural phenomena with the design of useful technology and hence integrates epistemic and practical aims of research and development. Case studies of the rational design of the cardiovascular drugs propranolol, captopril and losartan provide insights into characteristics and conditions of this integration. Rational drug design became possible in the 1950s when theoretical knowledge of drug-target interaction and experimental drug testing could interlock in cycles of mutual advancement. The integration does not, however, diminish the importance of basic research for pharmaceutical development. Rather, it can be shown that still in the 1990s, linear processes of innovation and the close combination of practical and epistemic work were interdependent.

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Section: Rationality Experiments and Hypothesesmentioning

confidence: 53%

Integrating research and development: the emergence of rational drug design in the pharmaceutical industry

Adam

2005

Studies in History and Philosophy of Science Part C: Studies in

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“…Shimanato (1959) induced a fibrous type of atheroma with myocardial infarct-like lesions and encepholomalacia in rabbits by administering serotonin and adrenalin. Raab (1953) has demonstrated that sympathotropic catecholamines induced by strain and emotion have a specific oxygen-wasting chemical affect on the heart inducing myocardial hypoxia and destructive changes. Rosenman & Friedman (1957) and Peterson, Wilcox, Haley & Keith (1960) have found an increase in the serum cholesterol under emotional stress.…”

Section: Emotion and An Acute Cardiovascularmentioning

confidence: 99%

Emotion and atherosclerotic heart disease

Sigler

1967

British Journal of Medical Psychology

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“…DR. BLUMGART: Eighty-four of our patients have been followed long enough for evaluation: 36 (43 per cent) had an excellent result, 20 (24 per cent) had a worthwhile result, and 28 (83 per cent) had no benefit. Figure 1 shows these results as well as those previously reported from 49 other clinics.…”

mentioning

confidence: 93%