Thioether-terminated triazole-bridged covalent organic framework for dual-sensitive drug delivery application

Anbazhagan, Rajeshkumar; Krishnamoorthi, Rajakumari; Kumaresan, Swedha; Tsai, Hsieh‐Chih

doi:10.1016/j.msec.2020.111704

Cited by 30 publications

(22 citation statements)

References 43 publications

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“…Tsai and co-workers reported a novel thioether-terminated triazole bridge-containing covalent organic framework (TCOF) constructed via simple click chemistry between 1,3,5-tribromobenzene and triethylamine. [82] It is worth noting that TCOF-PEG additive could adsorb DOX in more than one way, that is, electrostatic and hydrogen bond adsorption in the pores of TCOF-PEG, respectively. In addition, there were two ways of drug release, including hydrogen bond protonation releasing and structure tautomerism releasing of drugs (Figure 9).…”

Section: Cof Materials For Drug Deliverymentioning

confidence: 99%

Covalent Organic Frameworks (COFs): A Necessary Choice For Drug Delivery

et al. 2022

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Some drug molecules with strong chemical activity are unstable in the biological environment and difficult to reach the target, so no matter how good the drug is, it cannot completely prove its efficacy. And drugs need good vectors to help them deliver to their target, where they work best. In recent years, covalent organic frameworks (COFs) have been developed for drug delivery applications due to their regular pore structure, good biocompatibility, topological controllability, and modifiability. In the process of drug delivery, COFs have many advantages such as high drug adsorption capacity, good stability in the biological environment, strong targeting of lesions, and weak cytotoxicity. At present, a lot of work using COFs as drug molecular carriers has been reported, and this minireview summarizes the mechanism of COFs drug delivery and related applications in recent years (drug adsorption and release), by which we expect to achieve more ideas for the future design of drug delivery related COFs and push forward the development of COFs in drug delivery.

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Section: Cof Materials For Drug Deliverymentioning

confidence: 99%

Covalent Organic Frameworks (COFs): A Necessary Choice For Drug Delivery

et al. 2022

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“…The TCOF was sensitive to pH and processed biocompatibility toward HeLa cells. 23 All these studies demonstrated that COF as novel are potential in drug delivery for therapeutic applications.…”

Section: Introductionmentioning

confidence: 97%

Synthesis of pH-responsive covalent organic frameworks nanocarrier for plumbagin delivery

2022

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“…As the latest member of the group of renowned crystalline porous materials, covalent organic frameworks (COFs) have been at the forefront of materials science in numerous fields owing to their unique structural features and excellent properties, such as catalysis, 1–4 drug delivery, 5–8 energy storage 9–11 and environmental remediation. 12,13 Currently, the synthesis of various COFs is generally dominated by solvothermal methods, which is mainly shown by the universality of the strategy, the high yield and the high crystallinity of the products.…”

Section: Introductionmentioning

confidence: 99%