Synthesis of pH-responsive covalent organic frameworks nanocarrier for plumbagin delivery

Wang, Yang; Sun, Xin; Wang, Yi

doi:10.1039/d2ra03127b

Cited by 12 publications

(5 citation statements)

References 29 publications

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“…This work is the first to demonstrate the use of COF materials in drug delivery. Their pioneering work has paved the way for the application of COFs to the field of drug delivery, and a number of additional functionalized COFs were developed to boost drug delivery efficiency in nanodrug delivery systems (NDDSs) [ 130 – 137 , 144 ].…”

Section: Pnps For Oral Insulin Deliverymentioning

confidence: 99%

Polymeric nanoparticles (PNPs) for oral delivery of insulin

Wang,

Li,

Rasool

et al. 2024

J Nanobiotechnol

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Successful oral insulin administration can considerably enhance the quality of life (QOL) of diabetes patients who must frequently take insulin injections. Oral insulin administration, on the other hand, is seriously hampered by gastrointestinal enzymes, wide pH range, mucus and mucosal layers, which limit insulin oral bioavailability to ≤ 2%. Therefore, a large number of technological solutions have been proposed to increase the oral bioavailability of insulin, in which polymeric nanoparticles (PNPs) are highly promising for oral insulin delivery. The recently published research articles chosen for this review are based on applications of PNPs with strong future potential in oral insulin delivery, and do not cover all related work. In this review, we will summarize the controlled release mechanisms of oral insulin delivery, latest oral insulin delivery applications of PNPs nanocarrier, challenges and prospect. This review will serve as a guide to the future investigators who wish to engineer and study PNPs as oral insulin delivery systems. Graphical Abstract

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Section: Pnps For Oral Insulin Deliverymentioning

confidence: 99%

Polymeric nanoparticles (PNPs) for oral delivery of insulin

Wang,

Li,

Rasool

et al. 2024

J Nanobiotechnol

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“…The pH-controlled delivery was due to the dissolution of COF-366, where COF-366 was partially destroyed under acidic conditions, as evident by its BET surface area, which was reduced to 420 m 2 g À1 after the unloading of the drug. 168 In this case, the fate of the degraded COF scaffold should be investigated.…”

Section: Miscellaneous Drug Delivery Using Cofsmentioning

confidence: 99%

Drug delivery using biocompatible covalent organic frameworks (COFs) towards a therapeutic approach

Ghosh,

Banerjee

2023

Chem. Commun.

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“…Ge et al developed hypoxia sensitive azo bond containing nanoscale COF followed by immobilization of PS Ce6 and Tirapazamin (TPZ) for NIR-light mediated drug delivery [21]. Wang et al synthesized nanoscale COF-366 for the encapsulation of plumbagin (PLB) with loading capacity 16.3 wt% and pH responsive PLB delivery as well as cytotoxicity towards pancreatic cancer cells [22]. Xu et al developed acetal-linked POPs HCTP-MA via condensation reaction.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled nanoscale upconversion POP composite for hypoxia relieving and enhanced chemotherapy in hepatocellular carcinoma

Mukherjee,

Guha,

Ghosh

et al. 2024

Preprint

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Uncontrolled proliferations and altered metabolism of cancer cells result an imbalance of nutrients as well as oxygen supply and persuade hypoxia. This hypoxia in turn activates the transcription gene HIF-1α which eventually upregulates the efflux transporter P-gp and induce MDR. Thus, hypoxia leads to resistance towards conventional therapy methods. Therefore, the fabrication of a nanoscale porous system enriched with upconversion nanoparticle to target the cancer cells, evade hypoxia and enhanced anticancer therapy is the key goal of this chapter. Herein, the upconversion nanoparticles are embedded with the nanoscale POP and further conjugated with targeting moiety and also with catalase molecule. The nanoscale POP embedded with UCNPs are generated in room temperature. Targeting ligand lactobionic acid is attached after polymer coating which effectively targets liver cancer cells. Then catalase is grafted effectively produces oxygen. The endogenously generated oxygen alleviates the hypoxia of the liver cancer cells. The drug and catalase-loaded composite exhibits more cytotoxicity in case of hypoxic liver cells than the normal cells by overcoming hypoxia and downregulating the hypoxia inducible factors.

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Synthesis of pH-responsive covalent organic frameworks nanocarrier for plumbagin delivery

Abstract: A nanoscale covalent organic framework encapsulating plumbagin was synthesized with a high pH-sensitive drug release performance.

Cited by 12 publications

References 29 publications

Polymeric nanoparticles (PNPs) for oral delivery of insulin

Polymeric nanoparticles (PNPs) for oral delivery of insulin

Drug delivery using biocompatible covalent organic frameworks (COFs) towards a therapeutic approach

Self-assembled nanoscale upconversion POP composite for hypoxia relieving and enhanced chemotherapy in hepatocellular carcinoma

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