Thinning of the inner and outer retinal layers, including the ganglion cell layer and photoreceptor layers, in obstructive sleep apnea and hypopnea syndrome unrelated to the disease severity

Güven, Soner; Kılıç, Deniz; Bolattürk, Ömer Faruk

doi:10.1007/s10792-021-01937-4

Cited by 5 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, IOP was significantly higher in patients in the more severe OSA group than those with mild OSA ( P =0.001). Similar results were found in the studies conducted by Guven et al44 and Xin et al45 The decrease in ocular perfusion pressure in OSA patients results in raised IOP. IOP is the most important known risk factor for the onset and progression of glaucoma.…”

Section: Discussionsupporting

confidence: 89%

Retinal Nerve Fiber Layer Thickness in Patients With Obstructive Sleep Apnea

Devi

Agrawal

Gupta

et al. 2023

Journal of Glaucoma

View full text Add to dashboard Cite

Précis: Average and superior quadrant retinal nerve fiber layer thickness (RNFLT) was lower in the more severe obstructive sleep apnea (OSA) group and inversely associated with apnea-hypopnea index (AHI). OSA may have an impact on RNFLT.Purpose: The purpose of this study was to study the RNFLT using optical coherence tomography (OCT) in patients with different severities of OSA.Patients and Methods: In this hospital-based prospective crosssectional study, 90 (90 eyes) newly diagnosed OSA patients aged 18 years or above were enrolled. Based on the AHI, there were 38.8%, 30%, and 31.1% cases of mild (AHI ≥ 5 to <15), moderate (AHI ≥ 15 to <30), and severe (AHI ≥ 30) OSA, respectively. All the participants underwent a comprehensive ocular examination. OCT was done using CIRRUS HD-OCT 500 to measure the RNFLT. Results:The average RNFLT among the 3 OSA groups was significantly different (P = 0.002) and inversely associated with AHI (P = 0.02, r s = −0.16). Severe OSA had thinner average RNFLT than those with mild and moderate OSA (P = 0.01 and 0.003, respectively). Among the 4 quadrants observed, only the superior quadrant RNFLT among the 3 OSA groups was significantly different (P < 0.00001) and inversely associated with AHI (P = 0.01, r s = −0.17). Severe OSA had thinner superior quadrant RNFLT than those with moderate OSA (P < 0.01). The differences in the intraocular pressure among the 3 OSA groups were statistically significant (P < 0.0008). Patients with moderate and severe OSA had higher intraocular pressure than patients with mild OSA (P = 0.002 and 0.001, respectively).Conclusions: Attention should be paid to the patients with OSA as it may have an impact on RNFLT. OSA patients should be screened for glaucoma as early detection of glaucoma can reduce vision loss in these patients.

show abstract

Section: Discussionsupporting

confidence: 89%

Retinal Nerve Fiber Layer Thickness in Patients With Obstructive Sleep Apnea

Devi

Agrawal

Gupta

et al. 2023

Journal of Glaucoma

View full text Add to dashboard Cite

show abstract

“…Lin et al [19], Sagiv et al [24], and Ngoo et al [43] observed a decrease in the average peripapillary RNFL thickness and the superior, inferior, and temporal quadrant thicknesses in OSAS patients compared to those in healthy subjects. On the contrary, Casas et al [20] and Guven et al [44] found a decrease in the RNFL thickness just in the nasal quadrant in OSAS patients, whereas Adam et al [21] and Kücük et al [42] did not find any significant difference in RNFL thickness between OSAS patients and healthy controls. In the present study, we observed that baseline macular thicknesses and average RNFL thicknesses were significantly lower in severe OSAS than in mild-moderate OSAS, as found by Yu et al [29].…”

Section: Discussionmentioning

confidence: 91%

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Tejero-Garcés

Puyuelo

Casas

et al. 2022

JCM

View full text Add to dashboard Cite

Retinal findings may change in patients with obstructive sleep apnea syndrome (OSAS). The present study aims to evaluate several retinal findings, such as macula layer thickness, the peripapillary retinal nerve fiber layer, and the optic nerve head in patients with OSAS, using optical coherence tomography (OCT); it also aims to monitor the result of several types of treatment of OSAS with OCT. A prospective comparative study was designed. Patients were recruited at a Sleep Unit of a University Hospital and underwent comprehensive ophthalmological examinations. Following exclusion criteria, fifty-two patients with OSAS were finally included. Patients were examined by OCT twice: once before treatment, and again after six months of treatment. In mild–moderate patients, where retinal swelling had been demonstrated, retinal thicknesses decreased [fovea (p = 0.026), as did inner ring macula (p = 0.007), outer ring macula (p = 0.015), and macular volume (p = 0.015)]. In severe patients, where retinal atrophy had been observed, retinal thickness increased [fovea (p < 0.001)]. No statistically significant differences in efficacy between treatments were demonstrated. In conclusion, OCT can evaluate the retina in patients with OSAS and help to monitor results after treatment. In severe OSAS, retinal thickness increased six months after treatment.

show abstract

“…[14], Sagiv et al [19], and Ngoo et al [34] observed a decrease in the average peripapillary RNFL thickness and the superior, inferior, and temporal quadrant thicknesses in OSAS patients compared to those in healthy subjects. On the contrary, Casas et al [15] and Guven et al [35] found a decrease of the RNFL thickness just in the nasal quadrant in OSAS patients, whereas Adam et al [16 and] Kücük et al [34] did not find any significant difference in RNFL thickness between OSAS patients and healthy controls. In the present study, we observed baseline macular and average RNFL thicknesses were significantly lower in severe OSAS than in mild-moderate OSAS, as found by Yu et al [24].…”

Section: Discussionmentioning

confidence: 92%

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Tejero-Garcés¹,

Puyuelo²,

Casas³

et al. 2021

Preprint

View full text Add to dashboard Cite

Retinal findings may change in patients with obstructive sleep apnea syndrome (OSAS). The present study aims to evaluate several retinal findings such as macula layer thickness, peripapillary retinal nerve fiber layer, and the optic nerve head in patients with OSAS using optical coherence tomography (OCT) and monitor the result of several types of treatment of OSAS with OCT. A prospective comparative study was designed. Patients were recruited at a Sleep Unit of a University Hospital and underwent comprehensive ophthalmological examinations. Following exclusion criteria, fifty-two patients with OSAS were finally included. Patients were examined by OCT twice: first, before treatment; secondly, after six months of treatment. In mild-moderate patients, where retinal swelling has been demonstrated, retinal thicknesses decreased [fovea (p=0.026), as well as inner ring macula (p=0.007), outer ring macula (p=0.015), and macular volume (p=0.015)]. In severe patients, where retinal atrophy had been observed, retinal thickness increased [fovea (p&lt;0.001)]. No statistically significant differences in efficacy between treatments were demonstrated. In conclusion, OCT can evaluate the retina in patients with OSAS and help monitor results after treatment. In severe OSAS, retinal thickness increased six months after treatment.

show abstract

Thinning of the inner and outer retinal layers, including the ganglion cell layer and photoreceptor layers, in obstructive sleep apnea and hypopnea syndrome unrelated to the disease severity

Cited by 5 publications

References 32 publications

Retinal Nerve Fiber Layer Thickness in Patients With Obstructive Sleep Apnea

Retinal Nerve Fiber Layer Thickness in Patients With Obstructive Sleep Apnea

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Contact Info

Product

Resources

About