Consistent with its effects in patients with Type 2 diabetes, rosiglitazone substantially improved whole body insulin sensitivity and the glycaemic and insulinaemic responses to an OGTT and meal tolerance test in subjects with persistent IGT. Furthermore, rosiglitazone reduced systolic and diastolic ambulatory blood pressure in these subjects.

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Haemodynamically significant systemic-to-pulmonary artery collaterals may present as a cause of cardiorespiratory compromise in tetralogy of Fallot (TOF) with pulmonary atresia. We present here a case of TOF with pulmonary atresia with aneurysmally dilated aorto-pulmonary collateral causing compression over trachea, presenting as dry irritating cough who died suddenly with haemoptysis probably due to rupture of hypertrophied bronchial collaterals or direct erosion of large major aorto-pulmonary collateral arteries (MAPCA) into the respiratory tract.

A 12-year-old girl developed acute frontal headache and severe visual loss in both eyes. A presumptive diagnosis of pituitary abscess was made on the basis of suggestive magnetic resonance imaging findings. These consisted of a large non-enhancing area within the pituitary gland and thin irregular glandular rim enhancement. There was no evidence of pre-existing intracranial or systemic infection. The patient recovered completely after treatment with intravenous and oral antibiotics without surgical drainage. This case highlights the need for a high index of suspicion for pituitary abscess based on unusual imaging findings even when there is no source of infection.

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Introduction: The impact of Meibomian gland dysfunction (MGD) on the overall health of the patient is not known. Efforts are being made to understand the association of dyslipidemia with MGD. The objective of the study was to determine the association of dyslipidemia with the severity of MGD, a contributor to dry eye syndrome. Materials and methods: We performed an observational case-control study at a tertiary care centre over 18 months and enrolled 116 patients in the age group of 18 to 65 years. A detailed history and clinical examination were done. Following examination, patients were allocated into two groups, patients with MGD and no history of dyslipidemia (cases) and patients without MGD and no history of dyslipidemia (controls). A fasting lipid profile was done for both these groups. The data were subsequently analyzed with SPSS software. Results: Fifty six (48.3%) of the participants had serum total cholesterol levels ≥200 mg/dl, with a significant association between higher cholesterol levels and severity of MGD (p=0.0001). 77 (66.4%) of the participants had serum triglycerides levels of ≥150 mg/ dl. There was a significant association between the severity of MGD and elevated triglyceride levels (95% confidence interval of Pearson’s chi-square 28.16, p=0.0001). A significant association was also observed between the severity of MGD and elevated LDL levels (95% confidence interval of Pearson’s chi-square 5.95, p=0.015). However, no association was found between HDL levels and the severity of MGD. Conclusion: The results suggest that patients with MGD and without any history of dyslipidemia, may have higher blood levels of lipid profile components as compared to age-matched controls.