Pharmacological investigations on adaptation in rats subjected to cold water immersion stress

Agrawal, Ajai; Jaggi, Amteshwar Singh; Singh, Nirmal

doi:10.1016/j.physbeh.2011.02.014

Cited by 40 publications

(19 citation statements)

References 41 publications

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“…Therefore, the number of counts is directly related to the movement of animals inside the actophotometer chamber. The animals were placed in the actophotometer for 10 min and their activity was assessed in terms of count per 10 min [2,21].…”

Section: Actophotometer Testmentioning

confidence: 99%

“…Each mouse was exposed to the open field test for 10 min in a dimly light room. The mice were placed in the center of the open field and the number of line crossings and rearings were noted [2].…”

Section: Open Field Testmentioning

confidence: 99%

“…The animals were assessed for head dipping and rearing [2,22]. The low number of head dipping reflects the high anxiety state level and the number of rearings represents the exploration in the novel surrounding.…”

Section: Hole-board Testmentioning

confidence: 99%

“…Furthermore, it has been assumed to be involved in the pathophysiology of a variety of diseases, including anxiety, depression, post-traumatic stress disorder and memory loss [1]. However, individuals have an inherent capacity to cope with stress in the form of stress adaptation [2,3] and there is a reduction in the sensitivity of stress responsive elements, including the hypothalamicpituitary-adrenal (HPA) axis during repeated stress episodes [4]. Indeed, the blunted response of a body to the stress stimulus in the form of stress adaptation is a key protective mechanism against repeated stress exposure [5].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, the blunted response of a body to the stress stimulus in the form of stress adaptation is a key protective mechanism against repeated stress exposure [5]. In experimental settings, stress adaptation is characterized in terms of the restoration of behavioral alterations and the normalization of neuroendocrinological changes in comparison with the initial stress response [2,6]. Despite the knowledge of the existence of stress adaptation in animals and humans, the precise molecular signaling pathways involved in stress adaptive processes are not delineated.…”

Section: Introductionmentioning

confidence: 99%

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Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice

Bali

Jaggi

2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: The present study was designed to explore the anti-stress role of AR-A014418, a selective glycogen synthase kinase-3β inhibitor (GSK-3β), on changes provoked by immobilization stress of varying duration. Methods: Acute stress of varying degree was induced by subjecting mice to immobilization stress of short duration (30 min) or long duration (120 min). Thereafter, these animals were exposed to the same stressor for 5 days to induce stress adaptation. The behavioral alterations were assessed using an actophotometer, a hole-board, and the open field and social interaction tests. The serum corticosterone levels were assessed as markers of the hypothalamic-pituitary-adrenal (HPA) axis activity. The levels of total GSK-3β and p-GSK-3β-S9 were determined in the prefrontal cortex. Results: A single exposure to short or long immobilization stress produced behavioral and biochemical changes and the levels of p-GSK-3β-S9 decreased without affecting the total GSK-3β levels in the brain. However, repeated exposure to both short and long stress reversed the behavioral and biochemical changes along with the normalization of p-GSK-3β-S9 levels. The administration of AR-A014418, a selective GSK-3β inhibitor, diminished acute stress-induced behavioral and biochemical changes. Furthermore, AR-A014418 normalized acute stress-induced alterations in p-GSK-3β-S9 levels without changing total GSK-3β levels. Conclusions: Our study suggests that acute stress-induced decrease in p-GSK-3β-S9 levels in the brain contributes to the development of behavioral and biochemical alterations and the normalization of GSK-3β signaling may contribute to stress adaptive behavior in mice which have been subjected to repeated immobilization stress.

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Section: Actophotometer Testmentioning

confidence: 99%

Section: Open Field Testmentioning

confidence: 99%

Section: Hole-board Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice

Bali

Jaggi

2017

Journal of Basic and Clinical Physiology and Pharmacology

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Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

Kaur

Bali

Singh

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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The present study was designed to investigate the antistress effect of furosemide (sodium potassium chloride co-transporter inhibitor) in immobilization and foot-shock stress-induced behavioral alterations in the mice. Acute stress was induced in Swiss albino mice either by applying electric foot shocks of 0.6-mA intensity of 1-s duration with 30-s inter-shock interval for 1 h or immobilizing for 150 min. The acute stress-induced behavioral changes were assessed by using actophotometer, hole board, open-field, and social interaction tests. Biochemically, the corticosterone levels were estimated in the serum as a biomarker of hypothalamus-pituitary-adrenal (HPA) axis. Acute stress resulted in the development of behavioral alterations and elevation of the corticosterone levels. Intraperitoneal administration of furosemide (25 and 50 mg/kg) significantly attenuated immobilization and foot-shock stress-induced behavioral changes along with normalization of the corticosterone levels. It may be concluded that furosemide produces beneficial effects in reestablishing the behavioral and biochemical alterations in immobilization and foot-shock-induced acute stress in mice.

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Exploring the anti-stress effects of imatinib and tetrabenazine in cold-water immersion-induced acute stress in mice

Kumar

Singh

Jaggi

2020

Naunyn-Schmiedeberg's Arch Pharmacol

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Pharmacological investigations on adaptation in rats subjected to cold water immersion stress

Cited by 40 publications

References 41 publications

Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice

Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice

Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

Exploring the anti-stress effects of imatinib and tetrabenazine in cold-water immersion-induced acute stress in mice

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