Thin-Film Multiple Electrode Probes: Possibilities and Limitations

Prohaska, O.; Olcaytug, F.; Pfundner, P.; Dragaun, H.

doi:10.1109/tbme.1986.325894

Cited by 93 publications

(27 citation statements)

References 20 publications

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“…In the case where the same electrical signal is simultaneously recorded on 36 of the 37 microelectrodes of the array, the crosstalk signal on the 37th microelectrode could be as high as at 100 Hz. At first sight, this perturbation level may seem unacceptable [32], however, for the particular application of measuring streaming potentials of cartilage, much of the frequency content of the signal is below 30 Hz. In this frequency range, the crosstalk induced by one electrode is lower than 0.1% [ Fig.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and Characterization of Nonplanar Microelectrode Array Circuits for Use in Arthroscopic Diagnosis of Cartilage Diseases

Quenneville

Binette

Garon

et al. 2004

IEEE Trans. Biomed. Eng.

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Abstract-A process to fabricate nonplanar microelectrode array circuits was developed and the microelectrodes were characterized. These platinum microelectrode arrays are for recording streaming potential signals generated during indentation of articular cartilage. The nonplanar substrate was produced by permanent deformation of a 7-in-diameter circular stainless-steel wafer to form 32 semi-spherical caps

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Section: Discussionmentioning

confidence: 99%

Fabrication and Characterization of Nonplanar Microelectrode Array Circuits for Use in Arthroscopic Diagnosis of Cartilage Diseases

Quenneville

Binette

Garon

et al. 2004

IEEE Trans. Biomed. Eng.

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“…Over the past several decades, studies of electroactive cells have been carried out by using a variety of recording techniques, including glass micropipette intracellular and patch-clamp electrodes (1,3), voltage-sensitive dyes (4,5), multielectrode arrays (MEAs) (6)(7)(8), and planar FETs (9)(10)(11). The latter 2 recording techniques use welldeveloped microfabrication methods to allow for direct multiplexed detection on a scale not possible with micropipette technology, although the MEAs and FETs exhibit limited signalto-noise ratios (S/N) and detection areas that make cellular and subcellular recording difficult (12,13).…”

mentioning

confidence: 99%

Flexible electrical recording from cells using nanowire transistor arrays

Cohen‐Karni

Timko²,

Weiss³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

210

213

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“…Specifically, in previous studies the device or electrode density defined by fabrication process, could be used to describe the true signal spatial resolution -that is the distance at which distinct signals can be resolved by adjacent detectors. Moreover, scaling down the size of individual metal electrodes to achieve more localized detection is difficult due to corresponding increases in their impedance (7,8) that intrinsically limits the resolution of such passive recordings. Voltage-and calcium-sensitive optical dyes can provide excellent temporal and spatial resolution over wide fields (9, 10) but typically not simultaneously.…”

mentioning

confidence: 99%

Nanowire transistor arrays for mapping neural circuits in acute brain slices

Qing¹,

Pal²,

Tian³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

186

171

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Revealing the functional connectivity in natural neuronal networks is central to understanding circuits in the brain. Here, we show that silicon nanowire field-effect transistor (Si NWFET) arrays fabricated on transparent substrates can be reliably interfaced to acute brain slices. NWFET arrays were readily designed to record across a wide range of length scales, while the transparent device chips enabled imaging of individual cell bodies and identification of areas of healthy neurons at both upper and lower tissue surfaces. Simultaneous NWFET and patch clamp studies enabled unambiguous identification of action potential signals, with additional features detected at earlier times by the nanodevices. NWFET recording at different positions in the absence and presence of synaptic and ion-channel blockers enabled assignment of these features to presynaptic firing and postsynaptic depolarization from regions either close to somata or abundant in dendritic projections. In all cases, the NWFET signal amplitudes were from 0.3-3 mV. In contrast to conventional multielectrode array measurements, the small active surface of the NWFET devices, ∼0.06 μm 2 , provides highly localized multiplexed measurements of neuronal activities with demonstrated sub-millisecond temporal resolution and, significantly, better than 30 μm spatial resolution. In addition, multiplexed mapping with 2D NWFET arrays revealed spatially heterogeneous functional connectivity in the olfactory cortex with a resolution surpassing substantially previous electrical recording techniques. Our demonstration of simultaneous high temporal and spatial resolution recording, as well as mapping of functional connectivity, suggest that NWFETs can become a powerful platform for studying neural circuits in the brain.

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Thin-Film Multiple Electrode Probes: Possibilities and Limitations

Cited by 93 publications

References 20 publications

Fabrication and Characterization of Nonplanar Microelectrode Array Circuits for Use in Arthroscopic Diagnosis of Cartilage Diseases

Fabrication and Characterization of Nonplanar Microelectrode Array Circuits for Use in Arthroscopic Diagnosis of Cartilage Diseases

Flexible electrical recording from cells using nanowire transistor arrays

Nanowire transistor arrays for mapping neural circuits in acute brain slices

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