Thicker endometrial linings are associated with better IVF outcomes: a cohort of 6331 women

Holden, E.C.; Dodge, Laura E.; Sneeringer, R.M.; Moragianni, Vasiliki A.; Penzias, Alan S.; Hacker, Michele R.

doi:10.1080/14647273.2017.1334130

Cited by 28 publications

(23 citation statements)

References 12 publications

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“…Previous studies have shown that increased endometrial thickness can significantly improve pregnancy outcomes among women undergoing IVF‐ET . Consistent with those studies, a significantly higher pregnancy rate, implantation rate, and live delivery rate were observed for women whose endometrium was thicker than 7 mm as compared with those whose endometrium was thinner than 7 mm in the present study.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies have shown that increased endometrial thickness can significantly improve pregnancy outcomes among women undergoing IVF-ET. 12,14 Consistent with those studies, a significantly higher pregnancy rate, implantation rate, and live delivery rate were observed for women whose endometrium was thicker than 7 mm as compared with those whose endometrium was thinner than 7 mm in the present study. In addition, the lowest rates of spontaneous abortion were observed for women with an endometrial thickness between 7 and 12 mm, whereas an endometrium thicker than 12 mm showed higher abortion rates.…”

Section: Discussionsupporting

confidence: 91%

“…It remains unclear whether endometrial depth is an important factor for successful implantation in IVF‐ET . Some physicians have regarded endometrial thickness as a predictor of reproductive outcomes in fresh and frozen ET cycles, and a few studies have assessed the relationship between endometrial thickness and pregnancy rates after IVF treatment . Recent studies have shown that operator experience can also affect ET outcomes; however, this conclusion is controversial.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Some physicians have regarded endometrial thickness as a predictor of reproductive outcomes in fresh and frozen ET cycles 11 , and a few studies have assessed the relationship between endometrial thickness and pregnancy rates after IVF treatment. 9,[12][13][14] Recent studies have shown that operator experience can also affect ET outcomes 15 ; however, this conclusion is controversial. In addition, the effect of embryo location on IVF outcomes has not been well studied.…”

mentioning

confidence: 99%

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Ideal embryo transfer position and endometrial thickness in IVF embryo transfer treatment

Wang

Zhu

Sun

et al. 2018

Intl J Gynecology & Obste

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Objective To establish an ideal transfer strategy by investigating the relationships among embryo transfer (ET) depth, endometrial thickness, and subsequent in vitro fertilization treatment clinical pregnancy outcomes. Methods In the present retrospective analysis, data from in vitro fertilization‐ET treatment cycles conducted at a fertility center in Shanghai, China, between October 2014 and March 2015 were analyzed. Women were divided into groups 1–4 according to transfer depth (<10; 10–15, 15–20, and >20 mm, respectively), as measured by air bubbles. Additionally, 391 women were divided into groups A–C according to endometrial thickness (<7, 1–12, and >12 mm, respectively). Clinical pregnancy outcomes were assessed by group. Results Data from 501 cycles were included. Clinical pregnancy and live delivery rates were significantly higher in group 2 (P=0.009 and P=0.002, respectively) and group 3 (P=0.008 and P=0.001, respectively) than in group 4. Among the 394 patients with endometrial thickness data available, clinical pregnancy and live delivery rates were higher in group B (P=0.028 and P=0.015, respectively) and group (P=0.013 and P=0.013, respectively) than in group A. Conclusion Correct transfer depth and endometrial thickness can increase the rates of clinical pregnancy, implantation, and live delivery. Placing the embryos at 10–20 mm from the fundus and at an endometrial thickness of more than 7 mm is recommended for optimal clinical pregnancy outcomes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Ideal embryo transfer position and endometrial thickness in IVF embryo transfer treatment

Wang

Zhu

Sun

et al. 2018

Intl J Gynecology & Obste

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“…The fact that better endometrial thickness could help achieve higher pregnancy rates is understandable and has been made known [11], the hypothesis that vaginal sildenafil could directly increase clinical pregnancy rates, although previously studied has not been well established.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vaginal Sildenafil on in Vitro Fertilization Success Rates in Women With Previous Failed in Vitro Fertilization Attempts

Tehraninejad

Khazei

Ayati

et al. 2018

Asian J Pharm Clin Res

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Objectives: Endometrial thickness of <9 mm is a predictor of in vitro fertilization (IVF) failure, although neither pregnancy rates nor the pregnancy outcomes are dependent on the endometrial thickness alone. The impact that uterine artery blood flow has on endometrial growth is dependent on nitric oxide which concentrations could be altered by halting a cyclic guanosine monophosphate-mediated pathway with a phosphodiesterase type 5 selective inhibitor such as sildenafil. Methods:In this clinical trial, 72 patients aged below 45 years which have had at least two earlier failed IVF attempts were randomly split into two groups each consisting of 36 patients. Both groups were started on a long IVF protocol. The case group was also administered 100 mg vaginal sildenafil suppositories daily, starting on day 3 of menstruation which was continued until human chorionic gonadotropin administration. Endometrial thickness was measured using ultrasonography in both groups plus pregnancy rates were assessed in both groups.

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The relationship and optimal threshold of endometrial thickness with early clinical pregnancy in frozen embryo transfer cycles

Zhang

Wang

et al. 2021

Intl J Gynecology & Obste

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Objective: To investigate the associations of endometrial thickness with pregnancy outcome in frozen embryo transfer (FET) cycles.Methods: A retrospective cohort study was performed looking at 1627 FET cycles from the Reproductive Medicine Center of the study hospital between January 2017 and July 2018. Endometrial ultrasonographic characteristics were recorded on the embryo transfer day in FET cycles.Results: A total of 1627 FET cycles were included. The endometrial thickness was independently associated with clinical pregnancy outcomes after adjusting for potential confounders (odds ratio 1.06; 95% confidence interval [CI] 1.01-1.12). A non-linear relationship was detected between endometrial thickness and pregnancy outcomes, whose point was 10.9 mm. The effect size of the left and right sides of the inflection point were 1.16 (95% CI 1.07-1.25) and 0.89 (95% CI 0.78-1.01), respectively. Subgroup analysis showed that the correlation between endometrial thickness and pregnancy outcome was consistent in all subgroups. Conclusion:The relationship between endometrial thickness and pregnancy outcome was non-linear and there is an inflection point. When endometrial thickness was less than 9.5 mm, it was positively related to clinical pregnancy rate. If it was beyond the inflection point, the pregnancy rate does not increase significantly.

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Thicker endometrial linings are associated with better IVF outcomes: a cohort of 6331 women

Cited by 28 publications

References 12 publications

Ideal embryo transfer position and endometrial thickness in IVF embryo transfer treatment

Ideal embryo transfer position and endometrial thickness in IVF embryo transfer treatment

Effect of Vaginal Sildenafil on in Vitro Fertilization Success Rates in Women With Previous Failed in Vitro Fertilization Attempts

The relationship and optimal threshold of endometrial thickness with early clinical pregnancy in frozen embryo transfer cycles

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