Ideal embryo transfer position and endometrial thickness in <scp>IVF</scp> embryo transfer treatment

Wang, Yao; Zhu, Yanwen; Sun, Yun; Di, Wen; Qiu, Meiting; Kuang, Yanping; Shen, Haoran

doi:10.1002/ijgo.12681

Cited by 19 publications

(22 citation statements)

References 18 publications

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“…Our results are consistent with the ndings of a retrospective cohort study suggesting [20]. However, our study is contradictory to many studies that consider that the best results would be obtained when placing the embryo in the middle of the uterine cavity rather than near the uterus fundus [12][13][14]. It is important to note that we and the retrospective cohort study explored embryo transfer at the blastocyst stage [20], not at the cleavage stage [12][13][14].…”

Section: Discussionsupporting

confidence: 74%

“…There are some advantages to this research. First of all, in most other reports, the distance between air bubble and the uterus fundus was classi ed in 5 mm increments [12][13][14], which may result in errors caused by arti cial grouping. We make up for this de ciency by using the smooth tting curve and threshold effect model.…”

Section: Discussionmentioning

confidence: 99%

“…There have been lots of studies exploring the relationship between embryo transfer position and ART outcome [8][9][10][11]. Most of literature have shown that the location of cleavage embryos cannot be too close to the uterus fundus, nor too far from the uterus fundus, and the middle of the uterine cavity is the best position to place the embryos for optimal ART outcome [12][13][14]. In addition, in the ASRM standard embryo transfer protocol template, a committee suggested that the tip of the catheter should be placed in the upper or center of the uterine cavity (more than 1 cm from the fundus of the uterus) and then released the embryos, which can optimize the pregnancy rate [15].…”

Section: Introduction Embryo Transfer (Et) Is One Of the Most Critical Factors Affecting Assisted Reproductive Technology (Art)mentioning

confidence: 99%

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The effect of air bubble position on ART outcome in frozen-thawed blastocyst transfer

Yang

Sun

et al. 2021

Preprint

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Background So far, only few literatures have studied the relationship between blastocyst transfer position and ART outcomes, and the conclusions are still controversial. Our study is to evaluate the effect of air bubble position on ART outcome and to find the optimal embryo transfer position in frozen-thawed blastocyst transfer. Methods This study included a retrospective cohort analysis of 399 frozen-thawed single blastocyst transfers ultrasound-guided performed between June 1, 2017 and November 30, 2020. All of the women scheduled for frozen-thawed single blastocyst transfers ultrasound-guided. The primary outcome is clinical pregnancy rate and the secondary outcome is live birth rate. Statistical analyses were conducted using One-way Anova, Kruscal Whallis H test, chi-square test and Smooth curve fitting. Results When BFD was less than 19 mm, there was no significant change in clinical pregnancy rate as BFD increased (OR = 0.95, 95% CI: 0.89 to 1.02, P = 0.1373); when BFD was more than 19 mm, the clinical pregnancy rate decreased by 16% for every 1 mm increase in BFD (OR = 0.84, 95% CI: 0.72 to 0.98, P = 0.0363). The effect of BFD on live birth rate were similar to that on clinical pregnancy rate, the inflection point was 19mm, when BFD was more than 19 mm, the live birth rate decreases by 58% for every 1 mm increase in BFD (OR = 0.42, 95% CI: 0.21 to 0.86, P = 0.0174) Conclusions The ideal pregnancy outcome can be achieved within 19mm from uterus fundus after single blastocyst transfer, The clinical pregnancy and live birth at a distance of more 19mm from the uterus fundus have a cliff-like downward trend.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introduction Embryo Transfer (Et) Is One Of the Most Critical Factors Affecting Assisted Reproductive Technology (Art)mentioning

confidence: 99%

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The effect of air bubble position on ART outcome in frozen-thawed blastocyst transfer

Yang

Sun

et al. 2021

Preprint

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“…More recently, this conclusion was confirmed by a retrospective cohort study of 1,512 IVF cycles ( 25 ). Also, an endometrial thickness of more than 7 mm was optimal for clinical pregnancy outcomes ( 26 ). In our study, endometrial thickness was satisfactory for both protocols and did not vary significantly between them.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Number of Euploid Embryos in Preimplantation Genetic Testing Cycles With Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol

Niu

et al. 2020

Front. Endocrinol.

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Studies have shown that early-follicular phase long-acting gonadotropin-releasing hormone (GnRH) agonist long protocol (EFLL), a popular controlled ovarian hyperstimulation protocol widely used in China, leads to higher rates of implantation and clinical pregnancy, as well as lower rates of spontaneous abortion and ectopic pregnancy in patients undergoing in vitro fertilization treatment. However, the impact of EFLL on euploid embryos and its underlying mechanisms remain unclear. To address these gaps of knowledge, we conducted a retrospective comparative study of 310 preimplantation genetic testing (PGT) cycles with a total of 1,541 embryos using the EFLL protocol or midluteal short-acting GnRH agonist long protocol (MLSL). Patients were matched by PGT subtype [aneuploidies (PGT-A) vs. PGT for chromosomal structural rearrangements (PGT-SR)], age (±2 years), and body mass index (±1 kg/m 2 ). For PGT-A, there was no significant difference in the number of euploid embryos (1.80 ± 1.47 for EFLL vs. 1.84 ± 2.03 for MLSL, p > 0.05) or the rate of euploidy (44.6 vs. 36.9%, p > 0.05). For PGT-SR, the number of euploid embryos in the EFLL group was significantly higher than that in the MLSL group (1.76 ± 1.54 vs. 1.21 ± 1.24, p < 0.05). A higher euploidy rate was also observed with the EFLL protocol compared with that obtained in MLSL (31.9 vs. 25.7%), although the difference was not statistically significant ( p > 0.05). Compared with the MLSL protocol, more euploid embryos were achieved when using the EFLL protocol in PGT-SR, demonstrating the value in PGT-SR. To the best of our knowledge, this study is the first one to compare embryonic outcomes between EFLL and MLSL, providing key insights into the clinical application of EFLL in PGT cycles. In the light of the limited sample size of our study, we recommend that these questions be explored using a larger prospective study.

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“…Most studies demonstrated significantly higher pregnancy rate along with the endometrial thickness grew, irrespective of the number or quality of the embryos (22,23). Additionally, an endometrial thickness of more than 7 mm was optimal for clinical pregnancy outcomes (24).…”

Section: A B Cmentioning

confidence: 99%

Prolonged pituitary downregulation with gonadotropin-releasing hormone agonist improves the live-birth rate: a retrospective cohort study comparing 3 different protocols

Ruan¹,

Fang²,

Yang³

et al. 2021

Ann Palliat Med

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Background: The long protocol has been recognized as the gold standard in controlled ovarian hyperstimulation (COH). However, the full dose of gonadotropin-releasing hormone agonist (GnRH-a) under the prolonged protocol has become increasingly popular in China. This study sought to compare pregnancy outcomes among the following 3 groups: a long protocol group, and 2 types of improved prolonged protocol groups.Methods: A retrospective cohort study was conducted of 550 patients undergoing fresh embryo transfer (ET). Patients were treated either with the improved prolonged protocol in the follicular phase (Group 1; n=288) or the mid-luteal phase (Group 2; n=143), or the long protocol (Group 3; n=119). The clinical and laboratory outcomes of the 3 groups were compared. Results:The general characteristics of the women in the 3 groups were comparable. On the day on which gonadotropin (Gn) was first administered and on the day on which human chorionic gonadotropin (hCG) was administered, the luteinizing hormone (LH) levels of patients in both Groups 1 and 2 were lower than those of patients in Group 3. The number of oocytes retrieved, fertilized, and cleaved, and the number of high-quality embryos in the 3 procedures were similar. However, the number of transferred embryos, the rate of blastocyst progression, and the rate of implantation differed. The clinical pregnancy rates (CPRs) were significantly higher in the prolonged protocol groups (62.5% and 61.5%) than the long protocol group (48.7%). Further, statistically significant differences in the live-birth rates (LBRs) (56.9% vs. 57.3% vs. 42.9%) were observed. However, no differences in early abortion rates were found.Conclusions: As a result of pituitary downregulation with GnRH-a, the prolonged groups had better CPRs and LBRs than the long protocol group. The prolonged protocol in the mid-luteal phase was equally effective as that in the early follicular phase in fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles. High LH levels on the day of hCG may be a predictor of adverse clinical outcomes.

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Ideal embryo transfer position and endometrial thickness in IVF embryo transfer treatment

Cited by 19 publications

References 18 publications

The effect of air bubble position on ART outcome in frozen-thawed blastocyst transfer

The effect of air bubble position on ART outcome in frozen-thawed blastocyst transfer

Analysis of the Number of Euploid Embryos in Preimplantation Genetic Testing Cycles With Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol

Prolonged pituitary downregulation with gonadotropin-releasing hormone agonist improves the live-birth rate: a retrospective cohort study comparing 3 different protocols

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