Thermosensitive liposomes: Extravasation and release of contents in tumor microvascular networks

Gaber, Mohamed H.; Wu, Ning; Hong, Keelung; Huang, Shi Kun; Dewhirst, Mark W.; Papahadjopoulos, Demetrios

doi:10.1016/s0360-3016(96)00389-6

Cited by 237 publications

(144 citation statements)

References 34 publications

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“…When tumors exposed to hyperthermia, the tumor blood flow and oxygenation increased, which would improve the delivery of liposomal drugs to tumors (Karino et al, 1988;Horsman & Overgaard, 1997;Kong & Dewhirst, 1999). Furthermore, hyperthermia was able to increase vascular permeability of tumors, thus enhanced the amount of liposome aggregation (Gaber et al, 1996;Kong et al, , 2001. Hyperthermia can induce synergistic effects with chemotherapy (Issels et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Wang¹,

Zhang²,

Yang³

et al. 2015

Drug Delivery

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To increase the anti-tumor activity of paclitaxel (PTX), novel temperature-sensitive liposomes loading paclitaxel (PTX-TSL) were developed. In vitro, characteristics of PTX-TSL were evaluated. The mean particle diameter was about 100 nm, and the entrapment efficiency was larger than 95%. The phase-transition temperature of PTX-TSL determined by differential scanning calorimetry was about 42C. The result of in vitro drug release from PTX-TSL illustrated that release rate at 37 C was obviously lower than that at 42 C. Stability data indicated that the liposome was physically and chemically stable for at least 3 months at À20 C. In vivo study, after three injections with hyperthermia in the xenograft lung tumor model, PTX-TSL showed distinguished tumor growth suppression, compared with non-temperature-sensitive liposome and free drug. The results of intratumoral drug concentration indicated that PTX-TSL combined with hyperthermia delivered more paxlitaxel into the tumor location than the other two paxlitaxel formulations. In summary, PTX-TSL combined with hyperthermia significantly inhibited tumor growth, due to the increased targeting efficiency of PTX to tumor tissues. Such approach may enhance the delivery efficiency of chemotherapeutics into solid tumors.

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Wang¹,

Zhang²,

Yang³

et al. 2015

Drug Delivery

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“…The combination of interstitial hyperthermia with external radiation has also been tried for gliomas [111]. In one study, radiofrequency hyperthermia was also applied extra-cranially [112].…”

Section: Introduction and Interpretation Of A Relative "Old Method" Imentioning

confidence: 99%

What is on the Horizon for Hyperthermic Cancer Therapy?

GyP¹,

Dy²,

Hegyi³

2017

J Tradi Med Clin Natur

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“…As tissue temperature rises, one of the first physiological reactions is an in- crease in tumor blood flow, causing an additional delivery of a drug (6). Furthermore, an increased tumor microvessel pore size has been noticed in some studies during heating, resulting in an increased extravasation of drug delivery vehicles from tumor vessels (7,8). This effect is shown in Fig.…”

Section: Heat Generationmentioning

confidence: 99%

The role of ultrasound and magnetic resonance in local drug delivery

Deckers

Rome

Moonen

2008

Magnetic Resonance Imaging

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Local drug delivery has recently attracted much attention since it represents a strategy to increase the drug concentration at the target location and decrease systemic toxicity effects. Ultrasound can be used in different ways to trigger regional drug delivery. It can cause the local drug release from a carrier vehicle and the local increase of cell membrane permeability either by a mechanical action or by a temperature increase. Ultrasound contrast agents may enhance these effects by means of cavitation. Ultrasound can be focused deep inside the body into a small region with dimensions on the order of 1 mm. Several types of drug microcarriers have been proposed, from nano-to micrometer sized particles. The objective of real-time imaging of local drug delivery is to assure that the delivery takes place in the target region, that the drug concentration and the resulting physiological reaction are sufficient, and to intervene if necessary. Ultrasound and nuclear imaging techniques play an important role. MRI is rather insensitive but allows precise targeting of (focused) ultrasound, can provide real-time temperature maps, and gives access to a variety of imaging biomarkers that may be used to assess drug action. Examples from recent articles illustrate the potential of the principles of ultrasound-triggered local drug delivery.

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Thermosensitive liposomes: Extravasation and release of contents in tumor microvascular networks

Cited by 237 publications

References 34 publications

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

What is on the Horizon for Hyperthermic Cancer Therapy?

The role of ultrasound and magnetic resonance in local drug delivery

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