What is on the Horizon for Hyperthermic Cancer Therapy?

GyP, Szigeti; Dy, Lee; Hegyi, Gabriella

doi:10.4172/2573-4555.1000217

Cited by 3 publications

(2 citation statements)

References 105 publications

(112 reference statements)

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“…HT techniques typically fall into three categories: whole-body, local, and regional (Van Der Zee 2002). Whole-body HT is typically used to treat metastatic disease by heating the entire body of patients using physical modalities, such as heated air, heated water, infrared chamber, heated blankets, and extracorporeal blood-warming (Gyp et al 2017; Short and Turner 1980). Local HT is generally used to treat solid, localized disease at or near the surface of the skin or natural body orifices (Datta et al 2015; Gao et al 2016).…”

Section: Ht Techniquesmentioning

confidence: 99%

Ultrasound Hyperthermia Technology for Radiosensitization

Zhu

Altman

Laszlo

et al. 2019

Ultrasound in Medicine & Biology

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Hyperthermia therapy (HT) raises tissue temperature to 40–45°C for up to 60 minutes. Hyperthermia is one of the most potent sensitizers of radiation therapy (RT). Ultrasound-mediated HT for radiosensitization has been used clinically since the 1960s. Recently, magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU), which has been approved by the United States Food and Drug Administration for thermal ablation therapy, has been adapted for HT. With emerging clinical trials using MRgHIFU HT for radiosensitization, there is a pressing need to review the ultrasound HT technology. The objective of this review is to overview existing HT technology, summarize available ultrasound HT devices, evaluate clinical studies combining ultrasound HT with RT, and discuss challenges and future directions.

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Section: Ht Techniquesmentioning

confidence: 99%

Ultrasound Hyperthermia Technology for Radiosensitization

Zhu

Altman

Laszlo

et al. 2019

Ultrasound in Medicine & Biology

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“…They produce bifocal focusing profiles with equal intensity focus at distances related to the M-bonacci sequence ratio. The application of ultrasound focusing techniques is a topic of great interest in both photoacoustic imaging [24,25] and therapeutic applications [26,27,28,29]. In the latter, dual focusing profiles can be used to either treat two isolated regions simultaneously or target extensive areas with higher efficiency [30,31].…”

Section: Introductionmentioning

confidence: 99%

M-Bonacci Zone Plates for Ultrasound Focusing

Pérez-López¹,

Fuster²,

Candelas³

2019

Sensors

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In this work, we present a thorough analysis on M-bonacci zone plates for ultrasound focusing applications. These planar lenses are capable of providing bifocal focusing profiles with equal intensity in both foci and become very appealing for a wide range of scenarios including medical and industrial applications. We show that in high-wavelength domains, such as acoustics or microwaves, the separation between both foci can be finely adjusted at the expense of slightly increasing the distortion of the focusing profile, and we introduce a design parameter to deal with this issue and simplify the design process of these lenses. Experimental measurements are in good agreement with numerical simulations and demonstrate the potential of M-bonacci lenses in ultrasound focusing applications.

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