Thermodynamics of solubility of isatin in (PEG 400+water) mixed solvent systems at T=(298.15 to 338.15)K

Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics

“…Therefore, such physicochemical properties of ECT in cosolvent-water mixtures should be evaluated properly in order to obtain its complete physicochemical profile [6,7]. "Polyethylene glycol-400 (PEG-400)" has been reported as an efficient cosolvent in solubilization of drugs in aqueous media and it is miscible with water in all proportions [9][10][11]. The potential of PEG-400 has been studied extensively in solubility enhancement of various drugs [9][10][11][12][13][14][15][16][17][18].…”

“…"Polyethylene glycol-400 (PEG-400)" has been reported as an efficient cosolvent in solubilization of drugs in aqueous media and it is miscible with water in all proportions [9][10][11]. The potential of PEG-400 has been studied extensively in solubility enhancement of various drugs [9][10][11][12][13][14][15][16][17][18]. Several formulation approaches including "3D printed controlled release tablets [4], film coated tablets [19], rapidly disintegrating vaginal tablets [20], immediate release tablets [21], vaginal gels [22], liposomal gels [23], microparticulate drug delivery system [24], nanosuspensions [25,26] and polymeric nanoparticles [5,27,28]" were reported to improve antiviral therapy and pharmacokinetic profile of ECT.…”

Solubility and solution thermodynamics of meloxicam in polyethylene glycol 400+water mixtures

“…Thus, enthalpy-driving was found for transfer processes in all the mixtures evaluated. Finally, it is noteworthy that the reported solubility values in this research as well as the other recently published by other research groups [22][23][24][25][26]44,45] expand the pharmaceutical database [3] useful for drug delivery systems design involving aqueous PEG 400 mixtures.…”

“…It is important to note that PEG 400 is miscible with water in all the range of compositions and it is widely used to develop liquid medicines due to its high solubilizing power [19]. Otherwise, it is noteworthy that several thermodynamic studies about the solubility of drugs in aqueous PEG 400 mixtures have been recently reported in the literature [20][21][22][23][24][25][26] which demonstrate the practical usefulness of them in the pharmaceutical field. Even more, PEG 400 (1) + water (2) co-solvent mixtures have been thermodynamically characterized from a volumetric point of view at several temperatures [27] and have also been challenged by using the Jouyban-Acree model to correlate the equilibrium solubility of several other drugs as a function of mixtures composition and temperature [28].…”

Thermodynamics of solubility of ibrutinib in ethanol+water cosolvent mixtures at different temperatures

“…The values of standard enthalpies (Δ sol H 0 ) for dissolution of crystalline IBR in various ethanol + water cosolvent mixtures were determined by Van't Hoff analysis [20,21]. The Δ sol H 0 values were calculated at mean harmonic temperature (T hm ) of 308.91 K using Eq.…”