Thermodynamics of solubility of ibrutinib in ethanol+water cosolvent mixtures at different temperatures

Bioavailability enhancement and pharmacokinetic profile of an anticancer drug ibrutinib by self-nanoemulsifying drug delivery system

“…The sample mixtures were shaken continuously in a biological shaker (Julabo, MA) at 7 × g and 37 ± 0.5 °C for 72 h to get the equilibrium . After 72 h, all the samples were taken out from the shaker, and the supernatants subjected for analysis of IBR content spectrophotometrically at 260 nm …”

“…About 3 ml of samples from each formulation were withdrawn at 0, 0.5, 1, 2, 4, 6, 8, 12, 24, 36 and 48 h and same amount of IBR‐free fresh dissolution media was replaced every time. The IBR content in each dissolution sample was quantified spectrophotometrically at the wavelength of 260 nm as reported in literature …”

“…The most recently, cosolvency approach had been investigated to enhance solubilization of crystalline IBR in an aqueous media. In cosolvency approach, Carbitol and ethanol were used as effective cosolvents for solubility enhancement of IBR . To the best of our knowledge, SNEDDS approach for bioavailability enhancement of IBR had not yet investigated in literature.…”

Correlation and prediction of solubility of hydrogen in alkenes and its dissolution properties

“…The thermodynamic parameters for dissolution of hydrogen in various alkenes were expressed (or measured) in terms of dissolution enthalpy (ΔH • ) , Gibbs free energy (ΔG • ) , and dissolution entropy (ΔS • ) . The ΔH • values for dissolution behavior of hydrogen in each alkene were determined using Van't Hoff equation [23][24][25][26]. The ΔH • was calculated using Eq.…”

“…Recently, Liu et al [11] investigated the thermodynamic properties of the dissolution of various types of gases, including hydrogen, in the ionic liquid [emim] [Tf2N] using the Van't Hoff equation. Also Shakeel et al [23][24][25][26] using the Van't Hoff equation, calculated the thermodynamic properties of dissolved solids in liquids.…”