Solubility and solution thermodynamics of meloxicam in polyethylene glycol 400+water mixtures

Solubility and solvation behavior of N′-(1-(N-(methyl) benzylaminomethyl)-2-oxoindolin-3-ylidene)-2-(benzyloxy) benzohydrazide in (PEG 400+water) mixtures

“…This behavior was similar to the solvation behavior of other practically insoluble drugs such as meloxicam, tenoxicam and indomethacin etc. [12,27,28].…”

“…It had great potential in solubilization and stabilization of poorly soluble therapeutic compounds [9][10][11]. Because of its great solubilization power, it is used commonly in dosage form design of poorly water soluble therapeutic compounds [10,12]. The solubility data and solvation behavior of hydrazide derivatives in aqueous-cosolvent mixtures are poorly reported in literature.…”

Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics

“…Therefore, such physicochemical properties of ECT in cosolvent-water mixtures should be evaluated properly in order to obtain its complete physicochemical profile [6,7]. "Polyethylene glycol-400 (PEG-400)" has been reported as an efficient cosolvent in solubilization of drugs in aqueous media and it is miscible with water in all proportions [9][10][11]. The potential of PEG-400 has been studied extensively in solubility enhancement of various drugs [9][10][11][12][13][14][15][16][17][18].…”

“…"Polyethylene glycol-400 (PEG-400)" has been reported as an efficient cosolvent in solubilization of drugs in aqueous media and it is miscible with water in all proportions [9][10][11]. The potential of PEG-400 has been studied extensively in solubility enhancement of various drugs [9][10][11][12][13][14][15][16][17][18]. Several formulation approaches including "3D printed controlled release tablets [4], film coated tablets [19], rapidly disintegrating vaginal tablets [20], immediate release tablets [21], vaginal gels [22], liposomal gels [23], microparticulate drug delivery system [24], nanosuspensions [25,26] and polymeric nanoparticles [5,27,28]" were reported to improve antiviral therapy and pharmacokinetic profile of ECT.…”

Predicting Solubility of Small Molecules in Macromolecular Compounds for Nanomedicine Application from Atomistic Simulations

“…However, strongly hydrogen‐bonded solutions such as alcohol–water mixtures [ 29 ] are known to show negative entropy of mixing due to cluster formation in solution. [ 30 ] This applies also to aqueous solutions of poly(ethylene oxide) [ 31 ] (PEO) and PEO‐drug mixtures [ 32 ] showing pronounced hydrogen bonding. Therefore, more sophisticated equation of state (EOS) theories are required for reliable predictions of the thermodynamic compatibility between the polymers and the active substances.…”