Thermodynamic and kinetic characterization of pH-dependent interactions between bovine serum albumin and ibuprofen in 2D and 3D systems

Modelling and Characterization of the Sorption of Kynurenic Acid on Protein Surfaces

“…These values show a good agreement with the suggested size of a human serum albumin protein in solution [18]. Under same conditions for BSA a m = 128.4 nm 2 was determined [12]. As presented in Fig.…”

“…Chemical or physical adsorption onto the gold surface changes the refractive index of the dielectric, thereby the propagation constant of the surface plasmon is also changed [6]. Still, several research groups have published their results in the topic of characterization of different biomolecule interactions [7][8][9][10], but only a few articles offer deeper information on the temperature-dependent interactions between peptides or proteins and potential drug molecules by using SPR [11,12]. The objective of the present work was to provide complementary data on the interactions between serum albumins and KYNA by using only SPR experiments.…”

The Theoretical Concept of Polarization Reflectometric Interference Spectroscopy (PRIFS): An Optical Method to Monitor Molecule Adsorption and Nanoparticle Adhesion on the Surface of Thin Films

“…Several methods are known in the literature to detect the presence of any adsorbate: electric (resistive [1][2][3] and capacitive [4,5]) techniques operate mainly in the gas phase as volatile organic compound (VOC) sensors [6,7], while optical methods can be used both in gas and aqueous medium, mainly as biosensors. The latter group can be divided into plasmonic [8][9][10], waveguide [11,12] and reflectometric devices.…”

Cross-linked and hydrophobized hyaluronic acid-based controlled drug release systems

“…Several biodegradable macromolecules such as polyesters, proteins, polysaccharides, polyelectrolytes, lipids etc. (Benkő et al, 2015;Csapó et al, 2016;Danhier et al, 2012;Kumari et al, 2010;Padilla et al, 2002;Palumbo et al, 2006;Pasqui et al, 2012), or inorganic materials (layer double hydroxides (LDH), clays, mesoporous silica etc. (Deák et al, 2018;Varga, Benko, Sebok, Bohus, et al, 2014) are used as drug carriers in order to achieve a targeted drug delivery system and also a controlled drug release process.…”

“…Generally, albumin proteins, biocompatible polymers, liposomes, or solid lipid NPs have been utilized for encapsulation of non-steroidal anti-inflammatory drugs (NSAID) such as ibuprofen, meloxicam etc. (Benkő et al, 2015;Csapó et al, 2016;. Ketoprofen (KP) also belongs to NSAID and is widely used to treat postoperative pain, including patients after a gastric resection.…”