Cross-linked and hydrophobized hyaluronic acid-based controlled drug release systems

Abstract

This work demonstrates the preparation, structural characterization, and the kinetics of the drug release of hyaluronic acid (HyA)-based colloidal drug delivery systems which contain hydrophobic ketoprofen (KP) as model molecule. Because of the highly hydrophilic character of HyA the cross-linked derivatives at different cross-linking ratio have been synthesized. The hydrophobized variants of HyA have also been produced by modifying the polymer chains with cetyltrimethylammonium bromide (CTAB) at various HyA/CTAB ratios. Due to modifications the coherent structure of HyA changes into an incoherent colloidal system that were verified by rheological investigations. Nearly 70% of the encapsulated KP dissolve from the totally cross-linked HyA carrier but the release rate of KP is about 20% (after 8 h) from the CTAB-modified colloidal system at HyA monomer/CTAB 1:0.8 mass ratio. It has been verified that the modified HyA may be a potential candidate for controlled drug release of hydrophobic KP molecules.

The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

“…Recently, the development of organic-based nanocarriers has been the focus of extensive research thanks to their outstanding biocompatible and biodegradable properties [ 1 ]. Besides biocompatible polymers [ 6 , 7 , 8 , 9 , 10 ], serum albumins [ 11 , 12 , 13 ] can be also used to synthesize several biocompatible drug delivery systems applying the layer-by-layer (LbL) preparation technique. The liposomes (LIPs) are also potential carriers due to the amphiphilic properties of the phospholipid building blocks [ 14 ].…”

Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release

“…Utilization of drug delivery systems can increase and prolong the efficiency of the active drugs. Due to the good biocompatibility and structural properties, several materials such as proteins and mostly biodegradable polymers, e.g., chitosan, alginate, hyaluronic acid, poly(lactide) or poly(lactic acid) (PLA), polycaprolactone (PCL), poly(trimetilene-carbonate) (PTMC), etc., have been widely used as potential carriers of the nanosized drug delivery systems [4,5,6,7,8,9,10,11,12]. Many types of PLA copolymers, such as poly(lactide- co -glycolide) (PLGA), polylactide-poly(ethylene glycol) (PLA-PEG), poly(caprolactone-ethylene glycol-lactide) (PCELA), etc., are also well-known as drug carriers [13,14,15,16,17].…”

The effect of synthesis conditions and tunable hydrophilicity on the drug encapsulation capability of PLA and PLGA nanoparticles

“…Three types of drugs as model molecules were tested in PLGA carriers like ketoprofen (KP), which is a non-steroidal anti-inflammatory drug (NSAID) mainly used in treatment of acute pain and chronic arthritis [13]. The more hydrophobic α-Tocopherol is an organic compound of vitamin E activity thus can be used in the prevention and treatment of some chronic, agerelated diseases [14].…”