Modelling and Characterization of the Sorption of Kynurenic Acid on Protein Surfaces

Juhász, Ádám; Csapó, Edit; Vécsei, László; Dékány, Imre

doi:10.3311/ppch.10185

Cited by 6 publications

(4 citation statements)

References 25 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides the calculated values of enthalpy by nonlinear parameter estimation, the uncertainty of the thermodynamic data is also important. To calculate the standard deviations of the fitting parameters, a weighted resampling ''jackknife'' procedure was used [38,39]. Nonlinear parameter estimation-based fitting of the experimental data pairs (four different ln cmc vs. T data pairs) was repeated four times using different starting conditions.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Thermodynamic Characterization of Temperature‐ and Composition‐Dependent Mixed Micelle Formation in Aqueous Medium

Juhász

Tabajdi

Dékány

et al. 2017

J Surfact & Detergents

Self Cite

View full text Add to dashboard Cite

This article provides a detailed description of micellization of a binary nonionic surfactant system (Lutensol AP9 and AP20) at different compositions and temperatures in an aqueous medium. Critical micelle concentrations of the individual components (CMCi) and the mixed surfactants (CMCm) were determined via surface tension measurements in the temperature range of 288.15–318.15 K. On the basis of the magnitude and temperature dependence of CMC values, changes in the Gibbs energy (ΔmicG), enthalpy (ΔmicH), and entropy (ΔmicS) of micellization were evaluated. At 288.15 K the thermodynamic parameters were confirmed by isotherm titration calorimetry (ITC). Regular solution theory (RST) was used to estimate the compositions of the mixed micelles (XM) and molecular interaction parameters (βM) for all molar ratios and temperatures. The results of evaluations based on the closed association model and RST were compared.

show abstract

Section: Resultsmentioning

confidence: 99%

“…To calculate the standard deviations of the fitting parameters, a weighted resampling "jackknife" procedure was used [38,39].…”

Section: Resultsmentioning

confidence: 99%

Thermodynamic Characterization of Temperature‐ and Composition‐Dependent Mixed Micelle Formation in Aqueous Medium

Juhász

Tabajdi

Dékány

et al. 2017

J Surfact & Detergents

Self Cite

View full text Add to dashboard Cite

show abstract

“…Az említett idegtudományi kutatócsoporttal folytatott kinurénsav központú kutatás során az említett potenciális hatóanyag szorpciós izotermáinak meghatározását végeztük el az AMPA (alfa-amino-3-hidroxi-5-metil-4-isoxazolpropionsav) receptor GluR 1 (glutamát receptor) alegységet modellezõ peptid fragmensekkel funkcionalizált 11 12,13 125. évfolyam, 1. szám, 2019.…”

Section: áBra Az Spr Mérési Elvének Bemutatása (A) Illetve a Regisztunclassified

Nanoszerkezetű anyagok alkalmazása a szenzor fejlesztés, az olajipar, a gyógyszerkutatás és a heterogén katalízis területén

Csapó¹,

Sebők²,

Janovák³

et al. 2019

MKF

Self Cite

View full text Add to dashboard Cite

“…The detailed description of the different kinetic models is summarized in Supplemetary. To determine the value of the kinetic constants and other parameters of the applied release kinetic models, the sum of the square of differences between the measured and predicted concentration values have been minimalized using a spreadsheet based computer application for nonlinear parameter estimation (Juhász et al, 2016;Juhász, Csapó, Vécsei, & Dékány, 2017). HyA/100% particles.…”

Section: In Vitro Drug Release Experimentsmentioning

confidence: 99%

Cross-linked and hydrophobized hyaluronic acid-based controlled drug release systems

Csapó

Szokolai

Juhász

et al. 2018

Carbohydrate Polymers

Self Cite

View full text Add to dashboard Cite

This work demonstrates the preparation, structural characterization, and the kinetics of the drug release of hyaluronic acid (HyA)-based colloidal drug delivery systems which contain hydrophobic ketoprofen (KP) as model molecule. Because of the highly hydrophilic character of HyA the cross-linked derivatives at different cross-linking ratio have been synthesized. The hydrophobized variants of HyA have also been produced by modifying the polymer chains with cetyltrimethylammonium bromide (CTAB) at various HyA/CTAB ratios. Due to modifications the coherent structure of HyA changes into an incoherent colloidal system that were verified by rheological investigations. Nearly 70% of the encapsulated KP dissolve from the totally cross-linked HyA carrier but the release rate of KP is about 20% (after 8 h) from the CTAB-modified colloidal system at HyA monomer/CTAB 1:0.8 mass ratio. It has been verified that the modified HyA may be a potential candidate for controlled drug release of hydrophobic KP molecules.

show abstract

Modelling and Characterization of the Sorption of Kynurenic Acid on Protein Surfaces

Abstract: This paper presents a surface plasmon resonance (SPR)

Cited by 6 publications

References 25 publications

Thermodynamic Characterization of Temperature‐ and Composition‐Dependent Mixed Micelle Formation in Aqueous Medium

Thermodynamic Characterization of Temperature‐ and Composition‐Dependent Mixed Micelle Formation in Aqueous Medium

Nanoszerkezetű anyagok alkalmazása a szenzor fejlesztés, az olajipar, a gyógyszerkutatás és a heterogén katalízis területén

Cross-linked and hydrophobized hyaluronic acid-based controlled drug release systems

Contact Info

Product

Resources

About