Thermo-reversible injectable gel based on enzymatically-chopped low molecular weight methylcellulose for exenatide and FGF 21 delivery to treat types 1 and 2 diabetes

Kim, Jang Kyoung; Yoo, Changhun; Hoon, Yong; Kim, Yong Hee

doi:10.1016/j.jconrel.2014.09.014

Cited by 28 publications

(11 citation statements)

References 30 publications

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“…Temperature and pH can affect the activity of encapsulated compounds during the process of DMN fabrication 27 . Therefore, we evaluated the effects of thermal conditions on the activity of Ex-4 at 4, 25, 60, and 80 °C for up to 90 min (Fig.…”

Section: Resultsmentioning

confidence: 99%

Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes

Lahiji

Jang

Huh

et al. 2018

Sci Rep

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Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally invasive manner. Most studies indicate that encapsulating therapeutics in DMNs is an efficacious approach; however, the importance of evaluating the activity of encapsulated compounds, during the fabrication process, has not been examined in detail. Conducting an analysis of thermal, chemical, and physical stress factors, including temperature, pH, and the interaction of the polymer and therapeutics mixture during preparation, is essential for retaining the activity of encapsulated therapeutics during and after fabrication. Here, we optimised the thermal, chemical, and physical parameters for the fabrication of exendin-4 (Ex-4)-encapsulated DMNs (Ex-4 DMNs). Ex-4, a peptide agonist of glucagon-like peptide (GLP) receptor, is used for glycaemic control in patients with type 2 diabetes. Our findings indicate that optimising the parameters involved in DMN fabrication retained the activity of Ex-4 by up to 98.3 ± 1.5%. Ex-4 DMNs reduced the bloodglucose level in diabetic mice with efficiency similar to that of a subcutaneous injection. We believe that this study paves way for the commercialisation of an efficient and minimally invasive treatment for patients with type 2 diabetes.

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Section: Resultsmentioning

confidence: 99%

Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes

Lahiji

Jang

Huh

et al. 2018

Sci Rep

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“…The samples were tested under angular frequency sweep mode with a fixed shear strain of 1%. 16,26,27…”

Section: Gelation Properties Of Composite Solutionsmentioning

confidence: 99%

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Dong¹,

Zhuang²,

Hao³

et al. 2020

IJN

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Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel is injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play important roles in promoting wound repair. Methods: The purpose of this research was to prepare a novel thermo-sensitive hydrogelpoly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) (PP) loaded with superoxide dismutase (SOD) to improve the effect for trauma treatment. The micromorphology of the hydrogel was observed by scanning electron microscope and the physical properties were measured. The biocompatibility of hydrogel was evaluated by MTT experiment, and the effect of hydrogel on skin wound healing was evaluated by in vivo histological staining. Results: Gelling behavior and differential scanning calorimeter outcomes showed that the PP hydrogels possessed thermo-sensitivity at physiological temperature and the phase transformation temperature was 28.2°C. The high swelling rate and good water retention were conducive to wound healing. The activity of SOD in vitro was up to 85% at 10 h, which was advantageous to eliminate the superoxide anion. MTT assay revealed that this hydrogel possessed good biocompatibility. Dressings of PP loaded with SOD (SOD-PP) had a higher wound closure rate than other treatments in vivo in diabetic rat model. Discussion: The SOD-PP thermo-sensitive hydrogels can effectively promote wound healing and have good application prospects for wound repair.

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“…These drugs were slowly released from the gel with no initial burst, and resulted in a reduction in blood glucose levels for one week in type 1 diabetic mice (exenatide LMwMC), and for 10 days in type 2 diabetic mice (FGF‐21 drug depot). [ 98 ]…”

Section: Bioresponsive Multitasking Hydrogels In the New Era Of Biome...mentioning

confidence: 99%

Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine

Niazi

Alizadeh

Zarebkohan

et al. 2021

Adv Funct Materials

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Advanced forms of hydrogels have many inherently desirable properties and can be designed with different structures and functions. In particular, bioresponsive multifunctional hydrogels can carry out sophisticated biological functions. These include in situ single-cell approaches, capturing, analysis, and release of living cells, biomimetics of cell, tissue, and tumor-specific niches. They can allow in vivo cell manipulation and act as novel drug delivery systems, allowing diagnostic, therapeutic, vaccination, and immunotherapy methods. In the present review of multitasking hydrogels, new approaches and devices classified into point-of-care testing (POCT), microarrays, single-cell/rare cell approaches, artificial membranes, biomimetic modeling systems, nanodoctors, and microneedle patches are summarized. The potentials and application of each format are critically discussed, and some limitations are highlighted. Finally, how hydrogels can enable an "all-in-one platform" to play a key role in cancer therapy, regenerative medicine, and the treatment of inflammatory, degenerative, genetic, and metabolic diseases is being looked forward to.

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Thermo-reversible injectable gel based on enzymatically-chopped low molecular weight methylcellulose for exenatide and FGF 21 delivery to treat types 1 and 2 diabetes

Cited by 28 publications

References 30 publications

Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes

Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine

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