Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine

Abstract

Advanced forms of hydrogels have many inherently desirable properties and can be designed with different structures and functions. In particular, bioresponsive multifunctional hydrogels can carry out sophisticated biological functions. These include in situ single-cell approaches, capturing, analysis, and release of living cells, biomimetics of cell, tissue, and tumor-specific niches. They can allow in vivo cell manipulation and act as novel drug delivery systems, allowing diagnostic, therapeutic, vaccination, and immunotherapy methods. In the present review of multitasking hydrogels, new approaches and devices classified into point-of-care testing (POCT), microarrays, single-cell/rare cell approaches, artificial membranes, biomimetic modeling systems, nanodoctors, and microneedle patches are summarized. The potentials and application of each format are critically discussed, and some limitations are highlighted. Finally, how hydrogels can enable an "all-in-one platform" to play a key role in cancer therapy, regenerative medicine, and the treatment of inflammatory, degenerative, genetic, and metabolic diseases is being looked forward to.

Recent advances in targeted drug delivery systems for resistant colorectal cancer

“…Hydrogel provide a substrate for entrapping different materials with astonishing features namely controlled degradation, sustained cargo release, less toxicity, functionality, and also high capacity of loading drug with transient state formation (sol–gel transition) [ 114 ]. Generally, different classification for hydrogels can be provided, for instance, bioresponsive hydrogels [ 14 ], bioinspired hydrogels [ 115 ], as well as static, dynamic hydrogels, and hybrid ones [ 116 ]. Also, different types of hydrogel administration including peroral, rectal, vaginal, ocular, transdermal and implants as same as several therapeutic area like ophthalmic, oral, intestinal, cardiac illness and cancer are also exist [ 117 ].…”

“…Nano targeted drug delivery systems (NTDDs) have become popular among researchers to manage cancers [ 13 ]. Different strategies can be used to design bioresponsive nanoparticles (NPs) [ 14 ] including pH-dependent [ 15 ], thermal [ 16 ], enzyme [ 17 ], redox sensitive [ 18 ], ligand-based [ 16 ] and magnetically driven systems [ 19 ]. In addition, there are also different nanovectors such as liposome, dendrimers, carbon nanotubes, PEG polymers and others that deliver therapeutic agents to tumor sites [ 20 , 21 ].…”

Smart Internal Bio‐Glues

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Smart bio-glues for wound healing, tissue adhesion, and other biomedical applications are particularly interesting by exhibiting stimuli-responsive features compared with conventional samples. [14][15][16][17][18][19][20] For example, light-responsive bio-glues with contact-free, spatiotemporal regulation, rigorous tailor, remote control, and other unique advantages have been DOI: 10.1002/advs.202203587 widely used in wound healing, [21] adhesive hemostasis, [22] and tissue adhesion. [23][24][25] Several kinds of smart polymers would undergo a sol-gel transition process upon irradiation by UV or visible light, which could achieve rapid hemostasis, biomimetic tissue engineering, and tissue sealing.…”

H3 (Hydrogel‐Based, High‐Sensitivity, Hybrid) Plasmonic Transducers for Biomolecular Interactions Monitoring

“…Point-of-care (POC) and wearable sensing devices based on optical transduction are still in their early stages, mainly due to the very accurate fabrication procedures required and the lower mechanical robustness compared to their electrical/electrochemical analogs. [1,2] Nevertheless, new hybrid plasmonic devices based on low-cost, polymeric materials have been recently gaining ground. [3,4] Polymers ensure high flexibility, adaptability to nonplanar surfaces, and ease of integration within (PEF), exploit the LSPR to increase the signal intensity of fluorescent dyes, depending on the spectral overlapping between plasmonic absorption and fluorescent dye extinction/emission and their separation distance.…”