Smart Internal Bio‐Glues

Zhang, Hengjie; Zhang, Jianhua; Xu, Peng; Zhan, Li; Bai, Wanjie; Wang, Tianyou; Gu, Zhipeng; Li, Yiwen

doi:10.1002/advs.202203587

Cited by 25 publications

(18 citation statements)

References 59 publications

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“…The healing state of both Csponge and Ssponge-2-treated livers was further evaluated by H&E and Masson staining (Figure 6d,e). [3] Csponge-treated livers exhibited a more extensive abnormal area when compared with the Ssponge-treated ones in the H&E micrographs (Figure 6d; and Figure S7, Supporting Information). Host cell infiltration is the primary step for endogenous tissue regeneration.…”

Section: Resultsmentioning

confidence: 98%

Succinic Ester‐Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration

Zhu

Zhang

Duan

et al. 2022

Adv Healthcare Materials

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Shape memory sponges are very promising in stopping the bleeding from noncompressible and narrow entrance wounds. However, few shape memory sponges have fast degradable properties in order to not hinder tissue healing. In this work, based on cryopolymerization, a succinic ester‐based sponge (Ssponge) is fabricated using gelatin and bi‐polyethylene glycol‐succinimidyl succinate (Bi‐PEG‐SS). Compared with the commercially available gelatin sponge (Csponge), Ssponge possesses better water/blood absorption ability and higher mechanical pressure over the surrounding tissues. Moreover, in the models of massive liver hemorrhage after transection and noncompressive liver wounds by penetration, Ssponge exhibits a better hemostasis performance than Csponge. Furthermore, in a liver regeneration model, Ssponge‐treated livers shows higher regeneration speed compared with Csponge, including a lower injury score, more cavity‐like tissues, less fibrosis and enhanced tissue regeneration. Overall, it is shown that Ssponge, with a fast degradation behavior, is not only highly efficient in stopping bleeding but also not detrimental for tissue healing, possessing promising clinical translational potential.

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Section: Resultsmentioning

confidence: 98%

Succinic Ester‐Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration

Zhu

Zhang

Duan

et al. 2022

Adv Healthcare Materials

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“…These hydrogel materials exhibit excellent properties, including sensitive responsiveness, desirable catalytic activity, antioxidative properties, and excellent photothermal performances, which provide emerging therapies for tissue repair. [205][206][207] Among them, photo-thermo coupled responsive hydrogels are very attractive by combining the advantages of thermo-responsiveness and the photothermal effect. First, thermo-responsive hydrogels with inherent injectable or sprayable characteristics are very promising due to the fact that they can completely fill irregular wounds, avoiding secondary injury during treatment.…”

Section: Wound Healing and Bacterial Killingmentioning

confidence: 99%

Thermo‐Responsive Hydrogels Coupled with Photothermal Agents for Biomedical Applications

Qian

Meng

et al. 2023

Macromolecular Bioscience

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Intelligent hydrogels are materials with abilities to change their chemical nature or physical structure in response to external stimuli showing promising potential in multitudinous applications. Especially, photo‐thermo coupled responsive hydrogels that are prepared by encapsulating photothermal agents into thermo‐responsive hydrogel matrix exhibit more attractive advantages in biomedical applications owing to their spatiotemporal control and precise therapy. This work summarizes the latest progress of the photo‐thermo coupled responsive hydrogel in biomedical applications. Three major elements of the photo‐thermo coupled responsive hydrogel, i.e., thermo‐responsive hydrogel matrix, photothermal agents, and construction methods are introduced. Furthermore, the recent developments of these hydrogels for biomedical applications are described with some selected examples. Finally, the challenges and future perspectives for photo‐thermo coupled responsive hydrogels are outlined.This article is protected by copyright. All rights reserved

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“…Considering the unique molecular structural features of BIPY (i.e., aldehyde group for Schiff base reaction and bipyridine unit for N-metal ion coordination interaction, respectively), [35][36][37][38][39][40] it was anticipated that BIPY could act as a robust and bifunctional adaptor to assemble with different kinds of aminoglycosides and metal ions to fabricate all-small-molecule dynamic metallogels with multiple stimuli responsiveness. Besides, the resulting metallogels also demonstrated many other promising features, including conductivity, antibacterial properties, tunable mechanical properties and controlled drug release.…”

Section: Introductionmentioning

confidence: 99%