Thermal Stability and Kinetic Studies of Cobalt (Ii), Nickel (Ii), Copper (Ii), Cadmium (Ii) and Mercury (Ii) Complexes Derived From N-Salicylidene Schiff Bases

Aly, Aref A. M.; Osman, Ahmed H.; El-Mottaleb, M. A.; Gouda, Gamal A.

doi:10.4067/s0717-97072009000400005

Cited by 6 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From Figures 9 and 10, it is to be concluded that the thermal dеcomposition of the Cu nano complex generally involves overlapping steps, which together with the great diversity of possible intermediate products. [27,28] 3.9 | Electronic absorption spectra, EAS…”

Section: Thermal Analysismentioning

confidence: 99%

Novel Nano Copper Complexes of a New Schiff Base: Green Synthesis, a New Series of Solid Cr(II), Co(II), Cu(II), Pd(II) and Cd(II) Chelates, Characterization, DFT, DNA, Antitumor and Molecular Docking Studies

Hosny

Gouda

Abu‐El‐Wafa

2022

Applied Organom Chemis

View full text Add to dashboard Cite

A new series of solid Cr(II), Co(II), Cu(II), Pd(II), and Cd(II) chelates of the 1-((E)-(2-mercaptophenylimino)methyl)naphthalen-2-ol (H 2 L) Schiff base ligand were synthеsized and chаracterized by diffеrent аnalytical and spectroscopic tеchniques. The results revealed the geometry around central metal ion to be tetrahedral for Cr 2 L 2 , Co 2 L 2 , Cu 2 L 2 , and Cd 2 L 2 complexes and square planar geometry around Pd 2 L 2 complex. 3D modeling of the ligand and its metal complexes was obtained using DFT/B3LYP method with LANL2DZ basis set. Also quantum-mechanical properties like molecular orbitals and molecular energies were calculated. The Cu nano complexes were prepared in different media Spinacia oleracea (SO), Corchorus olitorius (CO), Coriandrum sativum (CS), Eruca sativa (ES), and Anethum graveolens (AG) extract in EtOH. The particle size of the nano coordination Cu complexes depends on the high concentration of reducing agent present in the green leaf extract. The nature of the newly nano sizеd Cu complexes prepared in different media as crystalline or amorphous and particles size was determined by X-ray diffraction (XRD); scanning electron microscope (SEM). The Cu nano complexes are characterized by spectroscopic and thermal analysis techniques before heating and after heating upon 200 C. The Cu nano complexes were showed an antitumor activity towards hepatocellular carcinoma cell line (HepG-2). The antitumor data revealed that the Cu nano complex prepared in CS/EtOH (IC 50 $ 4.9 μg ml À1 ) has antitumor activity nearly to the activity of cis-platin (IC50 $ 1.143 μg ml À1 ). The DNA cleavage study showed that the ability for the screened Cu nano complex prepared in CS/EtOH to cleavage DNA. Therefore, it may be used as antitumor drugs in vivo to prevent the DNA replication in the tumor cells and to suppress the cancer for further increasing. Docking studies of the ligand and its Cu(II) complex showed good binding energy score ranging from (À4.73 to À5.98 kcal mol À1 ).

show abstract

Section: Thermal Analysismentioning

confidence: 99%