“…Puerarin (PUE, 7,4ʹ-dihydroxy-8-C-glucosylisoflavone) (Figure S1) is a type of natural isoflavonoid C-glycoside derived from Pueraria radix, a traditional Chinese herbal medicine (Liu et al, 2017). It is known to possess several biological activities such as antioxidant, anticancer, antithrombotic, antihyperglycemic, and anti-inflammatory effects and is widely used for treating coronary heart disease, myocardial infarction, angina pectoris, arteriosclerosis, hypertension, and Alzheimer's disease (Li et al, 2019;Zhong et al, 2021). Daidzein (DAI, 4ʹ,7-dihydroxyisoflavone) (Figure S1) is the aglycone of PUE, and it is also a type of biological isoflavone mainly derived from foods such as apples, beans, and nuts as well as from some traditional Chinese herbal medicines including Kudzu and Pueraria lobata (Chen et al, 2001;Wang et al, 2019).…”