Thermal Extrusion 3D Printing for the Fabrication of Puerarin Immediate-Release Tablets

Li, Pingfei; Jia, Haoyue; Zhang, Shiming; Yang, Yining; Sun, Huimin; Wang, Haoyu; Pan, Weisan; Yin, Fei; Yang, Xinggang

doi:10.1208/s12249-019-1538-1

Cited by 22 publications

(14 citation statements)

References 42 publications

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“…With the increase in PEG 4000, an increase in hardness and drug release rate was observed while the friability was kept consistently low despite the changes. It was also demonstrated that PEG 4000 could improve the solubility of puerarin at a ratio of puerarin to PEG 4000 of 1:5, so this was chosen as the optimal ratio [ 73 ]. In addition, there was an interesting recent study describing the preparation of clindamycin palmitate hydrochloride 3D-printed tablets (printlets) by SLS [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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The aim of this review is to present the factors influencing the mechanical properties of 3D-printed oral dosage forms. It also explores how it is possible to use specific excipients and printing parameters to maintain the structural integrity of printed drug products while meeting the needs of patients. Three-dimensional (3D) printing is an emerging manufacturing technology that is gaining acceptance in the pharmaceutical industry to overcome traditional mass production and move toward personalized pharmacotherapy. After continuous research over the last thirty years, 3D printing now offers numerous opportunities to personalize oral dosage forms in terms of size, shape, release profile, or dose modification. However, there is still a long way to go before 3D printing is integrated into clinical practice. 3D printing techniques follow a different process than traditional oral dosage from manufacturing methods. Currently, there are no specific guidelines for the hardness and friability of 3D printed solid oral dosage forms. Therefore, new regulatory frameworks for 3D-printed oral dosage forms should be established to ensure that they meet all appropriate quality standards. The evaluation of mechanical properties of solid dosage forms is an integral part of quality control, as tablets must withstand mechanical stresses during manufacturing processes, transportation, and drug distribution as well as rough handling by the end user. Until now, this has been achieved through extensive pre- and post-processing testing, which is often time-consuming. However, computational methods combined with 3D printing technology can open up a new avenue for the design and construction of 3D tablets, enabling the fabrication of structures with complex microstructures and desired mechanical properties. In this context, the emerging role of computational methods and artificial intelligence techniques is highlighted.

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Section: Resultsmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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“…Puerarin (PUE, 7,4ʹ-dihydroxy-8-C-glucosylisoflavone) (Figure S1) is a type of natural isoflavonoid C-glycoside derived from Pueraria radix, a traditional Chinese herbal medicine (Liu et al, 2017). It is known to possess several biological activities such as antioxidant, anticancer, antithrombotic, antihyperglycemic, and anti-inflammatory effects and is widely used for treating coronary heart disease, myocardial infarction, angina pectoris, arteriosclerosis, hypertension, and Alzheimer's disease (Li et al, 2019;Zhong et al, 2021). Daidzein (DAI, 4ʹ,7-dihydroxyisoflavone) (Figure S1) is the aglycone of PUE, and it is also a type of biological isoflavone mainly derived from foods such as apples, beans, and nuts as well as from some traditional Chinese herbal medicines including Kudzu and Pueraria lobata (Chen et al, 2001;Wang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Interactions between puerarin/daidzein and micellar casein

Wang

Min

Qin

et al. 2022

Journal of Food Biochemistry

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Puerarin (PUE) and daidzein (DAI) are polyphenols with extensive biological activities. In the present study, the interactions between PUE/DAI and micellar casein (MC) were investigated, and the physicochemical properties of their complexes were analyzed. The results of fluorescence spectrum analysis and molecular docking revealed that the main interactions between DAI and MC were hydrophobic forces, while that between PUE and MC was hydrogen bonding. The FTIR and XRD analyses confirmed the formation of complexes between MC and PUE/DAI. After binding to PUE/DAI, the size of MC increased. The weight loss rate of MC decreased after complexing with PUE/DAI, but its morphology was not extensively modified. The DPPH radical scavenging capacities of PUE-MC and DAI-MC complexes were higher than those of free PUE/DAI in both water and ethanol. In vitro release experiments showed that the release rate of PUE/DAI was inhibited by MC under simulated intestinal conditions. Practical applicationsThe low water solubility and poor bioavailability of PUE and DAI limit their application. Micellar casein has high affinity for PUE and DAI. After encapsulated by micellar casein, the release rates of PUE and DAI were prolonged during simulated intestinal digestion. The results would provide useful information for improving the solubility and bioavailability of PUE and DAI, and broadening the use of them in the food and pharmaceutical industry.

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“…In SSE, the starting material is a semisolid or semi-molten material, whereas in FDM and DPE the printing material is in the form of a solid filament or powder, respectively (17,(40)(41)(42). In the literature, SSE is J o u r n a l P r e -p r o o f also known as pressure-assisted microsyringe (PAM) printing (43)(44)(45), robocasting or robotic material extrusion (46), cold extrusion-based printing (47), hydrogel-forming extrusion (48), melting extrusion (48), thermal extrusion (49), soft-material extrusion (48), melting solidification printing process (50), direct ink writing (51), hot-melt ram extrusion (52), hot-melt pneumatic extrusion (53) and micro-extrusion (54).…”

Section: Introductionmentioning

confidence: 99%

Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

Seoane-Viaño

Januskaite

Álvarez-Lorenzo

et al. 2021

Journal of Controlled Release

198

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Thermal Extrusion 3D Printing for the Fabrication of Puerarin Immediate-Release Tablets

Cited by 22 publications

References 42 publications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

Interactions between puerarin/daidzein and micellar casein

Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

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