Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

Seoane-Viaño, Iria; Januskaite, Patricija; Álvarez-Lorenzo, Carmen; Basit, Abdul W.; Goyanes, Álvaro

doi:10.1016/j.jconrel.2021.02.027

Cited by 201 publications

(106 citation statements)

References 162 publications

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“…Fused deposition modelling (FDM) and Semi Solid Extrusion (SSE) are the most straightforward technologies to prepare different mixtures and combinations Pharmaceutics 2021, 13, 907 2 of 16 of drugs and excipients, where the active pharmaceutical ingredient (API) is directly blended with or impregnated in the excipient/carrier to subsequently be processed. Seoane-Viaño et al [18] did a thorough review of SSE, highlighting the numerous applications this technology has and discussing some of its drawbacks: post-printing drying process, complete solvent evaporation, risk of material collapse and loss of shape. On the contrary, FDM does not show those post processing problems, but it is limited by the low number of Food and Drug Administration (FDA) approved thermoplastic polymers and the thermal degradation the drug undergoes during the process [14,19,20].…”

Section: Introductionmentioning

confidence: 99%

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Mendibil

Tena

Duque³

et al. 2021

Pharmaceutics

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Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible carrier that permits the thermal processing of the mixture at temperature levels that are safe for the drug is an important field of study. Here, potato starch and hydroxypropyl cellulose based mixtures loaded with paracetamol up to 50% in weight were processed by hot melt extrusion at 85 °C to test their suitability to be thermally processed. The extruded mixtures were tested by liquid chromatography to analyze their release curves and were thermally characterized. The drug recovery was observed to be highly dependent on the initial moisture level of the mixture, the samples being prepared with an addition of water at a ratio of 3% in weight proportional to the starch amount, highly soluble and easy to extrude. The release curves showed a slow and steady drug liberation compared to a commercially available paracetamol tablet, reaching the 100% of recovery at 60 min. The samples aged for 6 weeks showed slower drug release curves compared to fresh samples, this effect being attributable to the loss of moisture. The paracetamol loaded mixture in powder form was used to print pills with different sizes and geometries in a fused deposition modelling three-dimensional printer modified with a commercially available powder extrusion head, showing the potential of this formulation for use in personalized medicine.

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Section: Introductionmentioning

confidence: 99%

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Mendibil

Tena

Duque³

et al. 2021

Pharmaceutics

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“…Special patient populations were actively acknowledged in the movement, exemplified by the case of 3DP tablets incorporating Braille designs for the visually impaired [37,38]. Bioprinting, a branch of 3DP capable of printing living cells, was also conceived, promising a future of 3DP organs and probiotic therapies [39][40][41][42]. Despite encouraging results when tested in vitro and in vivo using animal models of disease, few 3DP pharmaceuticals have entered human studies and none has followed in the footsteps of Spritam® with market approval.…”

Section: Moving 3dp Of Pharmaceuticals Beyond the Laboratory And Into The Clinicmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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“…Generally, an incredible advantage of 3D printing is the possibility of the fabrication of complex structures, unprofitable to manufacture using injection molding methods [5]. Furthermore, 3D printers have been improved for extremely high resolution, which fosters their use in tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Advances in 3D Printing for Tissue Engineering

et al. 2021

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Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

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Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

Cited by 201 publications

References 162 publications

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Disrupting 3D printing of medicines with machine learning

Advances in 3D Printing for Tissue Engineering

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