Thermal exposure effects on the in vitro degradation and mechanical properties of Mg–Sr and Mg–Ca–Sr biodegradable implant alloys and the role of the microstructure

Bornapour, Mosayeb; Çelikin, Mert; Pekguleryuz, Mihriban

doi:10.1016/j.msec.2014.10.008

Cited by 42 publications

(30 citation statements)

References 29 publications

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“…70 On account of these benefits, Sr has been used in Mg alloys for biomedical applications. Bornapour et al 37,54 showed that Sr promotes the formation of the Sr-HA layer on the Mg-Sr alloy implant after implantation into a rabbit. Bornapour et al 37,54 showed that Sr promotes the formation of the Sr-HA layer on the Mg-Sr alloy implant after implantation into a rabbit.…”

Section: Biocompatibilities Of Zr and Srmentioning

confidence: 99%

“…27 However, the amount of released Zn can become overly high through the degradation of Mg alloys with high Zn concentrations. 36,37 Considering the benefits in the biomechanical properties, biocorrosion and biocompatibility of Zr and Sr, a novel series of Mg-Zr-Sr alloys have been developed considering the various benefits of Sr and Zr in Mg alloys. [29][30][31] The Zn cation acts as a mediated inhibitor of neurotrophins and can even lead to cell death, 32 and Zn accumulation in the human body may induce embryonic motor neuron death and affect mature motor neurons.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

Ding

Lin³

et al. 2015

J. Mater. Chem. B

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The successful applications of magnesium (Mg) alloys as biodegradable orthopedic implants are mainly restricted due to their rapid degradation rate in the physiological environment, leading to a loss of mechanical integrity. This study systematically investigated the degradation behaviors of novel Mg-Zr-Sr alloys using electrochemical techniques, hydrogen evolution, and weight loss in simulated body fluid (SBF). The microstructure and degradation behaviors of the alloys were characterized using optical microscopy, XRD, SEM, and EDX. The results indicate that Zr and Sr concentrations in Mg alloys strongly affected the degradation rate of the alloys in SBF. A high concentration of 5 wt% Zr led to acceleration of anodic dissolution, which significantly decreased the biocorrosion resistance of the alloys and their biocompatibility. A high volume fraction of Mg 17 Sr 2 phases due to the addition of excessive Sr (over 5 wt%) resulted in enhanced galvanic effects between the Mg matrix and Mg 17 Sr 2 phases, which reduced the biocorrosion resistance. The average Sr release rate is approximately 0.15 mg L À1 day À1 , which is much lower than the body burden and proves its good biocompatibility. A new biocorrosion model has been established to illustrate the degradation of alloys and the formation of degradation products on the surface of the alloys. It can be concluded that the optimal concentration of Zr and Sr is less than 2 wt% for as-cast Mg-Zr-Sr alloys used as biodegradable orthopedic implants. Fig. 16 Schematic model for biocorrosion propagation of Mg-Zr-Sr alloys in SBF: (a) dissolution of the Mg matrix due to galvanic effects; (b) the partially protective film of Mg(OH) 2 ; (c) dissolution of Mg(OH) 2 due to deterioration by Cl À ; (d) formation of HA; (e) corrosive residues escaping from the Mg matrix.

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Section: Biocompatibilities Of Zr and Srmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

Ding

Lin³

et al. 2015

J. Mater. Chem. B

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“…A network structure almost formed as a result of the isolation of the Mg 17 Sr 2 phase. However, owing to the heterogeneous distribution of the Mg 17 Sr 2 phase, this network structure was not complete, which caused the nonuniform degradation of as-cast Mg5Zr2Sr, as shown in Figure 6a, e, and i. Gu et al [10] and Bornapour et al [23] indicated that the increased degradation rate of MgxSr alloys was caused by the potential difference of the two phases, since Mg 17 Sr 2 phase is more inert than the Mg matrix. The potential difference led to the galvanic effects between the Mg 17 Sr 2 phase and the Mg matrix.…”

Section: Effect Of Sr On the Corrosion Resistance Of Mg5zrxsr Alloysmentioning

confidence: 99%

Effects of Mg₁₇Sr₂ Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys

Ding

Wen

2015

Adv Eng Mater

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The effect of the second phase Mg 17 Sr 2 on the biocorrosion behavior of Mg5ZrxSr (x ¼ 0, 2, 5 wt%) alloys before and after solution treatment was investigated. Electrochemical impedance spectroscopy, cathodic polarization and hydrogen evolution were used to evaluate the biocorrosion of Mg5ZrxSr. We found that Mg 17 Sr 2 precipitated on boundary zones and enhanced the galvanic effect, leading to a severer corrosion of the Mg matrix adjacent to Mg 17 Sr 2 . The corrosion subsequently spread gradually from the regions adjacent to the Mg 17 Sr 2 to the central Mg matrix. However, a high volume fraction of Mg 17 Sr 2 could also form a continuous network, isolate the Mg matrix and act as a barrier of corrosion.

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“…With 14 of 31 significant regression analyses, the relation between controlled mechanical integrity and degradation (MR 1) and the composition (EC A) verifies and reflects the current research focus on the composition to improve and control the corrosion process. Various biocompatible and nontoxic magnesium‐based alloys have already been investigated, such as: Mg–Ca (Li et al, ; Seong & Kim, ; Zeng et al, ), Mg–Zn (Zhang et al, ), Mg‐Zr (Li et al, ), Mg–Sr (Bornapour, Celikin, & Pekguleryuz, ; Gu et al, ; Zhao, Pan, & Pan, ), Mg–Si (Gil‐Santos, Marco, Moelans, Hort, & Van der Biest, ), Mg–Sn (Zhao et al, ), Mg–Ge (Bian et al, ), Mg–REE (Hort et al, ), Mg–Zn–Ca (Cipriano et al, ; Fazel Anvari‐Yazdi et al, ) and Mg–Si–Ca–Zn (Zhao et al, ). The results of the regression analysis also confirmed the interrelation between the control of degradation (MR 1) and the structure (EC C).…”

Section: Discussionmentioning

confidence: 99%

“…Various biocompatible and nontoxic magnesium-based alloys have already been investigated, such as: Mg-Ca (Li et al, 2008;Seong & Kim, 2015;Zeng et al, 2015), Mg-Zn , Mg-Zr , Mg-Sr (Bornapour, Celikin, & Pekguleryuz, 2015;Gu et al, 2012;Zhao, Pan, & Pan, 2016), Mg-Si (Gil-Santos, Marco, Moelans, Hort, & Van der Biest, 2017), Mg-Sn ,…”

Section: Discussionmentioning

confidence: 99%

Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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Biodegradable magnesium‐based implants are the subject of a great deal of research for different orthopedic and vascular applications. The targeted design and properties depend on the specific medical function and location in the body. Development of the biomaterial requires a comprehensive understanding of the biological interaction between the implant and the host tissue, as well as of the behavior in the physiological environment in vivo. Research into and the development of innovative magnesium implants entails interdisciplinary research efforts and communication between materials science, bioscience, and medical experts. The present study provides a transparent planning and communication tool for market‐oriented implant development processes. The objective was to identify medical needs at an early stage of the development process and to quantify the importance of the engineering characteristics of different research fields that cater to specific implant requirements. The method is demonstrated by the performance of a survey‐based conjoint analysis, which was integrated into a quality function deployment approach. Twenty‐seven medical professionals and 29 biomaterial scientists assessed the importance of identified medical requirements, whereby the control of mechanical integrity and degradation along with nontoxicity and nonimmunogenicity showed the highest number of preferences. The evaluation of implant options by 31 experts indicated that the engineering characteristic with the highest importance was the condition and sterilization of the surface. These values can be used to set priorities in strategic decisions. Research trials can be aligned to medical preferences, ensuring high product quality and an effective development process. This is the first paper to report on the application of conjoint‐based quality function deployment in biomaterial research.

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Thermal exposure effects on the in vitro degradation and mechanical properties of Mg–Sr and Mg–Ca–Sr biodegradable implant alloys and the role of the microstructure

Cited by 42 publications

References 29 publications

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

Effects of Mg₁₇Sr₂ Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys

Development of magnesium implants by application of conjoint‐based quality function deployment

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Thermal exposure effects on the in vitro degradation and mechanical properties of Mg–Sr and Mg–Ca–Sr biodegradable implant alloys and the role of the microstructure

Cited by 42 publications

References 29 publications

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

Effects of zirconium and strontium on the biocorrosion of Mg–Zr–Sr alloys for biodegradable implant applications

Effects of Mg17Sr2 Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys

Development of magnesium implants by application of conjoint‐based quality function deployment

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Effects of Mg₁₇Sr₂ Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys