Effects of Mg<sub>17</sub>Sr<sub>2</sub> Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys

Ding, Yong; Li, Yuncang; Wen, Cuié

doi:10.1002/adem.201500222

Cited by 25 publications

(10 citation statements)

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“…The results of the immersion tests confirmed that the galvanic effect is promoted in the interface area near Mg 17 Sr 2 fragments [ 18 ], which facilitates the corrosion of the Mg matrix adjacent to the intermetallic phase. With immersion time, corrosion-induced degradation gradually spreads from to the interior of Mg grains, which is consistent with the results reported in [ 35 ]. The highest corrosion rate of 0.91 mm/y after 30 days of immersion was observed in the coarse-grained state with manifestation of large and deep corrosion pits on the surface after a week of immersion.…”

Section: Discussionsupporting

confidence: 92%

Microstructural Assessment, Mechanical and Corrosion Properties of a Mg-Sr Alloy Processed by Combined Severe Plastic Deformation

et al. 2023

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The development of high-performance biodegradable alloys with controllable corrosion rates to be used for manufacturing advanced implants is a hot topic of modern materials science and biomedicine. This work features the changes in microstructure, corrosion behavior and mechanical properties of the Mg-2 wt.%Sr alloy progressively induced by equal-channel angular pressing, high-pressure torsion and annealing. We show that such processing leads to significant microstructure refinement including diminishing grain size, defect accumulation and fragmentation of the initial eutectics. We demonstrate that the application of severe plastic deformation and heat treatment is capable of considerably enhancing the mechanical and corrosion performance of a biodegradable alloy of the Mg-Sr system. The best trade-off between strength, plasticity and the corrosion resistance has been achieved by annealing of the Mg-Sr alloy subjected to combined severe plastic deformation processing.

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Section: Discussionsupporting

confidence: 92%

Microstructural Assessment, Mechanical and Corrosion Properties of a Mg-Sr Alloy Processed by Combined Severe Plastic Deformation

et al. 2023

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“…Figure 1A shows the OM, SEM images and corresponding EDS diagram of the Mg-1Zn-1Sn and Mg-1Zn-1Sn-0.2Sr alloys. From the OM images, the grain size was slightly reduced from 26 ± 3 µm to 20 ± 2 µm with the incorporation of Sr, which is consistent with a previous study indicating that Sr has the effect of grain refinement [23][24][25]. With the addition of Sr, the second phase (bright spot) in the alloy matrix increases, the volume fraction of the second phase increased from 0.5% (Mg-1Zn-1Sn) to 1.1% (Mg-1Zn-1Sn-0.2Sr).…”

Section: Microstructures and Electrochemical Evaluationssupporting

confidence: 91%

In Vitro Studies on Mg-Zn-Sn-Based Alloys Developed as a New Kind of Biodegradable Metal

et al. 2021

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Mg-Zn-Sn-based alloys are widely used in the industrial field because of their low-cost, high-strength and heat-resistant characteristics. However, their application in the biomedical field has been rarely reported. In the present study, biodegradable Mg-1Zn-1Sn and Mg-1Zn-1Sn-0.2Sr alloys were fabricated. Their microstructure, surface characteristics, mechanical properties and bio-corrosion properties were carried out using an optical microscope (OM), X-ray diffraction (XRD), electron microscopy (SEM), mechanical testing, electrochemical and immersion test. The cell viability and morphology were studied by cell counting kit-8 (CCK-8) assay, live/dead cell assay, confocal laser scanning microscopy (CLSM) and SEM. The osteogenic activity was systematically investigated by alkaline phosphatase (ALP) assay, Alizarin Red S (ARS) staining, immunofluorescence staining and quantitative real time-polymerase chain reaction (qRT-PCR). The results showed that a small amount of strontium (Sr) (0.2 wt.%) significantly enhanced the corrosion resistance of the Mg-1Zn-1Sn alloy by grain refinement and decreasing the corrosion current density. Meanwhile, the mechanical properties were also improved via the second phase strengthening. Both Mg-1Zn-1Sn and Mg-1Zn-1Sn-0.2Sr alloys showed excellent biocompatibility, significantly promoted cell proliferation, adhesion and spreading. Particularly, significant increases in ALP activity, ARS staining, type I collagen (COL-I) expression as well as the expressions of three osteogenesis-related genes (runt-related transcription factor 2 (Runx2), osteopontin (OPN), and osteocalcin (Bglap)) were observed for the Mg-1Zn-1Sn-0.2Sr group. In summary, this study demonstrated that Mg-Zn-Sn-based alloy has great application potential in orthopedics and Sr is an ideal alloying element of Mg-Zn-Sn-based alloy, which optimizes its corrosion resistance, mechanical properties and osteoinductive activity.

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“…In general, the corrosion of the Mg matrix primarily starts from the interfacial Mg matrix adjacent to the intermetallic phases. 36 Through analysis of the polarization tests on the Mg 17 Sr 2 and Mg 2 Dy phases, it can be seen that Mg 17 Sr 2 is relatively inert, as indicated by its higher corrosion potential and lower current density compared with those of Mg 2 Dy. Mg 2 Dy phases in grain boundaries may distribute at the interfaces between the Mg 17 Sr 2 intermetallic phase and the Mg matrix during rapid cooling (Figure 3).…”

Section: Corrosion Behavior Of Mg Alloysmentioning

confidence: 99%

Mechanical properties, corrosion, and biocompatibility of Mg‐Zr‐Sr‐Dy alloys for biodegradable implant applications

Ding

Lin²,

Wen

et al. 2017

J Biomed Mater Res

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This study investigates the microstructure, mechanical properties, corrosion behavior, and biocompatibility of magnesium (Mg)-based Mg1Zr2SrxDy (x = 0, 1, 1.63, 2.08 wt %) alloys for biodegradable implant applications. The corrosion behavior of the Mg-based alloys has been evaluated in simulated body fluid using an electrochemical technique and hydrogen evolution. The biocompatibility of the Mg-based alloys has been assessed using SaSO2 cells. Results indicate that the addition of Dy to Mg-Zr-Sr alloy showed a positive impact on the corrosion behavior and significantly decreased the degradation rates of the alloys. The degradation rate of Mg1Zr2Sr1.0Dy decreased from 17.61 to 12.50 mm year of Mg1Zr2Sr2.08Dy based on the hydrogen evolution. The ultimate compressive strength decreased from 270.90 MPa for Mg1Zr2Sr1Dy to 236.71 MPa for Mg1Zr2Sr2.08Dy. An increase in the addition of Dy to the Mg-based alloys resulted in an increase in the volume fraction of the Mg Dy phase, which mitigated the galvanic effect between the Mg Sr phase and the Mg matrix, and led to an increase in the corrosion resistance of the base alloy. The biocompatibility of the Mg-based alloys was enhanced with decreasing corrosion rates. Mg1Zr2Sr2.08Dy exhibited the lowest corrosion rate and the highest biocompatibility compared with the other Mg-based alloys. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2425-2434, 2018.

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Effects of Mg₁₇Sr₂ Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys

Cited by 25 publications

References 23 publications

Microstructural Assessment, Mechanical and Corrosion Properties of a Mg-Sr Alloy Processed by Combined Severe Plastic Deformation

Microstructural Assessment, Mechanical and Corrosion Properties of a Mg-Sr Alloy Processed by Combined Severe Plastic Deformation

In Vitro Studies on Mg-Zn-Sn-Based Alloys Developed as a New Kind of Biodegradable Metal

Mechanical properties, corrosion, and biocompatibility of Mg‐Zr‐Sr‐Dy alloys for biodegradable implant applications

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Effects of Mg17Sr2 Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys

Cited by 25 publications

References 23 publications

Microstructural Assessment, Mechanical and Corrosion Properties of a Mg-Sr Alloy Processed by Combined Severe Plastic Deformation

Microstructural Assessment, Mechanical and Corrosion Properties of a Mg-Sr Alloy Processed by Combined Severe Plastic Deformation

In Vitro Studies on Mg-Zn-Sn-Based Alloys Developed as a New Kind of Biodegradable Metal

Mechanical properties, corrosion, and biocompatibility of Mg‐Zr‐Sr‐Dy alloys for biodegradable implant applications

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Effects of Mg₁₇Sr₂ Phase on the Bio‐Corrosion Behavior of Mg–Zr–Sr Alloys