Thermal compatibility studies of nitroimidazoles and excipients

Pinto, Márcia Ferraz; Moura, Elisana Afonso de; Souza, Fábio Santos de; Macêdo, Rui Oliveira

doi:10.1007/s10973-010-0889-3

Cited by 24 publications

(5 citation statements)

References 21 publications

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“…It is important to note that for the AMX-talc mixtures, the peak intensity of the extract significantly changed, as observed for the AMX-colloidal silicon dioxide mixtures. Once again, this phenomenon can be attributed to the siloxane groups in the pharmaceutical excipient, the presence of which causes an intense absorption at 1080 cm − 1 , thus promoting attenuation of the other spectral bands [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

et al. 2019

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The use of biocompatible polymers such as Hydroxypropylmethylcellulose (HPMC), Hydroxyethylcellulose (HEC), Carboxymethylcellulose (CMC), and Carbopol in solid formulations results in mucoadhesive systems capable of promoting the prolonged and localized release of Active Pharmaceutical Ingredients (APIs). This strategy represents a technological innovation that can be applied to improving the treatment of oral infections, such as oral candidiasis. Therefore, the aim of this study was to develop a tablet of Ximenia americana L. from mucoadhesive polymers for use in the treatment of oral candidiasis. An X. americana extract (MIC of 125 μg·mL−1) was obtained by turbolysis at 50% of ethanol, a level that demonstrated activity against Candida albicans. Differential Thermal Analysis and Fourier Transform Infrared Spectroscopy techniques allowed the choice of HPMC as a mucoadhesive agent, besides polyvinylpyrrolidone, magnesium stearate, and mannitol to integrate the formulation of X. americana. These excipients were granulated with an ethanolic solution 70% v/v at PVP 5%, and a mucoadhesive tablet was obtained by compression. Finally, mucoadhesive strength was evaluated, and the results demonstrated good mucoadhesive forces in mucin disk and pig buccal mucosa. Therefore, the study allowed a new alternative to be developed for the treatment of buccal candidiasis, one which overcomes the inconveniences of common treatments, costs little, and facilitates patients’ adhesion.

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Section: Resultsmentioning

confidence: 99%

Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

et al. 2019

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“…4i) occurred at 400°C. Other authors also used DSC coupled to a photovisual system [22][23][24][25] and confirmed the parameters obtained by DSC and TG. This technique is an important tool to confirm events in special melting.…”

Section: Resultsmentioning

confidence: 59%

“…The structures of guanylhydrazones studied in this study are the following: Thermogravimetry (TG) and differential scanning calorimetry (DSC) are thermal techniques widely distributed and used in pharmaceutical analyses. These techniques are used in studies of drug characterization, purity, compatibility studies, polymorphism identification, stability evaluation, thermal decomposition of drugs, and development of pharmaceutical formulations [19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

galvão

Brito

Dantas

et al. 2014

J Therm Anal Calorim

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2-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylene]-hydrazinecarboximidamide (WE010), 2-([1,1 0 -biphenyl]-4-ylmethylene)-hydrazinecarboximidamide (WE014), and 2-[(3,4-dichlorophenyl)methylene]-hydrazinecarboximidamide (WE017) are guanylhydrazone derivatives widely studied biologically and chemically; however, there are no studies regarding their thermal behaviors. The present study aims to apply the thermal analyses: differential scanning calorimetry (DSC), differential scanning calorimetry coupled to the photovisual system (DSC-photovisual), and thermogravimetry (TG), to characterize the guanylhydrazones, as well as HPLC and FTIR. The DSC curve of WE010 shows a melting process with T onset at 190°C and peak at 193.5°C (DH 41.0 J g -1 ). Due to the symmetry of the melting peaks obtained by DSC, it is possible to calculate the purity of the sample (98.87 %). The DSC curve of WE014 shows the melting process in the range of 208-213°C, with a melting peak at 211°C (DH 61 J g -1 ).The DSC curve of WE017 showed T onset at 215°C and peak temperature of 219°C (DH 55 J g -1 ). The TG curve of WE010, WE014, and WE017 presents initial decomposition temperatures of 186.95, 197.31, and 195.44°C, respectively. The DSC-photovisual confirmed the results of DSC and TG. The HPLC determined the purities of the samples and confirmed the results of DSC. The FTIR confirmed the thermal data. Thus, the use of thermal analysis is an important tool for the characterization of molecules with therapeutic potential contributing to the characterization and evaluation of their stability as well as nonthermal technique with complementary tool.

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“…Physical and a chemical interaction between drug and excipients can affect the chemical nature, stability, bioavailability of product, therapeutics efficacy and safety. [4][5][6] Thermoanalytical techniques measure the changes in physical or chemical properties of the sample as a function of temperature. There are many possible applications in pharmaceutical industry, for example, identification, characterization of active and inactive ingredients, routine analysis, quality control and stability study.…”

Section: Introductionmentioning

confidence: 99%

Incompatibility studies by high performance thin-layer chromatography: In case of curcumin

Shrivastava¹,

Sharma²,

Aggrawal³

et al. 2013

Asian J Pharm

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C urcumin[1,7-bis (4-hydroxy-3-methoxy-phenyl) hepta-1, 6-diene-3, 5-dione] is one of the component present in the turmeric. Curcumin has been in use for its medicinal benefits since centuries and its therapeutic potential is continuously explored through various researchers throughout the world. To investigate the interaction of curcumin with commonly used excipients such as microcrystalline cellulose, starch, colloidal silica, talc, ascorbic acid, lactose, ethyl cellulose (EC), sodium carboxymethylcellulose (Na-CMC), hydroxyl propyl methyl cellulose and magnesium stearate. High performance thin-layer chromatography (HPTLC) is commonly used technique for the determination of phytoconstituents, but its application in incompatibility studies is still not investigated. Thus, we initiated our study with HPTLC followed by Fourier transform infrared and differential scanning calorimetry. Since interaction of curcumin with ascorbic acid, EC, Na-CMC and Mg-stearate confirmed by all three techniques these four excipients should be avoided during the formulation development of curcumin. The presented study also establishes HPTLC's usefulness in such interaction studies.

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Thermal compatibility studies of nitroimidazoles and excipients

Cited by 24 publications

References 21 publications

Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

Incompatibility studies by high performance thin-layer chromatography: In case of curcumin

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