Thermal and pH stability of spray-dried encapsulated astaxanthin oleoresin from Haematococcus pluvialis using several encapsulation wall materials

Bustos-Garza, Cecilia; Yáñez-Fernández, Jorge; Barragán-Huerta, Blanca E.

doi:10.1016/j.foodres.2013.07.061

Cited by 133 publications

(71 citation statements)

References 45 publications

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“…The resulting solution was stirred for 2 h to achieve complete dissolution. This solution was spray dried in a Lab scale spray dryer LU-227 (Lab Ultima, India), with inlet temperature 102°C, outlet temperature 60-65°C, flow rate of the solution 400 mL/h, airflow rate 40-50 m 3 /h and atomizing air pressure 1.0-1.1 bar [5].…”

Section: Phase Solubility Studymentioning

confidence: 99%

Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Nalawade

Anuradha

2015

J Incl Phenom Macrocycl Chem

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Lutein (LUT) is one of the most important carotenoid and; the most prominent being its antioxidant activity. However, its use is limited due to poor solubility and instability under adverse conditions. An attempt is made to increase the solubility and hence bioavailability of LUT using various cyclodextrins viz., betacyclodextrin (bCD), hydroxypropyl betacyclodextrin (HP-bCD) and methyl betacyclodextrin (M-bCD). Physical mixtures and spray dried inclusion complexes were prepared and characterized using spectroscopic techniques, DSC and XRD studies. From the phase solubility and dissolution studies it was found that, M-bCD significantly improved the solubility of LUT. These complexes were further subjected to in vitro anti-proliferative activity in order to validate results obtained from solubility studies. The biological results were in congruence with the results of solubility studies. Spray dried complex of LUT:M-bCD showed significant percent growth inhibition as compared to other two complexes and LUT alone. Molecular modeling studies established the hostguest stoichiometry with the lowest energy to be 2:1, with the two hexatomic rings of a LUT molecule occupying the two M-bCD cavities. The present study forms the basis for the development of oral formulations of LUT with significantly improved solubility and bioavailability.

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Section: Phase Solubility Studymentioning

confidence: 99%

Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Nalawade

Anuradha

2015

J Incl Phenom Macrocycl Chem

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“…Nanosized carriers, such as oil drops, polymers, lipoproteins, liposomes and micelles allow one to prepare water dispersions of carotenoids with enhanced stability (Hou, Liu, Lei, & Gao, 2014;Toniazzo et al, 2014;Tan et al, 2014;Ascenso et al, 2013;Luxsuwong, Indranupakorn, & Wongtrakul, 2014;Donhowe & Kong, 2014;Acevedo et al, 2014;Bustos-Garza, Yanez-Fernandez, & Barragan-Huerta, 2013).…”

Section: Introductionmentioning

confidence: 99%

Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery

Polyakov

Kispert

2015

Carbohydrate Polymers

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Since carotenoids are highly hydrophobic, air- and light-sensitive hydrocarbon compounds, developing methods for increasing their bioavailability and stability towards irradiation and reactive oxygen species is an important goal. Application of inclusion complexes of "host-guest" type with polysaccharides and oligosaccharides such as arabinogalactan, cyclodextrins and glycyrrhizin minimizes the disadvantages of carotenoids when these compounds are used in food processing (colors and antioxidant capacity) as well as for production of therapeutic formulations. Cyclodextrin complexes which have been used demonstrated enhanced storage stability but suffered from poor solubility. Polysaccharide and oligosaccharide based inclusion complexes play an important role in pharmacology by providing increased solubility and stability of lipophilic drugs. In addition they are used as drug delivery systems to increase absorption rate and bioavailability of the drugs. In this review we summarize the existing data on preparation methods, analysis, and chemical reactivity of carotenoids in inclusion complexes with cyclodextrin, arabinogalactan and glycyrrhizin. It was demonstrated that incorporation of carotenoids into the "host" macromolecule results in significant changes in their physical and chemical properties. In particular, polysaccharide complexes show enhanced photostability of carotenoids in water solutions. A significant decrease in the reactivity towards metal ions and reactive oxygen species in solution was also detected.

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“…However, in some other cases, the influence of pressure produced the opposite effect. Bustos-Garza et al (2013), studying the thermal and pH stability of spray-dried encapsulated astaxanthin, found microcapsules with rounded outer surfaces with particle sizes from 1 to 10 m. Higüera-Ciapara et al (2004), studying the microencapsulation of astaxanthin in a chitosan matrix, found microcapsules with a non-homogeneous size and a diameter of 5-50 m. Kittikaiwan et al (2007), studying the encapsulation of cells from H. pluvialis in chitosan to protect the astaxanthin and its biological activity against oxidative environmental conditions, found capsules with a mean diameter of 0.43 cm and a total film thickness of approximately 100 m. Hong et al (2009), studying the precipitation of astaxanthin from H. pluvialis in supercritical fluid, found values of the particle size between 0.5 and 3 m at experimental conditions of 200 bar and 35 • C. Tachaprutinun et al (2009) reported similar results, a particle size of 0.312 m, when studying the prevention of thermal degradation of com- Table 4. mercial astaxanthin through encapsulation in the polymers poly(ethylene oxide)-4-methoxycinnamoylphthaloylchitosan, poly(vinyl-alcohol-co-vinyl-4-methoxycinnamate) and ethylcellulose.…”

Section: Co-precipitation Of Astaxanthin In Phbvmentioning

confidence: 99%

Technological process for cell disruption, extraction and encapsulation of astaxanthin from Haematococcus pluvialis

Machado

Trevisol

Boschetto

et al. 2016

Journal of Biotechnology

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In this work, the effectiveness of different enzymatic techniques for cell wall disruption of Haematococcus pluvialis for the extraction of carotenoids and subsequent encapsulation of extracts in the co-polymer poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) using the Solution Enhanced Dispersion by Supercritical fluids (SEDS) technique was investigated. Glucanex(®) performed best compared with Lyticase(®) and Driselase(®). The conditions for enzymatic lysis using this enzyme preparation were established as a pH of 4.5, a temperature of 55 °C, an initial activity of β-1,3-glucanase of 0.6 U mL(-1) and a reaction time of 30 min. Enzymatic lysis assisted by ultrasound without biomass freezing was shown to be a promising and simple one-step technique for cell wall disruption, reaching 83.90% extractability. In the co-precipitation experiments, the highest encapsulation efficiency (51.21%) was obtained when using a higher biomass to dichloromethane ratio (10 mg mL(-1)) at the carotenoid extraction step and a lower pressure of precipitation (80 bar). In these conditions, spherical particles in the micrometer range (0.228 μm) were obtained.

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Thermal and pH stability of spray-dried encapsulated astaxanthin oleoresin from Haematococcus pluvialis using several encapsulation wall materials

Cited by 133 publications

References 45 publications

Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery

Technological process for cell disruption, extraction and encapsulation of astaxanthin from Haematococcus pluvialis

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