Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery

Abstract

Since carotenoids are highly hydrophobic, air- and light-sensitive hydrocarbon compounds, developing methods for increasing their bioavailability and stability towards irradiation and reactive oxygen species is an important goal. Application of inclusion complexes of "host-guest" type with polysaccharides and oligosaccharides such as arabinogalactan, cyclodextrins and glycyrrhizin minimizes the disadvantages of carotenoids when these compounds are used in food processing (colors and antioxidant capacity) as well as for production of therapeutic formulations. Cyclodextrin complexes which have been used demonstrated enhanced storage stability but suffered from poor solubility. Polysaccharide and oligosaccharide based inclusion complexes play an important role in pharmacology by providing increased solubility and stability of lipophilic drugs. In addition they are used as drug delivery systems to increase absorption rate and bioavailability of the drugs. In this review we summarize the existing data on preparation methods, analysis, and chemical reactivity of carotenoids in inclusion complexes with cyclodextrin, arabinogalactan and glycyrrhizin. It was demonstrated that incorporation of carotenoids into the "host" macromolecule results in significant changes in their physical and chemical properties. In particular, polysaccharide complexes show enhanced photostability of carotenoids in water solutions. A significant decrease in the reactivity towards metal ions and reactive oxygen species in solution was also detected.

Development and evaluation of lutein‐loaded alginate microspheres with improved stability and antioxidant

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Soluble cyanobacterial carotenoprotein as a robust antioxidant nanocarrier and delivery module

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Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches

“…This should be an exciting avenue for new studies to explore different areas for the use of terpenes. For complementary information, we recommend the excellent reviews published by Brito et al, (2015), Kurkov and Loftsson (2013), Marques (2010a), Oliveira et al, (2015), Pinho et al, (2014), and Polyakov and Kispert (2015). control group (unpaired t-test) (Adapted from Quintans-Júnior et al, 2016).…”