Thermal analysis and calorimetry of pharmaceuticals

Ford, James L.; Willson, Richard J.

doi:10.1016/s1573-4374(99)80020-x

Cited by 15 publications

(8 citation statements)

References 147 publications

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“…While the endothermic peak of MX was highly shifted with a reduced melting endotherm (237.72, 239.14 and 239.94 °C for B4, B6 and B8, respectively); compared to the ground MX powder. It was interesting to observe that the enthalpy was decreased for both MX and lactose as the amount of lactose increased (Table 3), This result might be an indication of the high damage to the crystallinity of both MX and lactose and hence the higher degree of amorphous content (Sebhatu et al, 1994;Ford and Willson, 1999), which have been visually observed by SEM images (Figures 2A-D and 3F-H). Also, these results coincided with observed increase of MX solubility and dissolution (Table 1 and Figure 5).…”

Section: Dscmentioning

confidence: 77%

“…Also, rough treatment of crystalline material, such as grinding, drying or compaction, can cause damage to the crystallinity of the material and hence increase the amorphous nature (Sebhatu et al, 1994;Ford and Willson, 1999). Moreover, the amorphous forms, owing to higher molecular mobility as compared to the equivalent crystalline form, may enhance dissolution rate and this difference can then be used to estimate the degree of amorphous content in a given sample (Shah -et al, 2006), which has been proved by the increase of MX solubility and dissolution by grinding.…”

Section: Dscmentioning

confidence: 99%

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Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam

Emara¹,

El-Ashmawy²,

Taha³

et al. 2016

J App Pharm Sci

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This study explored the effect of nano-crystalline cellulose (NCC) on Meloxicam (MX) solid dispersion (SD) prepared by co-grinding technique compared to micro-crystalline cellulose (MCC) in presence of lactose. MXtablets were prepared by direct compression of different co-ground SDs or physical mixtures. The solubility, dissolution, SEM and DSC of different preparations were studied. Flow-through cell apparatus (FTC) was used to study the dissolution of MX from tablets at pH 7.4. Generally, the results revealed that increasing NCC loadings showed a direct increase in both the solubility and dissolution of MX. MCC did not improve either the solubility or the dissolution of MX in the physical mixture, while, co-grinding dramatically decreased the dissolution rate of MX. It was interesting to find that grinding of MX-powder alone or in a mixture with lactose highly increased MX solubility and dissolution. SEM as well as DSC were found to be very good tools, without a single exception, to describe the observed solubility and dissolution of MX in these proposed preparations. SEM-images showed the particle size reduction upon grinding or co-grinding techniques. While DSC-data proved that the crystalline structure of MX has been changed to an amorphous state.

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Section: Dscmentioning

confidence: 77%

Section: Dscmentioning

confidence: 99%

Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam

Emara¹,

El-Ashmawy²,

Taha³

et al. 2016

J App Pharm Sci

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“…Hygroscopicity refers to the ability of a solid substance to absorb or adsorb moisture from the surrounding atmosphere [32,33]. Owing to their affinity to water, hygroscopic substances can retain moisture and maintain a dampened, hard, and compact road surface, which subsequently prevents the erosion of fugitive dust.…”

Section: Hygroscopicitymentioning

confidence: 99%

“…The detailed description of these mechanisms can be found elsewhere [37]. Interestingly, a hygroscopic substance may deliquesce if its critical relative humidity (CRH) is lower than that of the surrounding atmosphere, i.e., the water adsorbed on the surface of the hygroscopic substance starts to solvate molecules to an extent that the complete substance is liquified [32,38,39]. Often, deliquescent substances (e.g., CaCl 2 , MgCl 2 , FeCl 2 etc.)…”

Section: Hygroscopicitymentioning

confidence: 99%

Fugitive Dust Suppression in Unpaved Roads: State of the Art Research Review

et al. 2021

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Fugitive dust is a serious threat to unpaved road users from a safety and health point of view. Dust suppressing materials or dust suppressants are often employed to lower the fugitive dust. Currently, many dust suppressants are commercially available and are being developed for various applications. The performance of these dust suppressants depends on their physical and chemical properties, application frequency and rates, soil type, wind speed, atmospheric conditions, etc. This article presents a comprehensive review of various available and in-development dust suppression materials and their dust suppression mechanisms. Specifically, the dust suppressants that lower the fugitive dust either through hygroscopicity (ability to absorb atmospheric moisture) and/or agglomeration (ability to cement the dust particles) are reviewed. The literature findings, recommendations, and limitations pertaining to dust suppression on unpaved roads are discussed at the end of the review.

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“…In a study by Fossat et al (), brain serotonin in Procambarus clarkii was positively correlated with decreased time spent in lighted regions of a dark/light plus maze, a result attributed to increased anxiety. In the crab Carcinus maenas , sheltering during daylight periods was reduced when animals were injected with serotonin (McPhee and Wilkens, ), and serotonin increased positive phototaxis in Gammarus pulex (Perrot‐Minnot et al , ) and Erythrobacter marinus (Ford and Willson, ). In the latter species, this effect was also seen in response to fluoxetine.…”

Section: The Impact Of Fluoxetine On Macroinvertebratesmentioning

confidence: 99%

The effects of environmental antidepressants on macroinvertebrates: a mini review

Shaliutina‐Kolešová

Shaliutina

Nian

2019

Water & Environment J

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Pharmaceuticals and personal care products constitute one of the most common groups of contaminants in surface waters, and little is known about their impact on aquatic wildlife. The antidepressant fluoxetine is among more prevalent categories of pharmaceuticals detected in the aquatic environment. Typical surface water concentrations are in a wide range that can lead to alterations in life of aquatic macroinvertebrates. Because the mode of fluoxetine action is thought to be by modulation of the neurotransmitter serotonin, macroinvertebrates that possess relevant transporters and receptors sensitive are potentially affected by this pharmaceutical. Available information of how this emerging contaminant may affect macroinvertebrate communities is limited. This review describes the influence of pharmaceuticals on aquatic fauna in general and reports the environmental concentrations of some widely used antidepressants. Additionally, we highlighted the effects of fluoxetine as an antidepressant of concern, because of its abundance and potential for toxicity to aquatic macroinvertebrates.

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Thermal analysis and calorimetry of pharmaceuticals

Cited by 15 publications

References 147 publications

Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam

Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam

Fugitive Dust Suppression in Unpaved Roads: State of the Art Research Review

The effects of environmental antidepressants on macroinvertebrates: a mini review

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