Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam

Emara, Laila H.; El-Ashmawy, Ahmed A.; Taha, Nesrin F.; El-Shaffei, Khaled A; Mahdey, El-Sayed M; El-Kholly, Heba K.

doi:10.7324/japs.2016.60205

Cited by 12 publications

(4 citation statements)

References 45 publications

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“…Emara et al 217 studied the effect of NCC and MCC carriers on the solubility of a poorly water-soluble drug, meloxicam (MX). They prepared solid dispersion via both cogrinding and physical mixing techniques, in the presence of lactose.…”

Section: Nanocellulose In Drug Delivery Systemsmentioning

confidence: 99%

Production of Nanocellulose and Its Applications in Drug Delivery: A Critical Review

Salimi

Sotudeh‐Gharebagh

Zarghami

et al. 2019

ACS Sustainable Chem. Eng.

196

116

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Nanocellulose, as a promising natural material, has recently received much attention because of its remarkable features including recyclability, biocompatibility, low risk of toxicity, and tunable surface properties. This review article first introduces three types of nanocellulose (nanocrystalline, nanofibrillar, and bacterial) and evaluates their production processes. In addition, contemporary research is discussed in the formulations of nanoparticles, tablets, hydrogels, and aerogels. As reported in the literature, the release time of nanocellulose-based systems varies from a few minutes to several days as they provide a controlled and sustained release. Thus, such systems have shown considerable potential for developing a novel generation of controlled drug delivery for different routes of administration (oral, transdermal, etc.). This review facilitates the selection of proper source and processing techniques for nanocellulose production while addressing opportunities and challenges ahead ending up with identifying sustainable ongoing research directions into its applications in drug delivery.

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Section: Nanocellulose In Drug Delivery Systemsmentioning

confidence: 99%

Production of Nanocellulose and Its Applications in Drug Delivery: A Critical Review

Salimi

Sotudeh‐Gharebagh

Zarghami

et al. 2019

ACS Sustainable Chem. Eng.

196

116

View full text Add to dashboard Cite

show abstract

“…Emara, El-Ashmawy, Taha, El-Shaffei, Mahdey, and El-kholly used as a novel tablet excipient for improving the solubility and dissolution of meloxicam (BCS class II). Results exhibited that CNC could be a promising tablet alternative to MCC …”

Section: Resultsmentioning

confidence: 99%

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Mishra

2024

ACS Omega

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Nanocrystalline cellulose (CNC) has emerged as a subject of researcher’s interest because of its diverse attributes encompassing biocompatibility, sustainability, a high aspect ratio, and an abundance of −OH groups suitable for modifications. Sugarcane bagasse microcrystalline cellulose (SCBMCC) was used as the raw material for the preparation of CNC due to its pure cellulose content, which is mildly compromised by the pectin, hemicellulose, lignin, and other lignocellulosic components. In the present work, CNC was extracted from SCBMCC and used as a disintegrant. The classic hydrolysis technique was used for the preparation of CNC. Hydrolytic conditions were optimized using the response surface methodology (RSM). The optimized batch of CNC was characterized using techniques such as field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Notably, CNC prepared under a hydrolysis time of 90 min exhibited the highest crystallinity of 69.9%. The average particle size and zeta potential were found to be 145 nm and −34.4 mV, respectively. Thermal analysis suggested that an intermediate hydrolysis time resulted in CNC with enhanced thermal stability, showcasing its potential for pharmaceutical applications. Diclofenac potassium was used as the model drug to evaluate the disintegrant properties of CNC as an excipient. Tablets were prepared using the direct compression method. SCBMCC and CNC were used as disintegrants and were compared with the commercial product. The disintegration times (DTs) attained for the tablets prepared using CNC and SCBMCC are 219 and 339.83 s, respectively. The dissolution study of CNC showed a dissolution efficacy (DE%) of 66 and a mean dissolution time (MDT) of 12. The research findings showed that tablets prepared using CNC as disintegrants exhibited the fastest disintegration compared to other formulations.

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“…The interactions were studied using molecular docking studies, and they found that these films are good carriers for other lipophilic drugs also [73]. Based on different studies carried out by Emara et al, it was found that nanocellulose-based systems were suitable supports for the delivery of poorly water-soluble drugs wherein the solubility increases with an increase in nanocellulose content [74]. Zheng et al [75] prepared CNF/alginate and MCC/alginate beads which were utilized for the release of metformin hydrochloride drug.…”

Section: Oral Drug Deliverymentioning

confidence: 99%

Nanocellulose as an Avenue for Drug Delivery Applications: A Mini-Review

Varghese

Cherian

Chirayil³

et al. 2023

J. Compos. Sci.

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A controlled and sustained release of an accurate dose of medications into a system can cure diseases associated with the human body. Different potential drug delivery vehicles, which are biocompatible and non-toxic, have been synthesized and developed for the controlled release of drugs targeting specific organs or areas. A delivery agent procured from sustainable sources with less or no side effects is more advantageous in terms of compatibility and toxicity. Among a few bioresources, one such material obtained is the nanocellulose-based drug delivery vehicle. They are ideal for the transport and release of drugs since they are biocompatible and possess good mechanical properties. A major characteristic feature of nanocellulose is that different surface modifications are possible due to the presence of a large number of hydroxyl groups, which can strengthen the interactions required with the therapeutic drug for delivery. Pharmaceutical drugs can strongly bind to the nanocellulose material through electrostatic interactions, and the release can occur in a sustained manner to the target within a few minutes to several days. In this mini-review, we have tried to summarize some of the most important works carried out in the field of nanocellulose-based drug delivery, different types of nanocellulose, its surface modification possibilities, and delivery of medications through three main routes, oral, transdermal, and topical, that have been reported to be effective.

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Nano-Crystalline Cellulose as a Novel Tablet Excipient for Improving Solubility and Dissolution of Meloxicam

Cited by 12 publications

References 45 publications

Production of Nanocellulose and Its Applications in Drug Delivery: A Critical Review

Production of Nanocellulose and Its Applications in Drug Delivery: A Critical Review

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Nanocellulose as an Avenue for Drug Delivery Applications: A Mini-Review

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