Therapeutic Role of Nanocurcumin Versus Monosodium Glutamate Toxicity

Mohamed, Mona A.; El-Nahrawy, Walaa; Zaher, Amr; Amer, Amany S.

doi:10.21608/eajbsz.2022.217532

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Given the important role of the morphology of the carotid arteries in the pathogenesis of brain perfusion disorders, the effect of the systematic use of monosodium glutamate on their structure has not been sufficiently studied. Of particular interest is the nature of morphological changes, their dynamics and the degree of irreversibility of possible damage, the reaction of tissues to the withdrawal of monosodium glutamate, as well as the possibility of correction [14].…”

Section: Introductionmentioning

confidence: 99%

Structural organization of the carotid sinus under the influence of monosodium glutamate in the experiment: analysis of changes in dynamics

Sodomora

2022

Rep. of Morph.

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Carotid artery pathology is one of the leading causes of cerebral stroke. Among the pathogenetic factors in the development of carotid artery damage, disorders of lipid metabolism, atherosclerosis, and metabolic syndrome occupy a prominent place. The alimentary factor is extremely important in this context. Monosodium glutamate is one of the most common food additives, which is often used uncontrollably and can cause changes in the structure and functions of organs and tissues. The purpose of the study: to analyze the dynamics of morphological changes in the carotid sinus area under the influence of monosodium glutamate when administered orally in an experiment. The area of the carotid sinus of 20 male laboratory white rats that received sodium glutamate orally at a dose of 10 mg/kg/day for 8 weeks was studied by morphological methods at the macro- and microstructural levels after 6 and 8 weeks of the experiment. The obtained data are compared with the results of a morphological study of the same area in 20 animals of the control group. Statistical processing of animal weight was performed using MS Excel 2007 software. Mean ± standard deviation was determined. After 6 weeks of the experiment, when evaluating the histological structure of the wall of the internal carotid artery in the area located directly above the bifurcation, when compared with the control group, multiplication and folding of the intima were found in the experimental group, presumably associated with the proliferation of endothelial cells under the influence of sodium glutamate, detachment of the endothelium and lysis of individual endotheliocytes, as well as uneven thickening of elastic media fibers and disruption of their structure. Attention was drawn to the accumulation of white fat perivasally and in the zone of the carotid glomus, as well as the disorganization of nerves and the expansion of vessels of the microcirculatory channel. After 8 weeks of the experiment, the negative dynamics of structural changes were noticeable: signs of increased inflammatory infiltration, deformation of the vessels of the microcirculatory bed with thickening of their walls and narrowing of the lumen, stasis, noticeable degranulation of cells of type I carotid glomus cells, the appearance of single labrocytes (mast cells) in the infiltrate. The amount of adipose tissue (white fat) in the area of the carotid sinus and the perivasal bifurcation of the carotid arteries, as well as in the immediate vicinity of the carotid glomus, also increased markedly, and a tendency towards thickening of adipose tissue was noted. Thus, monosodium glutamate with systematic oral use can cause a violation of the structural organization of the carotid sinus, the wall of the carotid arteries and the carotid glomus, and the severity of changes in dynamics increases. Further research is needed to clarify the nature of the structural changes in the carotid sinus under the conditions of withdrawal of monosodium glutamate, as well as to find possible ways of correction.

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Section: Introductionmentioning

confidence: 99%

Structural organization of the carotid sinus under the influence of monosodium glutamate in the experiment: analysis of changes in dynamics

Sodomora

2022

Rep. of Morph.

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Histopathological and immunohistochemical studies on the influence of orally administration monosodium glutamate, a food additive dependent on time in vivo

Hamad

2022

JoBAZ

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Background Monosodium glutamate is a widely used flavor enhancer/food additive in meat, fish, milk and cheese or vegetable origins. Our present study aimed to assess the effect of utilization monosodium glutamate on the cardiac, splenic, hepatic and renal organs in mice. Thirty animals were divided into three groups: control group; glutamate 10 treated groups and glutamate 15 treated group. The experimental period was two successive weeks. Results Oral administrations of monosodium glutamate for 10 days induced moderate histopathological changes in cardiac, splenic, hepatic and renal tissues and also resulted in significant increase of the nuclear factor-kB expression depend on time of administration as compared to the control group, while treatment with monosodium glutamate for 14 days resulted in severe histopathological changes as well as highly significant increase of the nuclear factor-kB expression as compared to the control group. Conclusions It could be concluded that oral administration of monosodium glutamate induced histopathological alterations, and cytotoxicity in cardiac, splenic, hepatic and renal tissues dependent on time.

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Therapeutic Role of Nanocurcumin Versus Monosodium Glutamate Toxicity

Cited by 2 publications

References 10 publications

Structural organization of the carotid sinus under the influence of monosodium glutamate in the experiment: analysis of changes in dynamics

Structural organization of the carotid sinus under the influence of monosodium glutamate in the experiment: analysis of changes in dynamics

Histopathological and immunohistochemical studies on the influence of orally administration monosodium glutamate, a food additive dependent on time in vivo

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