Histopathological and immunohistochemical studies on the influence of orally administration monosodium glutamate, a food additive dependent on time in vivo

Abstract

Background Monosodium glutamate is a widely used flavor enhancer/food additive in meat, fish, milk and cheese or vegetable origins. Our present study aimed to assess the effect of utilization monosodium glutamate on the cardiac, splenic, hepatic and renal organs in mice. Thirty animals were divided into three groups: control group; glutamate 10 treated groups and glutamate 15 treated group. The experimental period was two successive weeks. Results Oral administrations of monosodium glutamate for 10 days induced moderate histopathological changes in cardiac, splenic, hepatic and renal tissues and also resulted in significant increase of the nuclear factor-kB expression depend on time of administration as compared to the control group, while treatment with monosodium glutamate for 14 days resulted in severe histopathological changes as well as highly significant increase of the nuclear factor-kB expression as compared to the control group. Conclusions It could be concluded that oral administration of monosodium glutamate induced histopathological alterations, and cytotoxicity in cardiac, splenic, hepatic and renal tissues dependent on time.

Protective and/or Therapeutic Effects of Curcumin Nanoparticles on Monosodium Glutamate Induced Cardiotoxicity in Male Albino Rats

“…These results agreed with those of Hazzaa et al (2020), Hassan et al (2020), andAbo El Wafa et al (2021). The abnormalities might be attributed to MSG-induced oxidative damage (Hamad, 2022), as demonstrated in the present work by a rise in MDA and a reduction in TAC. The oxidative stress triggers the nuclear factor-κB signaling pathway, which can control numerous genes linked to inflammatory responses, including tumor necrosis factor-α and the caspases family, which causes cell death (Hamad, 2022).…”

“…The abnormalities might be attributed to MSG-induced oxidative damage (Hamad, 2022), as demonstrated in the present work by a rise in MDA and a reduction in TAC. The oxidative stress triggers the nuclear factor-κB signaling pathway, which can control numerous genes linked to inflammatory responses, including tumor necrosis factor-α and the caspases family, which causes cell death (Hamad, 2022). In addition, CUR-NPS administration alleviated the pathological changes caused by MSG, which is comparable with the findings of , who found that CUR-NPS reduced the histopathological abnormalities created in the hearts of copper sulfate-intoxicated rats.…”