The use of Nanoparticles (NPs) and nanostructured materials (NSMs) consider a new light in the progress of disease-modifying treatments for many pathological disorders. The present study is an attempt to investigate the curative effect of Nanocurcumin against long-term MSGadministration on rat liver. A total of 40 adult male Wistar albino rats were divided into the following groups: Control group (C) of 14 rats given saline; Nanocurcumin (Nano-Cur) control group of 14 rats inoculated orally with Nano-Cur (100mg/Kg b.wt/day)for 8 weeks; Monosodium group received MSG 10 mg/kg /b. w. for eight weeks; the therapeutic group was first given MSG alone for 4 weeks and was secondly administered Nano-Cur for 4 weeks. At the end of 8 weeks, animals were sacrificed by ether inhalation anesthesia where blood and liver tissues were collected to study biochemical parameters.MSG administration exerted significant elevation of cholesterol, TG, HDL, LDL, VLDL and MDA. Also showed an increase in liver enzymes. On the other hand, in the therapeutic group, Nano-Cur showed significant improvement in the previous parameters.
Purpose: To compare the effects of laser and/or L-carnitine (LC) on amiodarone (AM)-induced lung toxicity in adult male rats.
Methods: Lung toxicity was induced in 50 healthy male albino rats (150-180 g) by AM for 8 weeks. The rats were divided into 4 groups (7 per group): AM recovery, LC, laser, and laser + LC. After a 4-week exposure to laser and/or LC, key antioxidant enzymes, nitric oxide (NO), angiotensin II, cyclooxygenase-II (COX-II) and lipoxygenase (LOX) as well as oxidative stress and inflammation parameters were determined.
Results: Administration of LC and/or laser exposure led to significant increases in reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and angiotensin II; and significant decreases in nitric oxide (NO) level and glutathione-S-transferase (GST) activity in the AM
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.