Therapeutic Perspectives of Food Bioactive Peptides: A Mini Review

Abstract

Bioactive peptides are short chain of amino acids (usually 2-20) that are linked by amide bond in a specific sequence which have some biological effects in animals or humans. These can be of diverse origin like plant, animal, fish, microbe, marine organism or even synthetic. They are successfully used in the management of many diseases. In recent years increased attention has been raised for its effects and mechanism of action in various disease conditions like cancer, immunity, cardiovascular disease, hypertension, inflammation, diabetes, microbial infections etc. Bioactive peptides are more bioavailable and less allergenic when compared to total proteins. Food derived bioactive peptides have health benefits and its demand has increased tremendously over the past decade. This review gives a view on last two years research on potential bioactive peptides derived from food which have significant therapeutic effects.

Recent research progress of biologically active peptides

“…It is mainly formed by 2–20 amino acid residues, which can promote human health 2 . Bioactive peptides come from plants, animals, fish, microorganisms, marine organisms, and even synthetic products 3 …”

“…Every year, millions of people around the world die from lifestyles and related complications, such as cancer, obesity, high cholesterol, cardiovascular disease, high blood pressure, inflammation, diabetes, and so forth. People are currently exploring lifestyle‐related diseases and their complications 3,29 . Bioactive peptides have important effects on the nervous, immune, and gastrointestinal systems.…”

“…2 Bioactive peptides come from plants, animals, fish, microorganisms, marine organisms, and even synthetic products. 3 The physiological functions of BAPs are diverse, such as hormone effects, 4 immune regulation, 5 antithrombosis, 6 antihypertension, 7 cholesterol-lowering, 8 antibacterial, 9 antiviral, 10 and anticancer effects. 11 These functions are unique physiological functions that the original protein or constituent amino acids do not possess, and the constituent amino acids of many active peptides are not…”

“…People are currently exploring lifestyle-related diseases and their complications. 3,29 Bioactive peptides have important effects on the nervous, immune, and gastrointestinal systems. Bioactive peptides have the advantages of high biological activity, low toxicity, and easy metabolism in the human body.…”

Royal Jelly Proteins and Their Derived Peptides: Preparation, Properties, and Biological Activities

“…Recently, the predominant bioactive peptides in royal jelly were obtained naturally or proteolytically released; − however, the application of microbial fermentation has not been explored. The natural peptides in royal jelly, royalisin and jelleines, have antibacterial effects. , Peptides produced using enzymatic hydrolysis from royal jelly exert antihypertensive, antioxidative, anti-aging, and antibacterial activities. − These beneficial effects will expand the applications of royal jelly as a potential therapeutic agent and functional food ingredient. − …”