Therapeutic microRNAs targeting the NF-kappa B signaling circuits of cancers

Tong, Lingying; Yuan, Ye; Wu, Shiyong

doi:10.1016/j.addr.2014.09.004

Cited by 40 publications

(31 citation statements)

References 185 publications

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“…4 Recent studies have reported on the use of miRNA as a new prognostic and diagnostic biomarker for malignancies. 10 MiR-181a is another type of microRNA, which belongs to the miR-181 family; it has two different subtypes: miR-181a1 on chromosome 1 and miR-181a2 on chromosome 9, its expression levels were correlated to lung and breast cancer 11 and acts similarly to miR-155 as an oncogene but its main role as a tumor suppressor has been proven many times. 6 It has been shown to act as an oncogene in triple-negative breast cancer by targeting the von Hippel-Lindau (VHL) tumor suppressor gene 7 and is also involved in the regulation of several other cancer-related pathways.…”

Section: Introductionmentioning

confidence: 99%

miRNA‐155 and miRNA‐181a as prognostic biomarkers for pediatric acute lymphoblastic leukemia

El‐Khazragy

Noshi

Abdel-Malak

et al. 2018

J of Cellular Biochemistry

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Mortality rates of acute lymphoblastic leukemia (ALL) have improved over the past 20 years; however, a significant portion of deaths stems from the lack of prognostic biomarkers, which can direct therapy and overcome drug resistance. microRNA‐155a (miRNA‐155a) and miRNA‐181a are two single‐stranded miRNAs involved in the pathogenesis of many types of leukemia and lymphoma and is linked to drug resistance. We investigated their expression levels in 55 patients, 45 diagnosed with ALL and 10 as a control group. We found that miRNA‐155a and miRNA‐181a were significantly upregulated in the ALL group with both being linked to high levels of minimal residual disease and poor prognosis. miRNA‐155a cutoff value was significant in discriminating between high‐ and low‐risk ALL patients as well as between ALL patients and healthy controls, miRNA‐181a cutoff value, however, was not significant. Both markers levels were significantly downregulated after therapy. We conclude that miR‐155 is correlated with poor prognosis in ALL, whereas we couldn’t link miRNA‐181a to the prognosis in ALL. Moreover, the marked decrease in their expression after therapy could reflect their impact on disease outcome.

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Section: Introductionmentioning

confidence: 99%

miRNA‐155 and miRNA‐181a as prognostic biomarkers for pediatric acute lymphoblastic leukemia

El‐Khazragy

Noshi

Abdel-Malak

et al. 2018

J of Cellular Biochemistry

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“…Abnomal activation of NF-κB has been found in many types of cancer, including esophageal carcinoma (30)(31)(32); however, the activation mechanisms have not been elucidated. Accumulating publications have shown that miRNAs such as miR-146, miR-155, miR-21, and miR-301a have pathological relevance to NF-κB signaling (33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma

Yang

Zang

Xing

et al. 2015

International Journal of Oncology

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Newly discovered intrinsic regulators, the miRNAs regulate gene expression by binding to the 3'-untranslated regions of the genome. Accumulating studies have indicated that miRNAs are aberrantly expressed in various human cancers. We found that miRNA-1207-5p (miR‑1207-5p) was markedly downregulated in esophageal carcinoma (EC) tissues, and was correlated with EC differentiation, pathological stage and lymph node metastasis. Rates of apoptosis were increased and cell invasion ability was decreased in EC9706 and EC-1 cells transfected with a miR‑1207-5p mimic. Stomatin-like protein 2 (STOML-2) was predicted to be a potential target of miR‑1207-5p by bioinformatics analysis and this was confirmed by luciferase assay and western blotting. Our study showed that STOML-2 was negatively regulated by miR‑1207-5p. Furthermore, overexpression of STOML-2 abolished the miR‑1207-5p anti-invasion function. Based on these results, we proposed that miR‑1207-5p might act as a potential therapeutic target in the treatment of EC.

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“…Increasing research has focused on using miRNAs as new therapeutic agents in tumor therapy. Inhibiting NF-κB activation by miR-31 in breast cancer promoted cell death and increased cell sensitivity to ionizing radiation (38). Zhang et al (39) found that miR-451 can increase radiosensitivity of NPC cells by targeting RAB14.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-4649-3p inhibits cell proliferation by targeting protein tyrosine phosphatase SHP-1 in nasopharyngeal carcinoma cells

Pan

Peng

et al. 2015

International Journal of Molecular Medicine

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The present study aimed to investigate the influence of microRNA-4649-3p on nasopharyngeal carcinoma (NPC) cell proliferation and how it regulated SHP-1 expression. The online software TargetScan was used to predict the microRNAs targeting SHP-1 and identified that miR-4649-3p was one of the possible miRNAs targeting SHP-1. Subsequently, quantitative polymerase chain reaction (PCR) was used to detect the expression level of miR-4649-3p and SHP-1 mRNA in different NPC cell lines. The miR-4649-3p mimics and inhibitors were transfected into NPC cells and cell proliferation was examined by the MTT assay. The SHP-1 expression level was determined by PCR and western blot analysis. Lentivirus containing the SHP-1 gene and miR-4649-3p mimics was co-transfected into the NPC cells and cell proliferation was detected by the MTT assay. The expression level of miR-4649-3p and SHP-1 mRNA was negatively correlated in the NPC cell lines. miR-4649-3p mimics suppressed NPC cell proliferation whereas miR-4649-3p inhibitors promoted NPC cell proliferation. The SHP-1 expression level was suppressed when transfected with miR-4649-3p mimics in NPC cells. The miR-4649-3p inhibitors increased SHP-1 expression. The luciferase reporter assay showed that miR-4649-3p directly targeted SHP-1 by binding to the 3'-untranslated region of SHP-1 mRNA. Overexpression of SHP-1 inversed the inhibited effect of miR-4649-3p mimics on cell proliferation. In conclusion, miR-4649-3p inhibits cell proliferation by targeting SHP-1 in NPC cells.

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Therapeutic microRNAs targeting the NF-kappa B signaling circuits of cancers

Cited by 40 publications

References 185 publications

miRNA‐155 and miRNA‐181a as prognostic biomarkers for pediatric acute lymphoblastic leukemia

miRNA‐155 and miRNA‐181a as prognostic biomarkers for pediatric acute lymphoblastic leukemia

miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma

MicroRNA-4649-3p inhibits cell proliferation by targeting protein tyrosine phosphatase SHP-1 in nasopharyngeal carcinoma cells

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