miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma

Yang, Xuan; Zang, Wenqiao; Xing, Xuan; Wang, Zhongquan; Liu, Zhicai; Wang, Jinwu; Cui, Jing

doi:10.3892/ijo.2015.2900

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…reported that LncRNA BC032469 could competitively bind to miR‐1207‐5p to regulate hTERT expression and promote tumor suppression. Yang et al . showed that miR‐1207‐5p decreased the target gene STOML‐2 in esophageal cancer, which was related to the differentiation status and pathological stage of the tumor, as well as to the presence/absence of lymph node metastasis.…”

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confidence: 99%

“…L€ u et al (20) reported that LncRNA BC032469 could competitively bind to miR-1207-5p to regulate hTERT expression and promote tumor suppression. Yang et al (21) showed that miR-1207-5p decreased the target gene STOML-2 in esophageal cancer, which was related to the differentiation status and pathological stage of the tumor, as well as to the presence/absence of lymph node metastasis. Wu et al (22) reported that increased expression of miR-1207-5p in ovarian cancer promoted the transformation of tumor cells to stem cells by activating the Wnt/b-catenin pathway.…”

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confidence: 99%

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PVT1‐derived miR‐1207‐5p promotes breast cancer cell growth by targeting STAT6

et al. 2017

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Accumulating evidence indicates that ectopic expression of non‐coding RNAs are responsible for breast cancer progression. Increased non‐coding RNA PVT1, the host gene of microRNA‐1207‐5p (miR‐1207‐5p), has been associated with breast cancer proliferation. However, how PVT1 functions in breast cancer is still not clear. In this study, we show a PVT1‐derived microRNA, miR‐1207‐5p, that promotes the proliferation of breast cancer cells by directly regulating STAT6. We first confirm the positive correlated expression pattern between PVT1 and miR‐1207‐5p by observing consistent induced expression by estrogen, and overexpression in breast cancer cell lines and breast cancer patient specimens. Moreover, silence of PVT1 also decreased miR‐1207‐5p expression. Furthermore, increased miR‐1207‐5p expression promoted, while decreased miR‐1207‐5p expression suppressed, cell proliferation, colony formation, and cell cycle progression in breast cancer cell lines. Mechanistically, a novel target of miR‐1207‐5p,STAT6, was identified by a luciferase reporter assay. Overexpression of miR‐1207‐5p decreased the levels of STAT6, which activated CDKN1A and CDKN1B to regulate the cell cycle. We also confirmed the reverse correlation of miR‐1207‐5p and STAT6 expression levels in breast cancer samples. Therefore, our findings reveal that PVT1‐derived miR‐1207‐5p promotes the proliferation of breast cancer cells by targeting STAT6, which in turn controls CDKN1A and CDKN1B expression. These findings suggest miR‐1207‐5p might be a potential target for breast cancer therapy.

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PVT1‐derived miR‐1207‐5p promotes breast cancer cell growth by targeting STAT6

et al. 2017

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“… 21 miR-1207-5p also influences tumor progression in esophageal carcinoma. 9 Therefore, based on the studies mentioned, we propose that miR-1207-5p may be a potential target in PGBC therapy, as well.…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRNAs) are a class of noncoding RNAs that are 18–25 nucleotides in length and play important roles in various cellular processes, including proliferation, differentiation, metabolism, and apoptosis. 8 , 9 Previous studies have demonstrated that miRNAs expression varies in human cancers, such as esophageal cancer and colorectal cancer, and that these molecules function as tumor suppressors or oncogenes. 10 , 11 Among the miRNA families, miR-1207-5p is highly expressed in gastrointestinal cancers.…”

Section: Introductionmentioning

confidence: 99%

“… 12 , 13 In esophageal carcinoma, miR-1207-5p is associated with cancer progression by targeting STOML-2. 9 However, the role of miR-1207-5p in PGBC, especially its effect on therapeutic chemosensitivity, has not been well documented. Given that molecular markers associated with PGBC chemosensitivity aid in producing better outcomes, 14 , 15 miR-1207-5p represents a novel target and may yield insights into PGBC therapy.…”

Section: Introductionmentioning

confidence: 99%

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The effects of miR-1207-5p expression in peripheral blood on cisplatin-based chemosensitivity of primary gallbladder carcinoma

Shen

Liu

et al. 2016

OTT

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ObjectiveThe aim of this study was to investigate the association between miR-1207-5p expression in peripheral blood and the chemosensitivity of primary gallbladder carcinoma (PGBC).MethodsA total of 85 patients with PGBC undergoing preoperative chemotherapy were divided into effective (n=18) and ineffective (n=67) groups. Another 70 healthy individuals were selected as the control group. An miR-1207-5p mimic (mimic group), an inhibitor (inhibitor group), and a negative control (NC group) sequence were transfected into human gallbladder carcinoma GBC-SD cells. Real-time quantitative polymerase chain reaction was used to determine miR-1207-5p expression. After 48 hours of cisplatin treatment, CCK-8 method was used to detect cell proliferation and flow cytometry were performed to examine cell apoptosis.ResultsmiR-1207-5p expression in peripheral blood was significantly associated with tumor node metastasis staging of PGBC (P<0.05). Before chemotherapy, miR-1207-5p expression in patients was higher than in healthy individuals (P<0.05). After chemotherapy, the effective group had lower miR-1207-5p expression than the ineffective group (P<0.05). The rates of positive expression of Ki67 protein in the effective group were significantly lower than those in the ineffective group (P<0.05). Receiver operating characteristic curves showed that the area under curve, sensitivity, and specificity of miR-1207-5p used to diagnose PGBC were 0.898, 77.6%, and 97.1% at a cutoff of 1.470, respectively. After 48 hours of cisplatin treatment, compared with the NC group and nontransfected (non-T) group, the mimic group had decreased rates of cell inhibition and apoptosis, but the inhibitor group had increased rates (all P<0.05). The expression levels of caspase3 protein were increased in the mimic group and decreased in the inhibitor group. Cell survival rates in the mimic group at different time points after cisplatin treatment were significantly higher than the corresponding rates in the NC and non-T groups, whereas the cell survival rates in the inhibitor group were significantly lower than the rates in the NC and non-T groups (all P<0.05). The concentration and action time of cisplatin were negatively associated with the cell survival rate in each group (all P<0.05).ConclusionCisplatin-based chemosensitivity of PGBC increased as expression of miR-1207-5p in peripheral blood declined. Thus, miR-1207-5p appears to be a promising and novel chemosensitizer for the treatment of PGBC.

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Upregulation of LINC00319 indicates a poor prognosis and promotes cell proliferation and invasion in cutaneous squamous cell carcinoma

Liao

Duan

et al. 2018

J of Cellular Biochemistry

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Cutaneous squamous cell carcinoma (CSCC), an epidermal keratinocyte-derived skin tumor, is one of the most leading causes of cancer-associated morbidity and mortality worldwide. Long noncoding RNAs have emerged as key regulators of tumor development and progression. Recent studies have identified LINC00319, a long intergenic noncoding RNA, as an oncogene in lung cancer. However, the biological role of LINC00319 in CSCC remains largely unknown. The current study aimed to explore the role of LINC00319 in CSCC and uncover the molecular mechanisms. In current study, we found that LINC00319 was significantly upregulated in both CSCC tissues and cell lines. Besides, the χ test showed that increased expression of LINC00319 was associated with larger tumor size, advanced TNM stage, and lymphovascular invasion. Gain-of-function and loss-of-function approaches were applied to investigate the effects of LINC00319 on CSCC cells. Functional studies demonstrated that LINC00319 promoted CSCC cell proliferation, accelerated cell cycle progression, facilitated cell migration and invasion, and inhibited cell apoptosis. Mechanistic studies revealed that LINC00319 exerts its oncogenic functions in CSCC via miR-1207-5p-mediated regulation of cyclin-dependent kinase 3. Taken together, upregulation of LINC00319 implies a potential link with poor prognosis and reflects CSCC progression. Collectively, this study may provide some evidence for LINC00319 as a candidate target in CSCC treatment.

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miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma

Cited by 10 publications

References 39 publications

PVT1‐derived miR‐1207‐5p promotes breast cancer cell growth by targeting STAT6

PVT1‐derived miR‐1207‐5p promotes breast cancer cell growth by targeting STAT6

The effects of miR-1207-5p expression in peripheral blood on cisplatin-based chemosensitivity of primary gallbladder carcinoma

Upregulation of LINC00319 indicates a poor prognosis and promotes cell proliferation and invasion in cutaneous squamous cell carcinoma

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