Therapeutic Evaluation of Chemically Synthesized Copper Nanoparticles to Promote Full-Thickness Excisional Wound Healing

Abstract

Objective: The purpose of this research was, synthesis of copper nanoparticles using environment friendly cementation method and evaluate their wound healing property on full-thickness excisional wound.
 Methods: Present study reports the synthesis of CNPs by single-step cementation method. Evaluation of CNPs was endorsed by morphological and chemical properties. Furthermore, CNPs was evaluated for its antibacterial potential and invitro hemocompatibility. Additionally, pharmacological evaluation of CNPs was assessed against excisional wound.
 Results: Characterization of final product indicate, particle size of CNPs were ranging from 100-150 nm. CNPs showed significant antibacterial activity (A= 2.1±0.1 mm, B =2.1±0.1 mm, C = 1.9±0.2 mm, at 10µg/ml), along with superior hemocompatibility (RBC cell survival 97±1 %). Further CNPs formulation shows increased level of anti-inflammatory cytokinin’s (IL-10, 42.7%) as compared to standard (STD), vehicle control, and normal control groups, attributed to accelerated wound healing (p<0.05 vs STD).
 Conclusion: The consequences the present investigation endorse the accelerated wound healing potential of CNPs with its anti-inflammatory potential.

Preparation and Evaluation of Copper Nanoparticles Loaded Hydrogel for Burns

“…Copper nanoparticles were prepared in the previous publication [8], HPMC, PVP K30, and polyethylene glycol 400 (PEG-400) were purchased from a central drug house, New Delhi, India. All other chemicals were of analytical grade.…”

“…PEG 400 was added and mixed. Finally, the copper nanoparticles were dispersed in the remaining distilled water and added to the gel mixture to make up the volume to 50 ml [8].…”

Formulation and QBD Based Optimization of Methotrexate-Loaded Solid Lipid Nanoparticles for an Effective Anti-Cancer Treatment

“…The freshly prepared MTX SLNs (diluted with water (1:10)) were placed on a carbon-laminated copper lattice. Later, each sample was air-dried before observing under TEM [22].…”

Fluconazole Nanogel: Fabrication and in Vitro Evaluation for Topical Application

“…From the results obtained it can be concluded that Formulation A6 (particle size of 149.50±0.5 nm) shows better % EE and has optimum percent drug release. The smaller size of nanoparticles will help to increase the permeation of the drug through the biological membrane at the target site indicating its efficiency to deliver the drug through a topical route [16].…”