Arthritis is a musculoskeletal system disorder which involves destabilization of normal mechanisms. Due to changing habits of living life, the number of arthritic people will increase rapidly. Currently, the existing anti-rheumatic drugs mostly show side effects like acne, blurred vision, high blood pressure and more effective to reduce pain and improve disease conditions but still, they do not treat the disease completely. Literature available indicates that most of the people seek complementary alternative treatments (CAM). Ginger (Zingiber officinale) has empirically explored its use as an anti-inflammatory agent. Amongst others, the Topical route of drug delivery has built up popularity because it avoids first-pass effects, metabolic breakdown associated with oral administration and gastrointestinal irritation. Also, they are less greasy and can be easily washed off from the skin surface. The current study aimed to formulate antiarthritic gel containing ginger extract and to evaluate its drug release activity. The topical ginger gels were prepared using Carbopol 934 as a gelling agent with varying concentrations, i.e., 0.5 %, 1 %, and 1.5 % w/w. The gel was assayed to determine percent purity and cumulative drug release. Results indicated that the 1.5 % w/w concentration of carbopol in ginger gel exhibited an adequate drug release. In conclusion, an antiarthritic gel containing 1.5 % w/w of carbopol had a good consistency, acceptable spreadability, and showed a good drug release profile. The topical prepared herbal ginger gel is a simple, easily formulated, convenient and economical alternative that needs to be weighed in the treatment of RA.
Aim: To evaluate the efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in vitro and in vivo in the treatment of breast cancer. Materials & methods: MTX-NPs were tested for cellular uptake, cell viability, cell cycle, cellular wound migration and changes in tumor volume using characterized NPs. Results: The solid lipid NPs (SLNPs) showed strong cellular uptake, increased apoptosis, controlled cytotoxicity at lower IC50 of methotrexate and a sizable reduction in tumor burden. Conclusion: MTX-NP oral formulation can be a promising candidate in breast cancer treatment with improved cellular uptake and in vivo efficacy.
Objective: In the current study, the Quality by Design method was utilized for the formulation of solid lipid nanoparticles of Methotrexate (MTX SLNs).
Methods: MTX SLNs formulated by melt emulsification method were studied for the effect of independent variables viz. concentration of lipid and surfactants on quality attributes viz. particle size, polydispersity index, and entrapment efficiency of SLNs using 32 factorial design.
Results: The optimal formulation was spherical, had a particle size of 147.6±4.1 nm (z-average), a polydispersity index of 0.296±0.058, a zeta potential of −19±0.98 mV, encapsulation efficiency of 98.7±1.55%, and a cumulative drug release of 95.59±0.918% in 5 h.
Conclusion: The in vitro and in vivo studies revealed that SLNs provide a promising oral delivery system to improve the bioavailability of MTX.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.